Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice

Abstract

Oxidative stress and inflammation play an important role in the chronic kidney disease associated with obesity. Resveratrol (RSV) has been reported to exhibit a wide range of biological activities including antioxidant and anti-inflammatory properties. The objective of the present study was to investigate the effects of RSV on renal inflammation and oxidative stress in obese mice induced by high-fat diet. Male C57BL/6 mice were induced to have nephropathy associated obesity by high-fat diet for 12 weeks. After 8 weeks of feeding, oral supplementation with 100 mg RSV/kg body weight/day was applied with the high-fat-diet feeding for another 4 weeks. The results showed that RSV treatment protected against renal damage induced by high-fat diet, as evidenced by the decreased serum creatinine and urea nitrogen levels, alleviation of glomerular damage, and tubular vacuolization. In addition, RSV enhanced the antioxidant enzyme activity; improved the expression of genes related to inflammation; and decreased the malondialdehyde, tumor necrosis factor-α, and interleukin-6 concentrations in the kidney of high-fat-diet mice. In conclusion, RSV could alleviate renal damage in obese mice induced by high-fat diet via suppressing inflammation and oxidative stress.

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Acknowledgments

The present study was supported by the National Natural Science Foundation of China (Grant Nos. 31601948, 31772634, and 31802094), the National Key Research and Development Program of China (Grants No. 2018YFD0501101), the Postdoctoral Research Foundation of China (Grant No. 2018M632320), and the Open Project of Shanghai Key Laboratory of Veterinary Biotechnology (Grant No. klab201710).

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Correspondence to Tian Wang.

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All of the procedures involving mice were carried out in accordance with the Guiding Principles for the Care and Use of Laboratory Animals, China. The experiment performed in the present study was approved by the Animal Care and Use Committee of Nanjing Agricultural University.

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Cheng, K., Song, Z., Chen, Y. et al. Resveratrol Protects Against Renal Damage via Attenuation of Inflammation and Oxidative Stress in High-Fat-Diet-Induced Obese Mice. Inflammation 42, 937–945 (2019). https://doi.org/10.1007/s10753-018-0948-7

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KEY WORDS

  • resveratrol
  • inflammation
  • oxidative stress
  • high-fat diet
  • obesity
  • mice