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Non-Destructive Evaluation Method of Pharmaceutical Tablet by Terahertz-Time-Domain Spectroscopy: Application to Sound-Alike Medicines

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Abstract

To evaluate terahertz time-domain spectroscopy (THz-TDS) as a promising tool for discriminating pharmaceutical tablets, THz-TDS has been applied for discrimination between pharmaceutical tablets with sound-alike names. Two sets of medicine tablets with sound-alike names, that is, Amaryl and Almarl, Zyloric and Zantac, are examined in this study. Based on the difference in THz absorption spectra, we have succeeded in distinguishing between sound-alike medicine tablets clearly for each set. The results in this study suggest that THz-TDS is a useful tool that is indispensable for medical security maintenance, such as a non-destructive way to prevent mix-up of medicine.

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Authors and Affiliations

  1. Nagahama Institute of Bio-science and Technology, 1266 Tamura, Nagahama, Shiga, 526-0829, Japan

    Masaya Kawase

  2. Research Center for Development of Far-Infrared Region, University of Fukui, 3-9-1 Bunkyo, Fukui, 910-8507, Japan

    Kohji Yamamoto, Keita Takagi, Ryohei Yasuda & Masahiko Tani

  3. Faculty of Pharmaceutical Sciences, Osaka Ohtani University, 3-11-1 Nishikiorikita, Tondabayashi, Osaka, 584-8540, Japan

    Masafumi Ogawa, Yasutoshi Hatsuda, Sonoyo Kawanishi, Yoshihiko Hirotani, Michiaki Myotoku, Yoko Urashima, Katsuhito Nagai, Kenji Ikeda & Hiroki Konishi

  4. Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita, Okayama, 700-8530, Japan

    Junji Yamakawa

Authors
  1. Masaya Kawase
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  2. Kohji Yamamoto
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  3. Keita Takagi
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  4. Ryohei Yasuda
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  5. Masafumi Ogawa
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  6. Yasutoshi Hatsuda
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  7. Sonoyo Kawanishi
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  8. Yoshihiko Hirotani
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  9. Michiaki Myotoku
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  10. Yoko Urashima
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  11. Katsuhito Nagai
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  12. Kenji Ikeda
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  13. Hiroki Konishi
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  14. Junji Yamakawa
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  15. Masahiko Tani
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Corresponding author

Correspondence to Masaya Kawase.

Additional information

Almarl was renamed as arotinolol by many mix-ups at January, 2012.

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Kawase, M., Yamamoto, K., Takagi, K. et al. Non-Destructive Evaluation Method of Pharmaceutical Tablet by Terahertz-Time-Domain Spectroscopy: Application to Sound-Alike Medicines. J Infrared Milli Terahz Waves 34, 566–571 (2013). https://doi.org/10.1007/s10762-013-9994-2

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  • DOI: https://doi.org/10.1007/s10762-013-9994-2

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