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Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release

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Abstract

Rheumatoid arthritis is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Eleutheroside E (EE), a principal active constituent of Acanthopanax senticosus, is reported to have anti-inflammatory effect by inhibiting NF-κB activities. However, the effects of EE on rheumatoid arthritis (RA) severity are largely unknown. The purpose of this study was to indicate whether EE could ameliorate arthritis and reduce inflammatory cytokine release in collagen-induced arthritis (CIA) mice. The results showed that EE attenuated the severity of arthritis by reducing the mean arthritis score and arthritis incidence. EE also significantly decreased the inflammatory cell infiltration, pannus formation, cartilage damage, and bone erosion of CIA mice. Furthermore, EE caused a marked decrease of the production of TNF-α and IL-6 in vivo and in vitro. These observations identify a novel function of EE that results in inhibition of cytokine release, highlighting EE was a potential therapeutic agent for RA.

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Acknowledgments

This work was supported by the grants from the National Natural Science Foundation of China (No. 81202348 and No. 81202394) and Jiangsu Province National Natural Science Funds (No. BK2012171) and the Natural Science Research Project of Higher Education of Jiangsu (No. 12KJD310006), the Applied Basic Research Programs of Suzhou Sci-tech Bureau (No. SYS201219), and the Medical Research Projects of Health Department of Jiangsu Province (No. Z201304).

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Authors and Affiliations

  1. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China

    Chunyan He, Xiaohui Chen, Yanyan Qie & Xueming Zhu

  2. Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China

    Chunyang Zhao

  3. Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou, China

    Zhaowei Yan

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  1. Chunyan He
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  2. Xiaohui Chen
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Correspondence to Zhaowei Yan or Xueming Zhu.

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Chunyan He and Xiaohui Chen contributed equally to this work.

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He, C., Chen, X., Zhao, C. et al. Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release. Inflammation 37, 1533–1543 (2014). https://doi.org/10.1007/s10753-014-9880-7

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