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Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress

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Abstract

Neuroinflammation and oxidative stress play critical roles in pathogenesis of depression. Diallyl disulfide (DADS), an active compound in garlic oil, has been shown to exhibit obvious anti-inflammatory and anti-oxidative activities. Preliminary evidence indicates that depression is associated with high levels of pro-inflammatory cytokines and oxidative markers, suggesting that inhibition of neuroinflammatory response and oxidative stress may be beneficial for depression interruption. Here, we investigated the antidepressant effect of DADS as well as it mechanisms in a depression-like model induced by lipopolysaccharide (LPS). Similarly to imipramine (10 mg/kg), a clinical antidepressant, DADS (40 or 80 mg/kg), which was administered 1 h before LPS treatment (pre-LPS) or 1.5 h and 23.5 h after LPS treatment (post-LPS), prevented and reversed LPS (100 μg/kg)-induced increase in immobility time in the tail suspension test (TST) and forced swim test (FST) in mice. Mechanistic studies revealed that DADS pre-treatment or post-treatment at the dose of 40 and 80 mg/kg prevented and reversed (i) LPS-induced increases in interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nitric oxide (NO) levels in the hippocampus and prefrontal cortex, (ii) LPS-induced increases in contents of malondialdehyde (MDA), a parameter reflecting high levels of oxidative stress, and (iii) LPS-induced decreases in contents of GSH, a marker reflecting weakened anti-oxidative ability, in the hippocampus and prefrontal cortex in mice. These results indicate that DADS is comparable to imipramine in effectively ameliorating LPS-induced depression-like behaviors in mice, providing a potential value for DADS in prevention and/or therapy of depression.

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Acknowledgements

The authors would like to thank all the members for the helpful discussions on the manuscript.

Funding

This work was supported by the Natural Science Foundation of China (81771467, 81571323, 81701286, 81974216, and 31771172), the Natural Science Foundation of Jiangsu Province (BK20180267 and BK20191207), and the Six Talent Peaks Project in Jiangsu Province (SWYY-071).

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Author notes

  1. Xiaoyou Wei, Yaoying Ma, Fu Li and Haiyan He contributed equally to this work.

Authors and Affiliations

  1. Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou No.7 People’s Hospital, 288# Yanling East Road, Changzhou, 213000, Jiangsu, China

    Xiaoyou Wei & Fu Li

  2. Department of Pharmacology, School of Pharmacy, Nantong University, 19# Qixiu Road, Nantong, 226001, Jiangsu, China

    Yaoying Ma & Chao Huang

  3. Department of Respiratory Medicine, the Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, #6 North Road Hai’er Xiang, Nantong, 226001, Jiangsu, China

    Haiyan He & Jinliang Chen

  4. Department of Nephrology, the Second Affiliated Hospital of Nantong University, Nantong First People’s Hospital, #6 North Road Hai’er Xiang, Nantong, 226001, Jiangsu, China

    Huaxing Huang

  5. Invasive Technology Department, Nantong First People’s Hospital, the Second Affiliated Hospital of Nantong University, #6 North Road Hai’er Xiang, Nantong, 226001, Jiangsu, China

    Zhuo Chen & Dongjian Chen

  6. Department of Cardiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, #32 Xi’er Duan, 1ST Ring Road, Chengdu, 610072, Sichuan, China

    Xiaomei Yuan

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  9. Jinliang Chen
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  10. Xiaomei Yuan
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Contributions

Conceived and designed the experiments: J. Chen, X. Yuan, and Y. Ma. Performed the experiments: X. Wei, F. Li, H. He, H. Huang, C. Huang, Z. Chen, and D. Chen. Analyzed the data: X. Wei, F. Li, H. He, H. Huang, C. Huang, and Z. Chen. Wrote the paper: X. Wei, F. Li, X. Yuan, and Y. Ma.

Corresponding authors

Correspondence to Jinliang Chen or Xiaomei Yuan.

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Ethics Approval and Consent to Participate

All animal experiments in the present study were approved by the University Animal Ethics Committee of Nantong University (Permit Number: 2110836) and were carried out according to internationally accepted guidelines for the use of animals in toxicology as adopted by the Society of Toxicology in 1999.

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The authors declare no competing interests.

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Wei, X., Ma, Y., Li, F. et al. Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress. Inflammation 44, 1381–1395 (2021). https://doi.org/10.1007/s10753-021-01423-0

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