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Host Modulation in Rheumatoid Arthritis Patients with TNF Blockers Significantly Decreases Biochemical Parameters in Periodontitis

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Abstract

The aim of this study was to evaluate the effects of host modulation therapy on periodontal and biochemical parameters. Sixteen rheumatoid arthritis patients newly scheduled for anti-tumour necrosis factor (TNF) therapy were screened for 30 days. Periodontal parameters (clinical attachment level, probing pocket depth, bleeding on probing, plaque index and gingival index) as well as salivary and gingival crevicular fluid (GCF), interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein-1 (MCP-1) levels of the patients were evaluated at baseline and on the 30th day of therapy. GCF volume, IL-1β and IL-8 levels (p = 0.007, p = 0.017 and p = 0.009, respectively) of the periodontitis patients significantly decreased. Although there was a decrease in all these parameters in healthy patients, it was below statistical significance. Salivary IL-8 and MCP-1 levels significantly decreased in periodontitis patients (p = 0.028 and p = 0.013, respectively), but IL-1β levels remained unchanged. These results suggest that TNF blockers may significantly modify host response in terms of biochemical parameters of the periodontium and may mask significant associations such as those reported between periodontitis and rheumatoid arthritis.

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Acknowledgments

The authors thank Digdem Taskaya, Application Specialist, BD Biosciences, for her valuable support during the biochemical analyses and Yrd.Doç.Dr. Seval Kul for the statistical analysis.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Gaziantep University, 27310, Gaziantep, Turkey

    Kemal Üstün, Kamile Erciyas, Ufuk Sezer & Hasan Gündoğar

  2. Department of Rheumatology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

    Bünyamin Kısacık, Yavuz Pehlivan & Ahmet Mesut Onat

  3. Department of Medical Biology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

    Serdar Öztuzcu

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  1. Kemal Üstün
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  2. Kamile Erciyas
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  5. Yavuz Pehlivan
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Correspondence to Kemal Üstün.

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Üstün, K., Erciyas, K., Kısacık, B. et al. Host Modulation in Rheumatoid Arthritis Patients with TNF Blockers Significantly Decreases Biochemical Parameters in Periodontitis. Inflammation 36, 1171–1177 (2013). https://doi.org/10.1007/s10753-013-9652-9

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  • DOI: https://doi.org/10.1007/s10753-013-9652-9

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