Study of Hepatoprotective and Detoxifying Properties of Plant Antioxidants in Tetrachloromethane-Induced Oxidative Stress

Abstract

Intensification of lipid peroxidation leading to oxidative stress plays an important role in pathogenesis of liver function disorders. The aim of the investigation was to study hepatoprotective effect of strawberry water extract, walnut meal suspension and their mixture in 1:1 ratio as well as quercetin on the model of tetrachloromethane-induced oxidative stress. In the experiment, 180 animals were used, which were divided into 6 groups. The animals in the control group received 1 ml distilled water intragastrically every 30 days prior to the initiation of oxidative stress and for 6 days in parallel with tetrachlormethane injection as an additional load. Animals of 3–6 groups received strawberry aqueous extract, walnut meal suspension, quercetin oil solution and a mixture of walnut meal suspension and strawberry aqueous extract in a dose according to the group affiliation by a similar volume and time interval. CCI4 in the form of 50% oil solution was administered to rats intramuscularly for 6 days. It was established experimentally that strawberry water extract, walnut meal suspension, quercetin and a mixture of strawberry water extract and walnut meal suspension under oxidative stress model in rats possess hepatoprotective and detoxifying properties in different degrees and the most pronounced effect was found when using a mixture of natural antioxidants.