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Molecular-Specific Imaging of Tissue with Photo-Thermal Optical Coherence Tomography

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Abstract

Photo-thermal optical coherence tomography (PT-OCT) is a functional extension of conventional OCT with the ability to generate maps of light absorption co-registered with the micron resolution structural tomograms of OCT. Potentially, signal analysis of such light absorption maps can be used to obtain refined depth-resolved insight into the chemical composition of tissue. Such analysis, however, is complex because the underlying physics of PT-OCT is multifactorial. That is, aside from tissue chemical composition, optical, thermal, and mechanical properties of tissue affect PT-OCT signals; certain system/instrumentation parameters also influence PT-OCT signals. As such, obtaining refined depth-resolved insight into tissue chemical composition requires in-depth understanding of the interplay between sample and system parameters and the induced signals. Moreover, translation of PT-OCT to clinics requires introduction of new experimentation strategies for enhancing the detection specificity and imaging speed of PT-OCT. In this review paper, we present and discuss our recent works aimed at addressing the above theoretical and technological challenges.

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Funding

Natural Sciences and Engineering Research Council of Canada (RGPIN-2022–04605); York University (Lassonde School of Engineering Innovation Fund); National Institutes of Health (P41EB015903).

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Authors and Affiliations

  1. Department of Mechanical Engineering, Lassonde School of Engineering, York University, 4700 Keele St, Toronto, ON, M3J 1P3, Canada

    Mohammadhossein Salimi & Nima Tabatabaei

  2. Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA

    Martin Villiger

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  1. Mohammadhossein Salimi
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Contributions

M.S. developed the system, carried out the experiments, analyzed the data and drafted the manuscript; M.V. and N.T. supervised all aspects of project including the design and development the system, design of experiments, data analysis and edited the manuscript.

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Correspondence to Nima Tabatabaei.

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Salimi, M., Villiger, M. & Tabatabaei, N. Molecular-Specific Imaging of Tissue with Photo-Thermal Optical Coherence Tomography. Int J Thermophys 44, 36 (2023). https://doi.org/10.1007/s10765-022-03135-5

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  • DOI: https://doi.org/10.1007/s10765-022-03135-5

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