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Peri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction

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Abstract

Enhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 ± 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type α (TNF-α; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-α (r = 0.5), delta-TNF-α (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ.

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Acknowledgments

Prof. Sposito was supported by a fellowship grant of productivity in research from the Brazilian National Research Council (CNPq), grant number 300313/2007-1. Dr. Coelho-Filho is a recipient of an AHA Postdoctoral Fellowship Award (AHA 11POST5550053). ACS, ORCF, JCQS, TQ, RM, BA, JMA, ALRA, JAFR, and ORC take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation. RJG collaborated in image processing to estimate the PIZ. MJH collaborated critically reviewing the manuscript. The authors state that they have no conflict of interest.

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Authors and Affiliations

  1. Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil

    Otavio Rizzi Coelho-Filho, Thiago Quinaglia, Rodrigo G. P. Modolo, Breno O. Almeida, Otavio Rizzi Coelho & Andrei C. Sposito

  2. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Otavio Rizzi Coelho-Filho & Michael Jerosch-Herold

  3. University of Brasilia Medical School (UnB), Brasília, DF, Brazil

    Jose C. Quinaglia e Silva & Joalbo M. Andrade

  4. Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Rob J. van der Geest

  5. Hospital de Base do Distrito Federal, Brasilia, DF, Brazil

    Jose C. Quinaglia e Silva

  6. Cardiology Division, Faculty of Medical Sciences, State University of Campinas (UNICAMP), 13084-971, Campinas, Sao Paulo, Brazil

    Andrei C. Sposito

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  1. Jose C. Quinaglia e Silva
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  9. Otavio Rizzi Coelho
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on behalf of the Brasilia Heart Study Group

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Correspondence to Andrei C. Sposito.

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Quinaglia e Silva, J.C., Coelho-Filho, O.R., Andrade, J.M. et al. Peri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction. Inflammation 37, 678–685 (2014). https://doi.org/10.1007/s10753-013-9784-y

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  • DOI: https://doi.org/10.1007/s10753-013-9784-y

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