Abstract
The objective herein is to provide refraction data, myopia progression rate, prevalence, and 1st and 2nd generation correlations, relevant to whether myopia is random or inherited. First- and second-generation ocular refraction data are assembled from N = 34 families, average of 2.8 children per family. From this group, data are available from N = 165 subjects. Inter-generation regressions are performed on all the data sets, including correlation coefficient r, and myopia prevalence [%]. Prevalence of myopia is [M] = 38.5 %. Prevalence of high myopes with |R| >6 D is [M−] = 20.5 %. Average refraction is <R> = −1.84 D ± 3.22 (N = 165). For the high myopes, |R| >6 D, prevalence for the parents is [M−] = 25 %, for the 2nd generation [M−] = 16.5 %. Average myopia level for the high myopes, both generations, is <S> = −7.52 D ± 1.31 D (N = 33). Regression parameters are calculated for all the data sets, yielding correlation coefficients in the range r = 0.48–0.72 for some groups of myopes and high myopes, fathers to daughters, and mothers to sons. Also of interest, some categories show essentially no correlation, −0.20 < r < 0.20, indicating that the refractive errors occur randomly. Time series results show myopia diopter rates = −0.50 D/year.
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Appendix I: Regression statistics N = 165 subjects
Appendix I: Regression statistics N = 165 subjects
Inter-generation refraction correlations:
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(1)
Father Rf to sons Rs:
Rs = 0.20 * Rf −1.39 D. [σ = ± 2.97 D, r = 0.212, N = 49]
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(2)
Father Rf to daughters Rd:
Rd = 0.23 * Rf −1.29 D. [σ = ± 3.10 D, r = 0.267, N = 48]
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(3)
Mother Rm to sons Rs:
Rs = −0.08 * Rm −1.92 D [σ = +/−3.02 D, r = −0.080, N = 49]
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(4)
Mother Rm to daughters Rd:
Rd = 0.35 * Rm −1.45 D. [σ = ±2.94 D, r = 0.356, N = 48]
Figure 6.
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Greene, P.R., Medina, A. Refraction data survey: 2nd generation correlation of myopia. Int Ophthalmol 36, 609–614 (2016). https://doi.org/10.1007/s10792-016-0172-0
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DOI: https://doi.org/10.1007/s10792-016-0172-0