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Comparison of two pharmaceutical products containing ferrous sulfate using Mössbauer spectroscopy

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Abstract

Two fresh commercial pharmaceutical products containing ferrous sulfate such as Tardyferon® and Fenules® were studied by X-ray diffraction and Mössbauer spectroscopy. The obtained results demonstrated that each product contains iron compounds assigned to (i) FeSO4 × H2O and FeSO4 × 4H2O in Tardyferon® and probably two FeSO4 × H2O compounds with some tiny variations in the iron local microenvironments in Fenules®, and (ii) one ferric compound which was unidentified for Tardyferon® but identified as ferric acidic iron sulfate for Fenules®. A water free ferrous sulfate declared by the manufacturer was not found in Fenules®.

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Acknowledgements

This work was supported by the Ministry of Science and Higher Education of the Russian Federation, project № FEUZ-2023-0013. The research funding for M.I.O. and I.V.A. from the Ministry of Science and Higher Education of the Russian Federation (Ural Federal University Program of Development within the Priority-2030 Program) is gratefully acknowledged. This work was carried out within the Agreement of Cooperation between the Ural Federal University (Ekaterinburg) and the Eötvös Loránd University (Budapest).

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Authors and Affiliations

  1. Department of Experimental Physics, Institute of Physics and Technology, Ural Federal University, Ekaterinburg, 620002, Russian Federation

    Michael I. Oshtrakh, Irina V. Alenkina & Andrey V. Chukin

  2. Laboratory of Nuclear Chemistry, Institute of Chemistry, Eötvös Loránd University, Budapest, Hungary

    Ernő Kuzmann & Zoltán Homonnay

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  1. Michael I. Oshtrakh
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  2. Irina V. Alenkina
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  3. Andrey V. Chukin
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  4. Ernő Kuzmann
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  5. Zoltán Homonnay
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Contributions

M.I.O. wrote the main manuscript text; M.I.O, I.V.A. and A.V.C. carried out measurements; all authors discussed the results and reviewed the manuscript.

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Correspondence to Michael I. Oshtrakh.

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Oshtrakh, M.I., Alenkina, I.V., Chukin, A.V. et al. Comparison of two pharmaceutical products containing ferrous sulfate using Mössbauer spectroscopy. Hyperfine Interact 244, 21 (2023). https://doi.org/10.1007/s10751-023-01835-4

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