Skip to main content
SpringerLink
Log in

Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases

  • Review
  • Published:
Inflammopharmacology Aims and scope Submit manuscript

Abstract

Inflammatory infiltration has been implicated in the pathogenesis of cardiovascular diseases (CVDs). The NLRP3 inflammasome is involved in the development of several types of CVDs, including myocardial infarction, myocardial ischemia–reperfusion damage, heart failure, atrial fibrillation, and hypertension. Inhibiting the activity of NLRP3 inflammasome can inhibit the progress of CVDs. However, there is no NLRP3 inflammasome inhibitor in clinic, and it is very important to find a safe and effective NLRP3 inhibitor. Phenols and terpenoids are naturally natural products that have many anti-inflammatory effects in CVDs by modulating the NLRP3 inflammatory pathway. Thus, 20 natural products from phenols and terpenoids for the treatment of cardiovascular disease based on the inhibition of NLRP3 inflammasome were summarized and screened. Docking results showed salvianolic acid B and ellagic acid in phenols, and oridonin and triptolide in terpenoids had a better binding activity with NLRP3, which can provide theoretical support for finding novel NLRP3 inflammasome inhibitors or lead compounds in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

The data used to support the findings of this study are available from the corresponding author upon request.

References

  • Akbari G (2020) Molecular mechanisms underlying gallic acid effects against cardiovascular diseases: an update review. Avic J Phytomed 10:11–23

    CAS  Google Scholar 

  • Aktaş I, Özmen Ö, Tutun H, Yalçın A, Türk A (2020) Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats. Biotech Histochem 95:121–128

    PubMed  Google Scholar 

  • Alyaseer A, de Lima M, Braga TT (2020) The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis. Front Immunol 11:883

    CAS  PubMed  PubMed Central  Google Scholar 

  • Amiri S, Dastghaib S, Ahmadi M, Mehrbod P, Khadem F, Behrouj H, Ghavami S (2020) Betulin and its derivatives as novel compounds with different pharmacological effects. Biotechnol Adv 38:107409

    CAS  PubMed  Google Scholar 

  • Bai L, Li J, Li H, Song J, Zhou Y, Lu R, Zhou J (2019a) Renoprotective effects of artemisinin and hydroxychloroquine combination therapy on IgA nephropathy via suppressing NF-κB signaling and NLRP3 inflammasome activation by exosomes in rats. Biochem Pharmacol 169:113619

    CAS  PubMed  Google Scholar 

  • Bai XL, Deng XL, Wu GJ, Li WJ, Jin S (2019b) Rhodiola and salidroside in the treatment of metabolic disorders. Mini Rev Med Chem 19:1611–1626

    CAS  PubMed  Google Scholar 

  • Baradaran Rahimi V, Ghadiri M, Ramezani M, Askari VR (2020) Antiinflammatory and anti-cancer activities of pomegranate and its constituent, ellagic acid: evidence from cellular, animal, and clinical studies. Phytother Res 34:685–720

    PubMed  Google Scholar 

  • Ben-Othman S, Kaldmäe H, Rätsep R, Bleive U, Aluvee A, Rinken T (2021) Optimization of ultrasound-assisted extraction of phloretin and other phenolic compounds from apple tree leaves (malus domestica borkh) and comparison of different cultivars from estonia. Antioxidants 10:189

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen L, Lan Z (2017) Polydatin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation by inhibiting NF-κB/NLRP3 inflammasome activation via the AMPK/SIRT1 pathway. Food Funct 8:1785–1792

    CAS  PubMed  Google Scholar 

  • Chen L, Liu P, Feng X, Ma C (2017) Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo. J Cell Mol Med 21:3178–3189

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cui D, Liu S, Tang M, Lu Y, Zhao M, Mao R, Liu J (2020) Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption. Phytomedicine 66:153111

    CAS  PubMed  Google Scholar 

  • Dai W, Wang X, Teng H, Li C, Wang B, Wang J (2019) Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats. Int Immunopharmacol 66:215–223

    CAS  PubMed  Google Scholar 

  • Degot P, Huber V, Hofmann E, Hahn M, Touraud D, Kunz W (2021) Solubilization and extraction of curcumin from Curcuma Longa using green, sustainable, and food-approved surfactant-free microemulsions. Food Chem 336:127660

    CAS  PubMed  Google Scholar 

  • Ding N, Wei B, Fu X, Wang C, Wu Y (2020) Natural products that target the NLRP3 inflammasome to treat fibrosis. Front Pharmacol 11:591393

    CAS  PubMed  PubMed Central  Google Scholar 

  • Doss HM, Dey C, Sudandiradoss C, Rasool MK (2016) Targeting inflammatory mediators with ferulic acid, a dietary polyphenol, for the suppression of monosodium urate crystal-induced inflammation in rats. Life Sci 148:201–210

    CAS  PubMed  Google Scholar 

  • Feng H, Mou SQ, Li WJ, Zhang N, Zhou ZY, Ding W, Liao HH (2020) Resveratrol inhibits ischemia-induced myocardial senescence signals and NLRP3 inflammasome activation. Oxid Med Cell Longev 2020:2647807

    PubMed  PubMed Central  Google Scholar 

  • Fu C, Zhang X, Lu Y, Wang F, Xu Z, Liu S, Liu X (2020a) Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation. Int Immunopharmacol 84:106547

    CAS  PubMed  Google Scholar 

  • Fu Y, Yan M, Xie C, Hu J, Zeng X, Hu Q (2020b) Polydatin relieves paraquat-induced human MRC-5 fibroblast injury through inhibiting the activation of the NLRP3 inflammasome. Ann Transl Med 8:765

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fu Y, Yuan PP, Cao YG, Ke YY, Zhang Q, Hou Y, Zheng XK (2020c) Geniposide in gardenia jasminoides var. Radicans makino modulates blood pressure via inhibiting WNK pathway mediated by the estrogen receptors. J Pharm Pharmacol 72:1956–1969

    CAS  PubMed  Google Scholar 

  • Gong Z, Zhao S, Zhou J, Yan J, Wang L, Du X, Wu J (2018) Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production. Mol Immunol 104:11–19

    CAS  PubMed  Google Scholar 

  • Han J, Shi G, Li W, Xie Y, Li F, Jiang D (2021) Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study. J Nat Med 75:37–47

    CAS  PubMed  Google Scholar 

  • He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Zhou R (2018) Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun 9:2550

    PubMed  PubMed Central  Google Scholar 

  • He Y, Lu X, Chen T, Yang Y, Zheng J, Chen C, Lei W (2021) Resveratrol protects against myocardial ischemic injury via the inhibition of NF-κB-dependent inflammation and the enhancement of antioxidant defenses. Int J Mol Med 47:29

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hou CY, Tain YL, Yu HR, Huang LT (2019) The effects of resveratrol in the treatment of metabolic syndrome. Int J Mol Sci 20:535

    CAS  PubMed Central  Google Scholar 

  • Hu R, Wang MQ, Ni SH, Wang M, Liu LY, You HY, Wei LB (2020a) Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK/NF-κB/NLRP3 signaling pathway in AGEs-induced HUVECs. Eur J Pharmacol 867:172797

    CAS  PubMed  Google Scholar 

  • Hu X, Ding L, Cao S, Cheng L, Wang K, Guang C, Qiu F (2020b) Pharmacokinetics, tissue distribution and excretion of paeonol and its major metabolites in rats provide a further insight into paeonol effectiveness. Front Pharmacol 11:190

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hu Y, Wang X, Li Q, Pan Y, Xu L (2020c) Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome. Mol Med Rep 22:5199–5208

    CAS  PubMed  PubMed Central  Google Scholar 

  • Huang W, Huang M, Ouyang H, Peng J, Liang J (2018) Oridonin inhibits vascular inflammation by blocking NF-κB and MAPK activation. Eur J Pharmacol 826:133–139

    CAS  PubMed  Google Scholar 

  • Huang JH, Lan CC, Hsu YT, Tsai CL, Tzeng IS, Wang P, Hsieh PC (2020) Oridonin attenuates lipopolysaccharide-induced ROS accumulation and inflammation in HK-2 cells. Evid-Based Complement Altern Med 2020:9724520

    Google Scholar 

  • Jiang L, Wang J, Ju J, Dai J (2020a) Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process. Eur J Pharmacol 883:173352

    CAS  PubMed  Google Scholar 

  • Jiang X, Chen S, Zhang Q, Yi C, He J, Ye X, Lu W (2020b) Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis. Phytomedicine 67:153160

    CAS  PubMed  Google Scholar 

  • Jin P, Li LH, Shi Y, Hu NB (2021) Salidroside inhibits apoptosis and autophagy of cardiomyocyte by regulation of circular RNA hsa_circ_0000064 in cardiac ischemia-reperfusion injury. Gene 767:145075

    CAS  PubMed  Google Scholar 

  • Kannan MM, Quine SD (2013) Ellagic acid inhibits cardiac arrhythmias, hypertrophy and hyperlipidaemia during myocardial infarction in rats. Metabolism 62:52–61

    CAS  PubMed  Google Scholar 

  • Kiasalari Z, Afshin-Majd S, Baluchnejadmojarad T, Azadi-Ahmadabadi E, Esmaeil-Jamaat E, Fahanik-Babaei J, Roghani M (2021) Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis. J Chem Neuroanat 111:101891

    CAS  PubMed  Google Scholar 

  • Kim SK, Choe JY, Park KY (2019) Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7. Biochem Biophys Res Commun 517:338–345

    CAS  PubMed  Google Scholar 

  • Kim K, Nam KH, Yi SA, Park JW, Han JW, Lee J (2020) Ginsenoside Rg3 induces browning of 3T3-L1 adipocytes by activating AMPK signaling. Nutrients 12:427

    CAS  PubMed Central  Google Scholar 

  • Kocaadam B, Şanlier N (2017) Curcumin, an active component of turmeric (curcuma longa), and its effects on health. Crit Rev Food Sci Nutr 57:2889–2895

    CAS  PubMed  Google Scholar 

  • Kong F, Ye B, Cao J, Cai X, Lin L, Huang S, Huang Z (2016) Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB and P2X7R signaling in PMA-induced macrophages. Front Pharmacol 7:369

    PubMed  PubMed Central  Google Scholar 

  • Kosuru R, Kandula V, Rai U, Prakash S, Xia Z, Singh S (2018) Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats. Cardio Drugs Ther 32:147–163

    CAS  Google Scholar 

  • Li D, Han T, Liao J, Hu X, Xu S, Tian K, Xu J (2016) Oridonin, a promising ent-Kaurane diterpenoid lead compound. Int J Mol Sci 17:1395

    PubMed Central  Google Scholar 

  • Li R, Lu K, Wang Y, Chen M, Zhang F, Shen H, Zhang Z (2017a) Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression. Biochem Biophys Res Commun 485:69–75

    CAS  PubMed  Google Scholar 

  • Li X, Wu N, Zou L, Jia D (2017b) Protective effect of celastrol on myocardial ischemia-reperfusion injury. Anatol J Cardiol 18:384–390

    CAS  PubMed  PubMed Central  Google Scholar 

  • Li C, Chen L, Song M, Fang Z, Zhang L, Coffie JW, Wang H (2020a) Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy. Arch Pharmacal Res 43:863–874

    CAS  Google Scholar 

  • Li F, Chen Y, Li Y, Huang M, Zhao W (2020b) Geniposide alleviates diabetic nephropathy of mice through AMPK/SIRT1/NF-κB pathway. Eur J Pharmacol 886:173449

    CAS  PubMed  Google Scholar 

  • Li J, Zhao C, Zhu Q, Wang Y, Li G, Li X, Ma C (2021a) Sweroside protects against myocardial ischemia-reperfusion injury by inhibiting oxidative stress and pyroptosis partially via modulation of the keap1/Nrf2 axis. Front Cardiovasc Med. 8:650368

    PubMed  PubMed Central  Google Scholar 

  • Li X, Liu S, Qu L, Chen Y, Yuan C, Qin A, Zou W (2021b) Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases. J Ethnopharmacol 274:114018

    CAS  PubMed  Google Scholar 

  • Lin YC, Chen HY, Hsieh CP, Huang YF, Chang IL (2020a) Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines. Environ Toxicol 35:879–887

    CAS  PubMed  Google Scholar 

  • Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, Pan H (2020b) Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Fronti Immunol. 11:580593

    CAS  Google Scholar 

  • Lin Z, Liu Y, Chen L, Cao S, Huang Y, Yang X, Zuo J (2021) Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets. Sci China Life Sci. https://doi.org/10.1007/s11427-020-1840-1

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu W, Chen P, Deng J, Lv J, Liu J (2017) Resveratrol and polydatin as modulators of Ca2+ mobilization in the cardiovascular system. Ann N Y Acad Sci 1403:82–91

    CAS  PubMed  Google Scholar 

  • Liu Y, Grimm M, Dai WT, Hou MC, Xiao ZX, Cao Y (2020a) CB-Dock: a web server for cavity detection-guided protein-ligand blind docking. Acta Pharmacol Sin 2020(41):138–144

    Google Scholar 

  • Liu YL, Hsu CC, Huang HJ, Chang CJ, Sun SH, Lin AM (2020b) Gallic acid attenuated LPS-induced neuroinflammation: Protein aggregation and necroptosis. Mol Neurobiol 57:96–104

    CAS  PubMed  Google Scholar 

  • Liu Z, Wang J, Zhang Y, Wu D, Li S, Jiang A, Xie G (2021) Pterostilbene exerts hepatoprotective effects through ameliorating LPS/D-Gal-induced acute liver injury in mice. Inflammation 44:526–535

    CAS  PubMed  Google Scholar 

  • Lu C, Chen C, Chen A, Wu Y, Wen J, Huang F, Zeng Z (2020) Oridonin attenuates myocardial ischemia/reperfusion injury via downregulating oxidative stress and NLRP3 inflammasome pathway in mice. Evid-Based Complement Altern Med 2020:7395187

    Google Scholar 

  • Lu Y, Liu Y, Zhou J, Li D, Gao W (2021) Biosynthesis, total synthesis, structural modifications, bioactivity, and mechanism of action of the quinone-methide triterpenoid celastrol. Med Res Rev 41:1022–1060

    CAS  PubMed  Google Scholar 

  • Luo C, Zhang Y, Guo H, Han X, Ren J, Liu J (2020a) Ferulic acid attenuates hypoxia/reoxygenation injury by suppressing mitophagy through the PINK1/Parkin signaling pathway in H9c2 cells. Front Pharmacol 11:103

    CAS  PubMed  PubMed Central  Google Scholar 

  • Luo X, Wu S, Jiang Y, Wang L, Li G, Qing Y, Zhang D (2020b) Inhibition of autophagy by geniposide protects against myocardial ischemia/reperfusion injury. Inte Immunopharmacol. 85:106609

    CAS  Google Scholar 

  • Lv FH, Yin HL, He YQ, Wu HM, Kong J, Chai XY, Zhang SR (2016) Effects of curcumin on the apoptosis of cardiomyocytes and the expression of NF-κB, PPAR-γ and Bcl-2 in rats with myocardial infarction injury. Exp Ther Med 12:3877–3884

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ma LQ, Yu Y, Chen H, Li M, Ihsan A, Tong HY, Gao Y (2018) Sweroside alleviated aconitine-induced cardiac toxicity in H9c2 cardiomyoblast cell line. Front Pharmacol 9:1138

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ma L, Li LY, Zhao TL (2020) Anti-inflammatory effects of ginsenoside Rg3 on the hypertrophic scar formation via the NF-κB/IκB signaling pathway in rabbit ears. Pharmazie 75:102–106

    CAS  PubMed  Google Scholar 

  • Mahmoud AM, Hussein OE, Abd El-Twab SM, Hozayen WG (2019) Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis. Food Funct 10:4593–4607

    CAS  PubMed  Google Scholar 

  • Mangan M, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17:688

    CAS  PubMed  Google Scholar 

  • Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J (2021) Anti-inflammatory action and mechanisms of resveratrol. Molecules 26:229

    CAS  PubMed Central  Google Scholar 

  • Mezzaroma E, Abbate A, Toldo S (2021) NLRP3 inflammasome inhibitors in cardiovascular diseases. Molecules 26:976

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miao J, Zhong J, Lan J, Ye S, Ye P, Li S, Li H (2021) Paeonol attenuates inflammation by confining HMGB1 to the nucleus. J Cell Mol Med 25:2885–2899

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pan XC, Liu Y, Cen YY, Xiong YL, Li JM, Ding YY, Zhang HG (2019) Dual role of triptolide in interrupting the NLRP3 inflammasome pathway to attenuate cardiac fibrosis. Int J Mol Sci 20:360

    PubMed Central  Google Scholar 

  • Panneerselvam L, Raghunath A, Ravi MS, Vetrivel A, Subramaniam V, Sundarraj K, Perumal E (2020) Ferulic acid attenuates arsenic-induced cardiotoxicity in rats. Biotech Appl Biochem 67:186–195

    CAS  Google Scholar 

  • Patel RB, Ter Maaten JM, Ferreira JP, McCausland FR, Shah SJ, Rossignol P, Zannad F (2021) Challenges of cardio-kidney composite outcomes in large-scale clinical trials. Circulation 143:949–958

    PubMed  PubMed Central  Google Scholar 

  • Pellegrini C, Martelli A, Antonioli L, Fornai M, Blandizzi C, Calderone V (2021) NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications. Med Res Rev 41:1890–1926

    CAS  PubMed  Google Scholar 

  • Radan M, Dianat M, Badavi M, Mard SA, Bayati V, Goudarzi G (2019) Gallic acid protects particulate matter (PM10) triggers cardiac oxidative stress and inflammation causing heart adverse events in rats. Environ Sci Pollut Res Int 26:18200–18207

    CAS  PubMed  Google Scholar 

  • Ran X, Yan Z, Yang Y, Hu G, Liu J, Hou S, Fu S (2020) Dioscin improves pyroptosis in LPS-induced mice mastitis by activating AMPK/Nrf2 and inhibiting the NF-κB signaling pathway. Oxid Med Cell Longev 2020:8845521

    PubMed  PubMed Central  Google Scholar 

  • Sharif H, Wang L, Wang WL, Magupalli VG, Andreeva L, Qiao Q, Wu H (2019) Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature 570:338–343

    CAS  PubMed  PubMed Central  Google Scholar 

  • Shen S, He F, Cheng C, Xu B, Sheng J (2021) Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway. Biomed Pharmacother 133:110990

    CAS  PubMed  Google Scholar 

  • Sheng C, Hu F, Wu L (2019) Geniposide alleviates hypoxia-induced injury by down-regulation of lncRNA THRIL in rat cardiomyocytes derived H9c2 cells. Eur J Pharmacol 854:28–38

    CAS  PubMed  Google Scholar 

  • Shi X, Xie X, Sun Y, He H, Huang H, Liu Y, Dai M (2020a) Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223. Eur J Pharmacol 885:173473

    CAS  PubMed  Google Scholar 

  • Shi Y, Wang H, Zheng M, Xu W, Yang Y, Shi F (2020b) Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly. FASEB J 34:208–221

    CAS  PubMed  Google Scholar 

  • Silvis M, Demkes EJ, Fiolet A, Dekker M, Bosch L, van Hout G, de Kleijn D (2021) Immunomodulation of the NLRP3 inflammasome in atherosclerosis, coronary artery disease, and acute myocardial infarction. J Cardiovasc Transl Res 14:23–34

    PubMed  Google Scholar 

  • Song P, Shen DF, Meng YY, Kong CY, Zhang X, Yuan YP, Ma ZG (2020) Geniposide protects against sepsis-induced myocardial dysfunction through AMPKα-dependent pathway. Free Radic Biol Med 152:186–196

    CAS  PubMed  Google Scholar 

  • Sun S, Tuo Q, Li D, Wang X, Li X, Zhang Y, Lin F (2020a) Antioxidant effects of salidroside in the cardiovascular system. Evid-Based Complement Altern Med 2020:9568647

    Google Scholar 

  • Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES (2020b) Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation. Life Sci 245:117362

    CAS  PubMed  Google Scholar 

  • Tan YY, Chen LX, Fang L, Zhang Q (2020) Cardioprotective effects of polydatin against myocardial injury in diabetic rats via inhibition of NADPH oxidase and NF-κB activities. BMC Complement Med Therapies 20:378

    CAS  Google Scholar 

  • Toldo S, Mezzaroma E, Buckley LF, Potere N, Di Nisio M, Biondi-Zoccai G, Abbate A (2021) Targeting the NLRP3 inflammasome in cardiovascular diseases. Pharmacol Therapeutics 236:108053

    Google Scholar 

  • Tong L, Zhao Q, Datan E, Lin GQ, Minn I, Pomper MG, Liu JO (2021) Triptolide: reflections on two decades of research and prospects for the future. Nat Prod Rep 38:843–860

    CAS  PubMed  Google Scholar 

  • Wang C, Sun H, Song Y, Ma Z, Zhang G, Gu X, Zhao L (2015) Pterostilbene attenuates inflammation in rat heart subjected to ischemia-reperfusion: role of TLR4/NF-kappaB signaling pathway. Int J Clin Exp Med 8:1737–1746

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wang SP, Lin SC, Li S, Chao YH, Hwang GY, Lin CC (2016) Potent antiarthritic properties of phloretin in murine collagen-induced arthritis. Evid-Based Complement Altern Med 2016:9831263

    Google Scholar 

  • Wang R, Dong Z, Lan X, Liao Z, Chen M (2019) Sweroside alleviated LPS-induced inflammation via SIRT1 mediating NF-κB and FOXO1 signaling pathways in RAW264.7 cells. Molecules 24:872

    PubMed Central  Google Scholar 

  • Wang C, Li Q, Li T (2020a) Dioscin alleviates lipopolysaccharide-induced acute lung injury through suppression of TLR4 signaling pathways. Exp Lung Res 4:11–22

    Google Scholar 

  • Wang F, Gao Q, Yang J, Wang C, Cao J, Sun J, Fu L (2020b) Artemisinin suppresses myocardial ischemia-reperfusion injury via NLRP3 inflammasome mechanism. Mol Cell Biochem 474:171–180

    CAS  PubMed  Google Scholar 

  • Wang Y, Liu X, Shi H, Yu Y, Yu Y, Li M, Chen R (2020c) NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases. Clin Transl Med 10:91–106

    PubMed  PubMed Central  Google Scholar 

  • Wang J, Cai X, Ma R, Lei D, Pan X, Wang F (2021) Anti-inflammatory effects of sweroside on LPS-induced ALI in mice via activating SIRT1. Inflammation. https://doi.org/10.1007/s10753-021-01473-4

    Article  PubMed  Google Scholar 

  • Wei DZ, Lin C, Huang YQ, Wu LP, Huang MY (2017) Ellagic acid promotes ventricular remodeling after acute myocardial infarction by up-regulating miR-140–3p. Biomed Pharmacother 95:983–989

    CAS  PubMed  Google Scholar 

  • Wen HL, Liang ZS, Zhang R, Yang K (2013) Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol 12:50

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wen Y, Pan MM, Lv LL, Tang TT, Zhou LT, Wang B, Liu BC (2019) Artemisinin attenuates tubulointerstitial inflammation and fibrosis via the NF-κB/NLRP3 pathway in rats with 5/6 subtotal nephrectomy. J Cell Biochem 120:4291–4300

    CAS  PubMed  Google Scholar 

  • Wen Y, Geng L, Zhou L, Pei X, Yang Z, Ding Z (2020) Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-κB pathway. Int Immunopharmacol 85:106653

    CAS  PubMed  Google Scholar 

  • Wu J, Sun C, Wang R, Li J, Zhou M, Yan M, Wang C (2018) Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway. Chem Biol Interact 286:17–25

    CAS  PubMed  Google Scholar 

  • Wu M, Li X, Wang S, Yang S, Zhao R, Xing Y, Liu L (2020) Polydatin for treating atherosclerotic diseases: a functional and mechanistic overview. Biomed Pharmacother 128:110308

    CAS  PubMed  Google Scholar 

  • Wu X, Lin L, Wu H (2021) Ferulic acid alleviates lipopolysaccharide-induced acute lung injury through inhibiting TLR4/NF-κB signaling pathway. J Biochem Mol Toxicol 35:e22664

    CAS  PubMed  Google Scholar 

  • Xiao Z, Liu W, Mu YP, Zhang H, Wang XN, Zhao CQ, Liu P (2020) Pharmacological effects of salvianolic acid B against oxidative damage. Front Pharmacol 11:572373

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yan X, Zhang YL, Zhang L, Zou LX, Chen C, Liu Y, Li HH (2019) Gallic acid suppresses cardiac hypertrophic remodeling and heart failure. Mol Nutr Food Res 63:e1800807

    PubMed  Google Scholar 

  • Yang B, Yan P, Yang GZ, Cao HL, Wang F, Li B (2018) Triptolide reduces ischemia/reperfusion injury in rats and H9C2 cells via inhibition of NF-κB, ROS and the ERK1/2 pathway. Int J Mol Med 41:3127–3136

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yang H, Lv H, Li H, Ci X, Peng L (2019) Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways. Cell Commun Signal 17:62

    PubMed  PubMed Central  Google Scholar 

  • Yang G, Jang JH, Kim SW, Han SH, Ma KH, Jang JK, Lee JY (2020) Sweroside prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome. Int J Mol Sci 21:2790

    CAS  PubMed Central  Google Scholar 

  • Yarmohammadi F, Hayes AW, Karimi G (2021) Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review. Naunyn Schmiedebergs Arch Pharmacol. https://doi.org/10.1007/s00210-021-02072-8

    Article  PubMed  Google Scholar 

  • Ye S, Luo W, Khan ZA, Wu G, Xuan L, Shan P, Liang G (2020) Celastrol attenuates angiotensin II-induced cardiac remodeling by targeting STAT3. Circ Res 126:1007–1023

    CAS  PubMed  Google Scholar 

  • Ying Y, Jin J, Ye L, Sun P, Wang H, Wang X (2018) Phloretin prevents diabetic cardiomyopathy by dissociating Keap1/Nrf2 complex and inhibiting oxidative stress. Front Endocrinol 9:774

    Google Scholar 

  • Ying Y, Jiang C, Zhang M, Jin J, Ge S, Wang X (2019) Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model. Aging 11:2822–2835

    CAS  PubMed  PubMed Central  Google Scholar 

  • Yu Z, Wang S, Zhang X, Li Y, Zhao Q, Liu T (2017) Pterostilbene protects against myocardial ischemia/reperfusion injury via suppressing oxidative/nitrative stress and inflammatory response. Int Immunopharmacol 43:7–15

    CAS  PubMed  Google Scholar 

  • Yu C, Cai X, Liu X, Liu J, Zhu N (2021) Betulin alleviates myocardial ischemia-reperfusion injury in rats via regulating the Siti1/NLRP3/NF-κB signaling pathway. Inflammation 44:1096–1107

    CAS  PubMed  Google Scholar 

  • Zhang LP, Jiang YC, Yu XF, Xu HL, Li M, Zhao XZ, Sui DY (2016) Ginsenoside Rg3 improves cardiac function after myocardial ischemia/reperfusion via attenuating apoptosis and inflammation. Evid-Based Complement Altern Med 2016:6967853

    Google Scholar 

  • Zhang J, Zhou Y, Sun Y, Yan H, Han W, Wang X, Xu X (2019a) Beneficial effects of Oridonin on myocardial ischemia/reperfusion injury: Insight gained by metabolomic approaches. Eur J Pharmacol 861:172587

    CAS  PubMed  Google Scholar 

  • Zhang Z, Li S, Cao H, Shen P, Liu J, Fu Y, Zhang N (2019b) The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice. Food Funct 10:422–431

    CAS  PubMed  Google Scholar 

  • Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J (2018) Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol 16:189–198

    CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng J, Mao Z, Zhang J, Jiang L, Wang N (2020) Paeonol pretreatment attenuates anoxia-reoxygenation induced injury in cardiac myocytes via a BRCA1 dependent pathway. Chem Pharm Bull 68:1163–1169

    CAS  Google Scholar 

  • Zhou W, Chen C, Chen Z, Liu L, Jiang J, Wu Z, Chen Y (2018) NLRP3: a novel mediator in cardiovascular disease. J Immunol Res 2018:5702103

    PubMed  PubMed Central  Google Scholar 

  • Zhou B, Li Q, Wang J, Chen P, Jiang S (2019) Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food Chem Toxicol 123:16–27

    CAS  PubMed  Google Scholar 

Download references

Funding

This work was financially supported by National Natural Science Foundation of China (82004180), Open Fund of State Key Laboratory of Tea Plant Biology and Utilization (SKLTOF20210112), and Key Project Foundation of Natural Science Research of Anhui University of Chinese Medicine (2020zrzd06).

Author information

Author notes

  1. Fang Hua and Lingli Shi have contributed equally to this work.

Authors and Affiliations

  1. Pharmacy School, Anhui Xinhua University, Hefei, 230088, People’s Republic of China

    Fang Hua & Lingli Shi

  2. School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, People’s Republic of China

    Peng Zhou

  3. Institute of Integrated Chinese and Western Medicine, Anhui Academy of Chinese Medicine, Hefei, 230012, People’s Republic of China

    Peng Zhou

Authors
  1. Fang Hua
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lingli Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peng Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

FH and LJS collected the literature materials and wrote the manuscript. PZ designed the study and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Peng Zhou.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hua, F., Shi, L. & Zhou, P. Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases. Inflammopharmacol 30, 137–147 (2022). https://doi.org/10.1007/s10787-021-00918-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10787-021-00918-4

Keywords

Search

Navigation