Skip to main content

Advertisement

Log in

Exercise-based cardiac rehabilitation in women with heart failure: a review of enrollment, adherence, and outcomes

  • Published:
Heart Failure Reviews Aims and scope Submit manuscript

Abstract

Exercise-based cardiac rehabilitation (CR) is an evidence-based recommendation for patients with stable heart failure (HF). Less clear is how effective exercise-based CR is for women with HF. The aim of this review was to synthesize the evidence for the effects of exercise-based CR on mortality, hospitalizations, exercise capacity, and quality of life (QOL) among women with HF. We identified 18 studies comprising 4917 patients, of which 1714 were women. The interventions evaluated consisted of various combinations of supervised in-hospital and out-patient sessions as well as home-based programs that included aerobic (walking, treadmill, bicycle) and resistance training. The interventions ranged from 12 to 54 weeks, with a frequency of 2–7 sessions per week, lasting from 30 to 105 min per session. Because of a paucity of sex-specific analyses of the outcomes, it was not possible to draw conclusions for women. There was limited evidence for mortality benefit for men or women participating in exercise-based CR. There was more substantial evidence for reductions in hospitalizations for the participants. Generally, exercise training improved exercise capacity. The effects of exercise-based CR on QOL were mixed with most studies favoring CR at 3 months but not at 4, 5, and 12 months. Moreover, generally, the physical dimension of QOL but not the mental dimensions improved. Recommendations for future research to reduce the gap in knowledge about the effects of exercise-based CR for women are offered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Availability of data and materials

This declaration is not relevant to the content of the submitted work.

References

  1. Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge MP, Thacker EL, Virani SS, Voeks JH, Wang NY, Wong ND, Wong SS, Yaffe K, Martin SS, American Heart Association Council on E, Prevention Statistics C, Stroke Statistics S (2023) Heart disease and stroke statistics-2023 update: a report from the American Heart Association. Circulation. https://doi.org/10.1161/CIR.0000000000001123

    Article  Google Scholar 

  2. Heidenreich PA, Bozkurt B, Aguilar D, Allen LA, Byun JJ, Colvin MM, Deswal A, Drazner MH, Dunlay SM, Evers LR, Fang JC, Fedson SE, Fonarow GC, Hayek SS, Hernandez AF, Khazanie P, Kittleson MM, Lee CS, Link MS, Milano CA, Nnacheta LC, Sandhu AT, Stevenson LW, Vardeny O, Vest AR, Yancy CW (2022) 2022 AHA/ACC/HFSA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol 79:1757–1780. https://doi.org/10.1016/j.jacc.2021.12.011

    Article  PubMed  Google Scholar 

  3. Urbich M, Globe G, Pantiri K, Heisen M, Bennison C, Wirtz HS, Di Tanna GL (2020) A systematic review of medical costs associated with heart failure in the USA (2014–2020). Pharmacoeconomics 38:1219–1236. https://doi.org/10.1007/s40273-020-00952-0

    Article  PubMed  PubMed Central  Google Scholar 

  4. Hamo CE, Fonarow GC, Greene SJ, Vaduganathan M, Yancy CW, Heidenreich P, Lu D, Matsouaka RA, DeVore AD, Butler J (2021) Temporal trends in risk profiles among patients hospitalized for heart failure. Am Heart J 232:154–163. https://doi.org/10.1016/j.ahj.2020.11.015

    Article  PubMed  Google Scholar 

  5. Ho JE, Enserro D, Brouwers FP, Kizer JR, Shah SJ, Psaty BM, Bartz TM, Santhanakrishnan R, Lee DS, Chan C, Liu K, Blaha MJ, Hillege HL, van der Harst P, van Gilst WH, Kop WJ, Gansevoort RT, Vasan RS, Gardin JM, Levy D, Gottdiener JS, de Boer RA, Larson MG (2016) Predicting heart failure with preserved and reduced ejection fraction: the international collaboration on heart failure subtypes. Circ Heart Fail 9.  https://doi.org/10.1161/CIRCHEARTFAILURE.115.003116

  6. Lala A, Tayal U, Hamo CE, Youmans Q, Al-Khatib SM, Bozkurt B, Davis MB, Januzzi J, Mentz R, Sauer A, Walsh MN, Yancy C, Gulati M (2022) Sex differences in heart failure. J Card Fail 28:477–498. https://doi.org/10.1016/j.cardfail.2021.10.006

    Article  PubMed  Google Scholar 

  7. van Ommen A, Canto ED, Cramer MJ, Rutten FH, Onland-Moret NC, Ruijter HMD (2022) Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions. BMC Med 20:496. https://doi.org/10.1186/s12916-022-02650-4

    Article  PubMed  PubMed Central  Google Scholar 

  8. Khan SS, Beach LB, Yancy CW (2022) Sex-based differences in heart failure: JACC Focus Seminar 7/7. J Am Coll Cardiol 79:1530–1541. https://doi.org/10.1016/j.jacc.2022.02.013

    Article  PubMed  Google Scholar 

  9. Pepine CJ, Merz CNB, El Hajj S, Ferdinand KC, Hamilton MA, Lindley KJ, Nelson MD, Quesada O, Wenger NK, Fleg JL, College A, of Cardiology Committee on Cardiovascular Disease in W, (2020) Heart failure with preserved ejection fraction: similarities and differences between women and men. Int J Cardiol 304:101–108. https://doi.org/10.1016/j.ijcard.2020.01.003

    Article  PubMed  Google Scholar 

  10. Carnethon MR, Pu J, Howard G, Albert MA, Anderson CAM, Bertoni AG, Mujahid MS, Palaniappan L, Taylor HA Jr, Willis M, Yancy CW, Council AHA, on E, Prevention, Council on Cardiovascular Disease in the Y, Council on C, Stroke N, Council on Clinical C, Council on Functional G, Translational B, Stroke C, (2017) Cardiovascular health in African Americans: a scientific statement from the American Heart Association. Circulation 136:e393–e423. https://doi.org/10.1161/CIR.0000000000000534

    Article  PubMed  Google Scholar 

  11. Sullivan K, Doumouras BS, Santema BT, Walsh MN, Douglas PS, Voors AA, Van Spall HGC (2021) Sex-specific differences in heart failure: pathophysiology, risk factors, management, and outcomes. Can J Cardiol 37:560–571. https://doi.org/10.1016/j.cjca.2020.12.025

    Article  PubMed  Google Scholar 

  12. Dibben G, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, Taylor RS (2021) Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev 11:CD001800. https://doi.org/10.1002/14651858.CD001800.pub4

  13. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL, College A, of Cardiology F, American Heart Association Task Force on Practice G, (2013) 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 62:e147-239. https://doi.org/10.1016/j.jacc.2013.05.019

    Article  PubMed  Google Scholar 

  14. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, Newby LK, Pina IL, Roger VL, Shaw LJ, Zhao D, Beckie TM, Bushnell C, D’Armiento J, Kris-Etherton PM, Fang J, Ganiats TG, Gomes AS, Gracia CR, Haan CK, Jackson EA, Judelson DR, Kelepouris E, Lavie CJ, Moore A, Nussmeier NA, Ofili E, Oparil S, Ouyang P, Pinn VW, Sherif K, Smith SC Jr, Sopko G, Chandra-Strobos N, Urbina EM, Vaccarino V, Wenger NK (2011) Effectiveness-based guidelines for the prevention of cardiovascular disease in women–2011 update: a guideline from the American Heart Association. Circulation 123:1243–1262. https://doi.org/10.1161/CIR.0b013e31820faaf8

    Article  PubMed  PubMed Central  Google Scholar 

  15. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, Burri H, Butler J, Celutkiene J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A, Group ESCSD (2021) 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 42:3599–3726. https://doi.org/10.1093/eurheartj/ehab368

    Article  CAS  Google Scholar 

  16. Baldasseroni S, Pratesi A, Francini S, Pallante R, Barucci R, Orso F, Burgisser C, Marchionni N, Fattirolli F (2016) Cardiac rehabilitation in very old adults: effect of baseline functional capacity on treatment effectiveness. J Am Geriatr Soc 64:1640–1645. https://doi.org/10.1111/jgs.14239

    Article  PubMed  Google Scholar 

  17. Yoo BW, Wenger NK (2019) Gender disparities in cardiac rehabilitation among older women: key opportunities to improve care. Clin Geriatr Med 35:587–594. https://doi.org/10.1016/j.cger.2019.07.012

    Article  PubMed  Google Scholar 

  18. Ritchey MD, Maresh S, McNeely J, Shaffer T, Jackson SL, Keteyian SJ, Brawner CA, Whooley MA, Chang T, Stolp H (2020) Tracking cardiac rehabilitation participation and completion among Medicare beneficiaries to inform the efforts of a national initiative. Circ Cardiovasc Qual Outcomes 13:e005902

  19. de Araujo S, Pio C, Beckie TM, Varnfield M, Sarrafzadegan N, Babu AS, Baidya S, Buckley J, Chen SY, Gagliardi A, Heine M, Khiong JS, Mola A, Radi B, Supervia M, Trani MR, Abreu A, Sawdon JA, Moffatt PD, Grace SL (2020) Promoting patient utilization of outpatient cardiac rehabilitation: a joint International Council and Canadian Association of Cardiovascular Prevention and Rehabilitation position statement. Int J Cardiol 298:1–7. https://doi.org/10.1016/j.ijcard.2019.06.064

    Article  Google Scholar 

  20. Golwala H, Pandey A, Ju C, Butler J, Yancy C, Bhatt DL, Hernandez AF, Fonarow GC (2015) Temporal trends and factors associated with cardiac rehabilitation referral among patients hospitalized with heart failure: findings from Get With The Guidelines-Heart Failure registry. J Am Coll Cardiol 66:917–926. https://doi.org/10.1016/j.jacc.2015.06.1089

    Article  PubMed  Google Scholar 

  21. Vogel B, Acevedo M, Appelman Y, Bairey Merz CN, Chieffo A, Figtree GA, Guerrero M, Kunadian V, Lam CSP, Maas A, Mihailidou AS, Olszanecka A, Poole JE, Saldarriaga C, Saw J, Zuhlke L, Mehran R (2021) The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet 397:2385–2438. https://doi.org/10.1016/S0140-6736(21)00684-X

    Article  PubMed  Google Scholar 

  22. Thomas RJ, Balady G, Banka G, Beckie TM, Chiu J, Gokak S, Ho PM, Keteyian SJ, King M, Lui K, Pack Q, Sanderson BK, Wang TY (2018) 2018 ACC/AHA clinical performance and quality measures for cardiac rehabilitation: a report of the American College of Cardiology/American Heart Association Task Force on Performance Measures. Circ Cardiovasc Qual Outcomes 11:e000037. https://doi.org/10.1161/HCQ.0000000000000037

  23. Peters AE, Keeley EC (2017) Trends and predictors of participation in cardiac rehabilitation following acute myocardial infarction: data from the Behavioral Risk Factor Surveillance System. J Am Heart Assoc 7. https://doi.org/10.1161/JAHA.117.007664

  24. Sun EY, Jadotte YT, Halperin W (2017) Disparities in cardiac rehabilitation participation in the United States: a systematic review and meta-analysis. J Cardiopulm Rehabil Prev 37:2–10. https://doi.org/10.1097/HCR.0000000000000203

    Article  PubMed  Google Scholar 

  25. Oosenbrug E, Marinho RP, Zhang J, Marzolini S, Colella TJ, Pakosh M, Grace SL (2016) Sex differences in cardiac rehabilitation adherence: a meta-analysis. Can J Cardiol 32:1316–1324. https://doi.org/10.1016/j.cjca.2016.01.036

    Article  PubMed  Google Scholar 

  26. Pandey A, Keshvani N, Zhong L, Mentz RJ, Pina IL, DeVore AD, Yancy C, Kitzman DW, Fonarow GC (2021) Temporal trends and factors associated with cardiac rehabilitation participation among Medicare beneficiaries with heart failure. JACC Heart Fail 9:471–481. https://doi.org/10.1016/j.jchf.2021.02.006

    Article  PubMed  Google Scholar 

  27. Beatty AL, Beckie TM, Dodson J, Goldstein CM, Hughes JW, Kraus WE, Martin SS, Olson TP, Pack QR, Stolp H, Thomas RJ, Wu WC, Franklin BA (2023) A new era in cardiac rehabilitation delivery: research gaps, questions, strategies, and priorities. Circulation 147:254–266. https://doi.org/10.1161/CIRCULATIONAHA.122.061046

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Supervia M, Medina-Inojosa JR, Yeung C, Lopez-Jimenez F, Squires RW, Perez-Terzic CM, Brewer LC, Leth SE, Thomas RJ (2017) Cardiac rehabilitation for women: a systematic review of barriers and solutions. Mayo Clin Proc. https://doi.org/10.1016/j.mayocp.2017.01.002

    Article  PubMed  Google Scholar 

  29. Mamataz T, Ghisi GLM, Pakosh M, Grace SL (2021) Nature, availability, and utilization of women-focused cardiac rehabilitation: a systematic review. BMC Cardiovasc Disord 21:459. https://doi.org/10.1186/s12872-021-02267-0

    Article  PubMed  PubMed Central  Google Scholar 

  30. Reza N, Gruen J, Bozkurt B (2022) Representation of women in heart failure clinical trials: barriers to enrollment and strategies to close the gap. Am Heart J Plus 13. https://doi.org/10.1016/j.ahjo.2022.100093

  31. Tahhan AS, Vaduganathan M, Greene SJ, Fonarow GC, Fiuzat M, Jessup M, Lindenfeld J, O’Connor CM, Butler J (2018) Enrollment of older patients, women, and racial and ethnic minorities in contemporary heart failure clinical trials: a systematic review. JAMA Cardiol 3:1011–1019. https://doi.org/10.1001/jamacardio.2018.2559

    Article  PubMed  Google Scholar 

  32. Jin X, Chandramouli C, Allocco B, Gong E, Lam CSP, Yan LL (2020) Women’s participation in cardiovascular clinical trials from 2010 to 2017. Circulation 141:540–548. https://doi.org/10.1161/CIRCULATIONAHA.119.043594

    Article  PubMed  Google Scholar 

  33. Whitelaw S, Sullivan K, Eliya Y, Alruwayeh M, Thabane L, Yancy CW, Mehran R, Mamas MA, Van Spall HGC (2021) Trial characteristics associated with under-enrolment of females in randomized controlled trials of heart failure with reduced ejection fraction: a systematic review. Eur J Heart Fail 23:15–24. https://doi.org/10.1002/ejhf.2034

    Article  PubMed  Google Scholar 

  34. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700. https://doi.org/10.1136/bmj.b2700

  35. O’Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL, Investigators H-A (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301:1439–1450. https://doi.org/10.1001/jama.2009.454

    Article  PubMed  PubMed Central  Google Scholar 

  36. Kitzman DW, Brubaker PH, Morgan TM, Stewart KP, Little WC (2010) Exercise training in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. Circ Heart Fail 3:659–667. https://doi.org/10.1161/CIRCHEARTFAILURE.110.958785

    Article  PubMed  PubMed Central  Google Scholar 

  37. Kitzman DW, Brubaker PH, Herrington DM, Morgan TM, Stewart KP, Hundley WG, Abdelhamed A, Haykowsky MJ (2013) Effect of endurance exercise training on endothelial function and arterial stiffness in older patients with heart failure and preserved ejection fraction: a randomized, controlled, single-blind trial. J Am Coll Cardiol 62:584–592. https://doi.org/10.1016/j.jacc.2013.04.033

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Kitzman DW, Brubaker P, Morgan T, Haykowsky M, Hundley G, Kraus WE, Eggebeen J, Nicklas BJ (2016) Effect of caloric restriction or aerobic exercise training on peak oxygen consumption and quality of life in obese older patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 315:36–46. https://doi.org/10.1001/jama.2015.17346

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Pozehl BJ, McGuire R, Duncan K, Kupzyk K, Norman J, Artinian NT, Deka P, Krueger SK, Saval MA, Keteyian SJ (2018) Effects of the HEART Camp trial on adherence to exercise in patients with heart failure. J Card Fail 24:654–660. https://doi.org/10.1016/j.cardfail.2018.06.007

    Article  PubMed  PubMed Central  Google Scholar 

  40. Kitzman DW, Whellan DJ, Duncan P, Pastva AM, Mentz RJ, Reeves GR, Nelson MB, Chen H, Upadhya B, Reed SD, Espeland MA, Hewston L, O’Connor CM (2021) Physical rehabilitation for older patients hospitalized for heart failure. N Engl J Med 385:203–216. https://doi.org/10.1056/NEJMoa2026141

    Article  PubMed  PubMed Central  Google Scholar 

  41. Davidson PM, Cockburn J, Newton PJ, Webster JK, Betihavas V, Howes L, Owensby DO (2010) Can a heart failure-specific cardiac rehabilitation program decrease hospitalizations and improve outcomes in high-risk patients? Eur J Cardiovasc Prev Rehabil 17:393–402. https://doi.org/10.1097/HJR.0b013e328334ea56

    Article  PubMed  Google Scholar 

  42. Mudge AM, Denaro CP, Scott AC, Meyers D, Adsett JA, Mullins RW, Suna JM, Atherton JJ, Marwick TH, Scuffham P, O’Rourke P (2018) Addition of supervised exercise training to a post-hospital disease management program for patients recently hospitalized with acute heart failure: the EJECTION-HF randomized phase 4 trial. JACC Heart Fail 6:143–152. https://doi.org/10.1016/j.jchf.2017.11.016

    Article  PubMed  Google Scholar 

  43. Smart NA, Haluska B, Jeffriess L, Leung D (2012) Exercise training in heart failure with preserved systolic function: a randomized controlled trial of the effects on cardiac function and functional capacity. Congest Heart Fail 18:295–301. https://doi.org/10.1111/j.1751-7133.2012.00295.x

    Article  PubMed  Google Scholar 

  44. Edelmann F, Gelbrich G, Dungen HD, Frohling S, Wachter R, Stahrenberg R, Binder L, Topper A, Lashki DJ, Schwarz S, Herrmann-Lingen C, Loffler M, Hasenfuss G, Halle M, Pieske B (2011) Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. J Am Coll Cardiol 58:1780–1791. https://doi.org/10.1016/j.jacc.2011.06.054

    Article  PubMed  Google Scholar 

  45. Mueller S, Winzer EB, Duvinage A, Gevaert AB, Edelmann F, Haller B, Pieske-Kraigher E, Beckers P, Bobenko A, Hommel J, Van de Heyning CM, Esefeld K, von Korn P, Christle JW, Haykowsky MJ, Linke A, Wisloff U, Adams V, Pieske B, van Craenenbroeck EM, Halle M, OptimEx-Clin Study G (2021) Effect of high-intensity interval training, moderate continuous training, or guideline-based physical activity advice on peak oxygen consumption in patients with heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 325:542–551. https://doi.org/10.1001/jama.2020.26812

    Article  Google Scholar 

  46. Belardinelli R, Georgiou D, Cianci G, Purcaro A (2012) 10-year exercise training in chronic heart failure: a randomized controlled trial. J Am Coll Cardiol 60:1521–1528. https://doi.org/10.1016/j.jacc.2012.06.036

    Article  PubMed  Google Scholar 

  47. Antonicelli R, Spazzafumo L, Scalvini S, Olivieri F, Matassini MV, Parati G, Del Sindaco D, Gallo R, Lattanzio F (2016) Exercise: a “new drug” for elderly patients with chronic heart failure. Aging (Albany NY) 8:860–872. https://doi.org/10.18632/aging.100901

    Article  PubMed  Google Scholar 

  48. Jolly K, Taylor RS, Lip GY, Davies M, Davis R, Mant J, Singh S, Greenfield S, Ingram J, Stubley J, Bryan S, Stevens A (2009) A randomized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM-CHF) study. Eur J Heart Fail 11:205–213. https://doi.org/10.1093/eurjhf/hfn029

    Article  PubMed  PubMed Central  Google Scholar 

  49. Dalal HM, Taylor RS, Jolly K, Davis RC, Doherty P, Miles J, van Lingen R, Warren FC, Green C, Wingham J, Greaves C, Sadler S, Hillsdon M, Abraham C, Britten N, Frost J, Singh S, Hayward C, Eyre V, Paul K, Lang CC, Smith K (2019) The effects and costs of home-based rehabilitation for heart failure with reduced ejection fraction: the REACH-HF multicentre randomized controlled trial. Eur J Prev Cardiol 26:262–272. https://doi.org/10.1177/2047487318806358

    Article  PubMed  Google Scholar 

  50. Ellingsen O, Halle M, Conraads V, Stoylen A, Dalen H, Delagardelle C, Larsen AI, Hole T, Mezzani A, Van Craenenbroeck EM, Videm V, Beckers P, Christle JW, Winzer E, Mangner N, Woitek F, Hollriegel R, Pressler A, Monk-Hansen T, Snoer M, Feiereisen P, Valborgland T, Kjekshus J, Hambrecht R, Gielen S, Karlsen T, Prescott E, Linke A, Group SHFS (2017) High-intensity interval training in patients with heart failure with reduced ejection fraction. Circulation 135:839–849. https://doi.org/10.1161/CIRCULATIONAHA.116.022924

    Article  Google Scholar 

  51. Chrysohoou C, Tsitsinakis G, Vogiatzis I, Cherouveim E, Antoniou C, Tsiantilas A, Tsiachris D, Dimopoulos D, Panagiotakos DB, Pitsavos C, Koulouris NG, Stefanadis C (2014) High intensity, interval exercise improves quality of life of patients with chronic heart failure: a randomized controlled trial. QJM 107:25–32. https://doi.org/10.1093/qjmed/hct194

    Article  CAS  PubMed  Google Scholar 

  52. Palau P, Dominguez E, Nunez E, Schmid JP, Vergara P, Ramon JM, Mascarell B, Sanchis J, Chorro FJ, Nunez J (2014) Effects of inspiratory muscle training in patients with heart failure with preserved ejection fraction. Eur J Prev Cardiol 21:1465–1473. https://doi.org/10.1177/2047487313498832

    Article  PubMed  Google Scholar 

  53. Pina IL, Bittner V, Clare RM, Swank A, Kao A, Safford R, Nigam A, Barnard D, Walsh MN, Ellis SJ, Keteyian SJ, Investigators H-A (2014) Effects of exercise training on outcomes in women with heart failure: analysis of HF-ACTION (Heart Failure-A Controlled Trial Investigating Outcomes of Exercise TraiNing) by sex. JACC Heart Fail 2:180–186. https://doi.org/10.1016/j.jchf.2013.10.007

    Article  PubMed  Google Scholar 

  54. Green CP, Porter CB, Bresnahan DR, Spertus JA (2000) Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure. J Am Coll Cardiol 35:1245–1255. https://doi.org/10.1016/s0735-1097(00)00531-3

    Article  CAS  PubMed  Google Scholar 

  55. Rector TS, Cohn JN (1992) Assessment of patient outcome with the Minnesota Living with Heart Failure questionnaire: reliability and validity during a randomized, double-blind, placebo-controlled trial of pimobendan. Pimobendan Multicenter Research Group. Am Heart J 124:1017–1025. https://doi.org/10.1016/0002-8703(92)90986-6

    Article  CAS  PubMed  Google Scholar 

  56. Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O’Connor CM, Weinfurt KP, Investigators H-A (2009) Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301:1451–1459. https://doi.org/10.1001/jama.2009.457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Alonso WW, Kupzyk KA, Norman JF, Lundgren SW, Fisher A, Lindsey ML, Keteyian SJ, Pozehl BJ (2022) The HEART Camp exercise intervention improves exercise adherence, physical function, and patient-reported outcomes in adults with preserved ejection fraction heart failure. J Card Fail 28:431–442. https://doi.org/10.1016/j.cardfail.2021.09.003

    Article  PubMed  Google Scholar 

  58. Hammill BG, Curtis LH, Schulman KA, Whellan DJ (2010) Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation 121:63–70. https://doi.org/10.1161/CIRCULATIONAHA.109.876383

    Article  PubMed  Google Scholar 

  59. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS (2009) Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 54:25–33. https://doi.org/10.1016/j.jacc.2009.01.078

    Article  PubMed  Google Scholar 

  60. Thygesen LC, Zinckernagel L, Dalal H, Egstrup K, Glumer C, Gronbaek M, Holmberg T, Kober L, la Cour K, Nakano A, Nielsen CV, Sibilitz KL, Tolstrup JS, Zwisler AD, Taylor RS (2022) Cardiac rehabilitation for patients with heart failure: association with readmission and mortality risk. Eur Heart J Qual Care Clin Outcomes 8:830–839. https://doi.org/10.1093/ehjqcco/qcab086

    Article  PubMed  Google Scholar 

  61. De Feo S, Tramarin R, Ambrosetti M, Riccio C, Temporelli PL, Favretto G, Furgi G, Griffo R (2012) Gender differences in cardiac rehabilitation programs from the Italian survey on cardiac rehabilitation (ISYDE-2008). Int J Cardiol 160:133–139. https://doi.org/10.1016/j.ijcard.2011.04.011

    Article  PubMed  Google Scholar 

  62. Giuliano C, Vicendese D, Vogrin S, Lane R, Driscoll A, Dinh D, Palmer K, Levinger I, Neil C (2022) Predictors of referral to cardiac rehabilitation in patients following hospitalisation with heart failure: a multivariate regression analysis. J Clin Med 11. https://doi.org/10.3390/jcm11051232

  63. Park LG, Schopfer DW, Zhang N, Shen H, Whooley MA (2017) Participation in cardiac rehabilitation among patients with heart failure. J Card Fail 23:427–431. https://doi.org/10.1016/j.cardfail.2017.02.003

    Article  PubMed  PubMed Central  Google Scholar 

  64. Colella TJ, Gravely S, Marzolini S, Grace SL, Francis JA, Oh P, Scott LB (2015) Sex bias in referral of women to outpatient cardiac rehabilitation? A meta-analysis. Eur J Prev Cardiol 22:423–441. https://doi.org/10.1177/2047487314520783

    Article  PubMed  Google Scholar 

  65. Samayoa L, Grace SL, Gravely S, Scott LB, Marzolini S, Colella TJ (2014) Sex differences in cardiac rehabilitation enrollment: a meta-analysis. Can J Cardiol 30:793–800. https://doi.org/10.1016/j.cjca.2013.11.007

    Article  PubMed  Google Scholar 

  66. Long L, Mordi IR, Bridges C, Sagar VA, Davies EJ, Coats AJ, Dalal H, Rees K, Singh SJ, Taylor RS (2019) Exercise-based cardiac rehabilitation for adults with heart failure. Cochrane Database Syst Rev 1:CD003331.  https://doi.org/10.1002/14651858.CD003331.pub5

  67. Bjarnason-Wehrens B, Nebel R, Jensen K, Hackbusch M, Grilli M, Gielen S, Schwaab B, Rauch B, German Society of Cardiovascular P, Rehabilitation (2020) Exercise-based cardiac rehabilitation in patients with reduced left ventricular ejection fraction: the Cardiac Rehabilitation Outcome Study in Heart Failure (CROS-HF): a systematic review and meta-analysis. Eur J Prev Cardiol 27:929–952. https://doi.org/10.1177/2047487319854140

    Article  Google Scholar 

  68. Leggio M, Fusco A, Loreti C, Limongelli G, Bendini MG, Mazza A, Coraci D, Padua L (2020) Effects of exercise training in heart failure with preserved ejection fraction: an updated systematic literature review. Heart Fail Rev 25:703–711. https://doi.org/10.1007/s10741-019-09841-x

    Article  CAS  PubMed  Google Scholar 

  69. Fukuta H, Goto T, Wakami K, Kamiya T, Ohte N (2019) Effects of exercise training on cardiac function, exercise capacity, and quality of life in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials. Heart Fail Rev 24:535–547. https://doi.org/10.1007/s10741-019-09774-5

    Article  PubMed  Google Scholar 

  70. Morgan H, Sinha A, McEntegart M, Hardman SM, Perera D (2022) Evaluation of the causes of sex disparity in heart failure trials. Heart 108:1547–1552. https://doi.org/10.1136/heartjnl-2021-320696

    Article  PubMed  Google Scholar 

  71. van Diemen J, Verdonk P, Chieffo A, Regar E, Mauri F, Kunadian V, Sharma G, Mehran R, Appelman Y (2021) The importance of achieving sex- and gender-based equity in clinical trials: a call to action. Eur Heart J 42:2990–2994. https://doi.org/10.1093/eurheartj/ehab457

    Article  PubMed  PubMed Central  Google Scholar 

  72. Eliya Y, Whitelaw S, Thabane L, Voors AA, Douglas PS, Van Spall HGC (2021) Temporal trends and clinical trial characteristics associated with the inclusion of women in heart failure trial steering committees: a systematic review. Circ Heart Fail 14:e008064. https://doi.org/10.1161/CIRCHEARTFAILURE.120.008064

  73. Reza N, Tahhan AS, Mahmud N, DeFilippis EM, Alrohaibani A, Vaduganathan M, Greene SJ, Ho AH, Fonarow GC, Butler J, O’Connor C, Fiuzat M, Vardeny O, Pina IL, Lindenfeld J, Jessup M (2020) Representation of women authors in international heart failure guidelines and contemporary clinical trials. Circ Heart Fail 13:e006605. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006605

  74. Streed C Jr, Caceres B, Mukherjee M (2021) Preventing cardiovascular disease among sexual and gender minority persons. Heart. https://doi.org/10.1136/heartjnl-2021-319069

    Article  PubMed  Google Scholar 

  75. Thompson DR, Clark AM (2020) Heart failure disease management interventions: time for a reappraisal. Eur J Heart Fail 22:578–580. https://doi.org/10.1002/ejhf.1777

    Article  PubMed  Google Scholar 

  76. Thompson DR, Ski CF, Clark AM (2019) Transitional care interventions for heart failure: what are the mechanisms? Am J Med 132:278–280. https://doi.org/10.1016/j.amjmed.2018.09.028

    Article  PubMed  Google Scholar 

  77. Bozkurt B, Fonarow GC, Goldberg LR, Guglin M, Josephson RA, Forman DE, Lin G, Lindenfeld J, O’Connor C, Panjrath G, Pina IL, Shah T, Sinha SS, Wolfel E, Failure ACsH, Transplant S, Leadership C (2021) Cardiac rehabilitation for patients with heart failure: JACC Expert Panel. J Am Coll Cardiol 77:1454–1469. https://doi.org/10.1016/j.jacc.2021.01.030

    Article  PubMed  Google Scholar 

  78. van Halewijn G, Deckers J, Tay HY, van Domburg R, Kotseva K, Wood D (2017) Lessons from contemporary trials of cardiovascular prevention and rehabilitation: a systematic review and meta-analysis. Int J Cardiol 232:294–303. https://doi.org/10.1016/j.ijcard.2016.12.125

    Article  PubMed  Google Scholar 

  79. Francis T, Kabboul N, Rac V, Mitsakakis N, Pechlivanoglou P, Bielecki J, Alter D, Krahn M (2019) The effect of cardiac rehabilitation on health-related quality of life in patients with coronary artery disease: a meta-analysis. Can J Cardiol 35:352–364. https://doi.org/10.1016/j.cjca.2018.11.013

    Article  PubMed  Google Scholar 

  80. Beckie TM, Beckstead JW (2010) Predicting cardiac rehabilitation attendance in a gender-tailored randomized clinical trial. J Cardiopulm Rehabil Prev 30:147–156. https://doi.org/10.1097/HCR.0b013e3181d0c2ce

    Article  PubMed  PubMed Central  Google Scholar 

  81. Ghisi GLM, Kin SMR, Price J, Beckie TM, Mamataz T, Naheed A, Grace SL (2022) Women-focused cardiovascular rehabilitation: an International Council of Cardiovascular Prevention and Rehabilitation clinical practice guideline. Can J Cardiol 38:1786–1798. https://doi.org/10.1016/j.cjca.2022.06.021

    Article  PubMed  Google Scholar 

  82. Beckie TM, Beckstead JW, Schocken DD, Evans ME, Fletcher GF (2011) The effects of a tailored cardiac rehabilitation program on depressive symptoms in women: a randomized clinical trial. Int J Nurs Stud 48:3–12. https://doi.org/10.1016/j.ijnurstu.2010.06.005

    Article  PubMed  Google Scholar 

  83. Beckie TM, Beckstead JW (2010) The effects of a cardiac rehabilitation program tailored for women on global quality of life: a randomized clinical trial. J Womens Health (Larchmt) 19:1977–1985. https://doi.org/10.1089/jwh.2010.1937

    Article  PubMed  Google Scholar 

  84. Taylor RS, Dalal HM, McDonagh STJ (2022) The role of cardiac rehabilitation in improving cardiovascular outcomes. Nat Rev Cardiol 19:180–194. https://doi.org/10.1038/s41569-021-00611-7

    Article  PubMed  Google Scholar 

  85. Thomas RJ, Beatty AL, Beckie TM, Brewer LC, Brown TM, Forman DE, Franklin BA, Keteyian SJ, Kitzman DW, Regensteiner JG, Sanderson BK, Whooley MA (2019) Home-based cardiac rehabilitation: a scientific statement from the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology. Circulation 140:e69–e89. https://doi.org/10.1161/CIR.0000000000000663

    Article  PubMed  Google Scholar 

  86. Anderson L, Sharp GA, Norton RJ, Dalal H, Dean SG, Jolly K, Cowie A, Zawada A, Taylor RS (2017) Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev 6:CD007130. https://doi.org/10.1002/14651858.CD007130.pub4

  87. Beatty AL, Brown TM, Corbett M, Diersing D, Keteyian SJ, Mola A, Stolp H, Wall HK, Sperling LS (2021) Million Hearts Cardiac Rehabilitation Think Tank: accelerating new care models. Circ Cardiovasc Qual Outcomes 14:e008215. https://doi.org/10.1161/CIRCOUTCOMES.121.008215

  88. Lau ES, Cunningham T, Hardin KM, Liu E, Malhotra R, Nayor M, Lewis GD, Ho JE (2020) Sex differences in cardiometabolic traits and determinants of exercise capacity in heart failure with preserved ejection fraction. JAMA Cardiol 5:30–37. https://doi.org/10.1001/jamacardio.2019.4150

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Each author contributed equally to the conceptualization, data collection, data synthesis, and writing and reviewing of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Theresa M. Beckie.

Ethics declarations

Ethical approval

This declaration is not relevant to the content of the submitted work.

Competing interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 14 KB)

Supplementary file2 (DOCX 82 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wills, W.B., Athilingam, P. & Beckie, T.M. Exercise-based cardiac rehabilitation in women with heart failure: a review of enrollment, adherence, and outcomes. Heart Fail Rev 28, 1251–1266 (2023). https://doi.org/10.1007/s10741-023-10306-5

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10741-023-10306-5

Keywords

Navigation