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Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats

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Abstract

Selenium (Se) is a dietary essential trace element with important biological roles. It is a nutrient related to the complex metabolic and enzymatic functions. Organoselenium compounds have been reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. The antiulcer activity of binapthyl diselenide (NapSe)2 was investigated in ethanol-induced gastric lesions in rats. A number of markers of oxidative stress were examined in rats stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. (NapSe)2 was found to be significantly restoring the deficits in the antioxidant defense mechanisms (CAT, SOD, NPSH and ascorbic acid), and suppressed lipid peroxidation in rat stomach resulting from EtOH administration. It is experimentally concluded that ethanol exposure causes alterations in the antioxidant defense system and induces oxidative stress in rat stomach. These studies establish a promising foundation for investigating and understanding the beneficial effects of organoselenium compounds on human health. Moreover, (NaPSe)2 deserves further investigation as a therapeutic and preventive agent against gastric ulcer in humans.

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Acknowledgments

Mohammad Ibrahim is a beneficiary of the TWAS-CNPq doctoral fellowship program. The Financial support of TWAS-CNPq, is acknowledged.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências Biológicas- Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil

    Mohammad Ibrahim, Niaz Muhammad, Gerlânia de Oliveira Leite & Joao B. T. Rocha

  2. Department of Chemistry, Abdul Wali Khan University Mardan (AWKUM) KPK, Mardan, Pakistan

    Mohammad Ibrahim & Muhammad Ishaq Ali Shah

  3. Department of Chemistry and Division of Biochemistry and Life Science, University of Glasgow, Glasgow, G128QQ, UK

    Musadiq Ibrahim

  4. Department of Chemistry, Kohat University of Science and Technology, Kohat, Khyber Pakhtun Khwa, Pakistan

    Musadiq Ibrahim

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  1. Mohammad Ibrahim
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  2. Musadiq Ibrahim
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  3. Niaz Muhammad
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  4. Muhammad Ishaq Ali Shah
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  5. Gerlânia de Oliveira Leite
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  6. Joao B. T. Rocha
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Correspondence to Mohammad Ibrahim.

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Ibrahim, M., Ibrahim, M., Muhammad, N. et al. Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats. Inflammopharmacol 26, 1117–1123 (2018). https://doi.org/10.1007/s10787-018-0451-7

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  • DOI: https://doi.org/10.1007/s10787-018-0451-7

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