Skip to main content
SpringerLink
Log in

Testing of the iron state in outdated pharmaceuticals using Mössbauer spectroscopy

  • Published:
Hyperfine Interactions Aims and scope Submit manuscript

Abstract

The results of the iron state testing in selected outdated pharmaceuticals by Mössbauer spectroscopy are presented. Pharmaceuticals containing ferrous sulfate and ferrous fumarate demonstrate appearance of small content of ferric compounds and some instability of ferrous sulfate and ferrous fumarate with formation of ferrous compounds. In contrast, pharmaceutical products containing iron chelates show high instability of iron chelates with formation of ferric compounds even in fresh samples with further increase of their content with aging. Iron-polymaltose complexes containing β-FeOOH nanosized cores demonstrate a good stability after expire date.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sud, M., Bala, N., Liveleen, Vishwamittar, Puri, S.P.: Mössbauer spectroscopic study of some medicines containing ferrous sulphate & ferrous fumarate. Indian J. Pure Appl. Phys. 26, 701–704 (1988)

  2. Yang, C.-Y., Bryan, A.M., Theil, E.C., Sayers, D.E., Bowen, L.H.: Structural variations in soluble iron complexes of models for ferritin: an X-ray absorption and Mössbauer spectroscopy comparison of horse spleen ferritin to Blutal (iron-chondroitin sulfate) and Imferon (iron-dextran). J. Inorg. Biochem. 28, 393–405 (1986)

    Article  Google Scholar 

  3. Coe, E.M., Bowen, L.H., Speer, J.A., Wang, Z., Sayers, D.E., Bereman, R.D.: The recharacterization of a polysaccharide iron complex (Niferex). J. Inorg. Biochem. 58, 269–278 (1995)

    Article  Google Scholar 

  4. Coe, E.M., Bowen, L.H., Bereman, R.D.: A Mössbauer and X-ray powder diffraction study of some ferrous hematinics. J. Inorg. Biochem. 58, 291–296 (1995)

    Article  Google Scholar 

  5. Oshtrakh, M.I., Semionkin, V.A., Prokopenko, P.G., Milder, O.B., Livshits, A.B., Kozlov, A.A.: Hyperfine interactions in the iron cores from various pharmaceutically important iron-dextran complexes and human ferritin: a comparative study by Mössbauer spectroscopy. Int. J. Biol. Macromol. 29, 303–314 (2001)

    Article  Google Scholar 

  6. Funk, F., Long, G.J., Hautot, D., Büchi, R., Christl, I., Weidler, P.G.: Physical and chemical characterization of therapeutic iron containing materials: a study of several superparamagnetic drug formulations with the β-FeOOH or ferrihydrite structure. Hyperfine Interact. 136, 73–95 (2001)

    Article  ADS  Google Scholar 

  7. Oshtrakh, M.I., Milder, O.B., Semionkin, V.A.: An analysis of the iron state in iron containing vitamins and dietary supplements by Mössbauer spectroscopy. Anal. Chim. Acta. 506, 155–160 (2004)

    Article  Google Scholar 

  8. Oshtrakh, M.I., Milder, O.B., Semionkin, V.A.: Determination of the iron state in ferrous iron containing vitamins and dietary supplements: application of Mössbauer spectroscopy. J. Pharm. Biomed. Anal. 40, 1281–1287 (2006)

    Article  Google Scholar 

  9. Oshtrakh, M.I., Milder, O.B., Semionkin, V.A.: An analysis of the iron state in ferric and ferrous iron containing pharmaceutical products by Mössbauer spectroscopy. J. Radioanal. Nucl. Chem. 269, 547–533 (2006)

    Article  Google Scholar 

  10. Fodor J.,·Kuzmann E., Vértes A.,·Homonnay Z., Klencsár Z., May Z., Szentmihályi K. Mössbauer characterisation of Fe–polygalacturonate as a medicine for human anaemia: the effect of iron concentration. Hyperfine Interact., 190 (2009) 283–290

    Article  Google Scholar 

  11. Oshtrakh, M.I., Semionkin, V.A., Milder, O.B., Novikov, E.G.: Iron containing vitamins and dietary supplements: control of the iron state using Mössbauer spectroscopy with high velocity resolution. Hyperfine Interact. 190, 67–74 (2009)

    Article  ADS  Google Scholar 

  12. Oshtrakh, M.I., Novikov, E.G., Dubiel, S.M., Semionkin, V.A.: Variations of 57Fe hyperfine parameters in medicaments containing ferrous fumarate and ferrous sulfate. Hyperfine Interact. 197, 287–294 (2010)

    Article  ADS  Google Scholar 

  13. Oshtrakh, M.I., Alenkina, I.V., Dubiel, S.M., Semionkin, V.A.: Structural variations of the iron cores in human liver ferritin and its pharmaceutically important models: a comparative study using Mössbauer spectroscopy with a high velocity resolution. J. Mol. Struct. 993, 287–291 (2011)

    Article  ADS  Google Scholar 

  14. Alenkina, I.V., Oshtrakh, M.I., Klencsár, Z., Kuzmann, E., Chukin, A.V., Semionkin, V.A.: 57Fe Mössbauer spectroscopy and electron paramagnetic resonance studies of human liver ferritin, Ferrum Lek and Maltofer®. Spectrochim. Acta, Part A: Molec. and Biomolec. Spectroscopy. 130, 24–36 (2014)

  15. Kądziołka-Gaweł, M., Michałowska, M.: 57Fe hyperfine parameters in vitamins and dietary supplements. Acta Phys. Pol. A. 127, 653–655 (2015)

  16. Arredondo, P.I.S., Barrero, C.A., Garcia, K.E., Greneche, J.M.: Enhancing the possibilities of 57Fe Mössbauer spectrometry to the study of chemical and physical properties of iron in medicines. Polyhedron. 105, 27–34 (2016)

  17. Uhm, Y.R., Lim, J.C., Choi, S.M.: Analyses of ferrous and ferric state in DynabiTab using Mössbauer spectroscopy. Int. J. Anal. Chem. 9321896 (2017)

  18. Alenkina, I.V., Kovacs, K.V., Felner, I., Kuzmann, E., Klencsár, Z., Oshtrakh, M.I.: Structural and magnetic study of the iron cores in iron(III)-polymaltose pharmaceutical ferritin analogue Ferrifol®. J. Inorg. Biochem. 213, 1112020 (2020)

    Article  Google Scholar 

  19. Uhm, Y.R., Sun, G.-M., Lee, J., Kim, C.S., Kim, S.B.: 57Fe hyperfine parameters of ferrous fumarate in antianemic Aronamin C plus medication. J. Korean Phys. Soc. 79, 205–207 (2021)

  20. Dubiel, S.M., Cieślak, J., Gozdyra, R.: Effect of time and storing conditions on iron forms in ferrous gluconate and Ascofer®. J. Mol. Struct. 991, 171–177 (2011)

    Article  ADS  Google Scholar 

  21. Oshtrakh, M.I., Novikov, E.G., Dubiel, S.M., Semionkin, V.A.: Comparative study of Ascofer® and ferrous gluconate using Mössbauer spectroscopy with a high velocity resolution. Hyperfine Interact. 226, 451–457 (2014)

    Article  ADS  Google Scholar 

  22. Kądziołka-Gaweł, M., Wojtyniak, M.: Stability of ferrous fumarate in medicaments for women: application of Mössbauer spectroscopy. Acta Phys. Pol. A. 129, 1242–1244 (2016)

    Article  ADS  Google Scholar 

  23. Oshtrakh, M.I., Semionkin, V.A.: Mössbauer spectroscopy with a high velocity resolution: advances in biomedical, pharmaceutical, cosmochemical and nanotechnological research. Spectrochim. Acta, Part A: Molec. and Biomolec. Spectroscopy. 100, 78–87 (2013)

    Article  ADS  Google Scholar 

  24. Oshtrakh, M.I., Semionkin, V.A.: Mössbauer spectroscopy with a high velocity resolution: principles and applications. In: Tuček, J., Miglierini, M. (eds.) Proceedings of the International Conference “Mössbauer Spectroscopy in Materials Science 2016”. AIP Conference Proceedings, vol. 1781, p. 020019. AIP Publishing, Melville, New York (2016)

  25. Oshtrakh, M.I., Novikov, E.G., Dubiel, S.M., Semionkin, V.A.: Study of vitamins and dietary supplements containing ferrous fumarate and ferrous sulfate using Mössbauer spectroscopy. In: Tuček, J., Miglierini M. (eds.) Proceedings of the International Conference “Mössbauer Spectroscopy in Materials Science 2010”. AIP Conference Proceedings, vol. 1258, pp. 75–81. Melville, N. Y. (2010) 

  26. Oshtrakh, M.I., Alenkina, I.V., Klencsár, Z., Kuzmann, E., Semionkin, V.A.: Different 57Fe microenvironments in the nanosized iron cores in human liver ferritin and its pharmaceutical analogues on the basis of temperature dependent Mössbauer spectroscopy. Spectrochim. Acta, Part A: Molec. and Biomolec. Spectroscopy. 172, 14–24 (2017)

  27. Alenkina, I.V., Kuzmann, E., Felner, I., Kis, V.K., Oshtrakh, M.I.: Unusual temperature dependencies of Mössbauer parameters of the nanosized iron cores in ferritin and its pharmaceutical analogues. Hyperfine Interact. 242, 9 (2021)

    Article  ADS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Ministry of Science and Higher Education of the Russian Federation, project № FEUZ-2020-0060.

Author information

Authors and Affiliations

  1. Institute of Physics and Technology, Ural Federal University, Ekaterinburg, Russian Federation, 620002

    Danil V. Belyaev, Vladislav S. Moskvitin, Irina V. Alenkina & Michael I. Oshtrakh

  2. M.N. Miheev Institute of Metal Physics of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation, 620108

    Danil V. Belyaev

Authors
  1. Danil V. Belyaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Vladislav S. Moskvitin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Irina V. Alenkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael I. Oshtrakh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael I. Oshtrakh.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Proceedings of the International Conference on the Applications of the Mössbauer Effect (ICAME 2021), 5-10 September 2021, Brasov, Romania

Edited by Victor Kuncser

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Belyaev, D.V., Moskvitin, V.S., Alenkina, I.V. et al. Testing of the iron state in outdated pharmaceuticals using Mössbauer spectroscopy. Hyperfine Interact 242, 39 (2021). https://doi.org/10.1007/s10751-021-01774-y

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10751-021-01774-y

Keywords

Search

Navigation