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The NLRP3 Inflammasome and Its Role in Sepsis Development

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Abstract

The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.

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Authors and Affiliations

  1. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarão, SC, Brazil

    Lucinéia Gainski Danielski, Amanda Della Giustina, Sandra Bonfante & Fabricia Petronilho

  2. Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil

    Tatiana Barichello

  3. Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

    Tatiana Barichello

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Danielski, L.G., Giustina, A.D., Bonfante, S. et al. The NLRP3 Inflammasome and Its Role in Sepsis Development. Inflammation 43, 24–31 (2020). https://doi.org/10.1007/s10753-019-01124-9

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