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Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

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Abstract

Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-α) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway. Given the key role of clusterin in preventing loss of cardiac tissue, modulating the expression and function of this protein carries the potential of improving cardiovascular care in the future.

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Acknowledgements

We would like to thank the Brazilian foundations Fundação de Amparo à Pesquisa do Estado de São Paulo and FAEPEX for their indispensable support.

Funding

This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (grant numbers: 2015/07199-2 and 2016/12569-6) and FAEPEX.

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Authors and Affiliations

  1. Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Science, University of Campinas, 1300 Pedro Zaccaria St, Limeira, São Paulo, Brazil

    Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, Dennys Esper Cintra, José Rodrigo Pauli & Leandro Pereira de Moura

  2. CEPECE—Center of Research in Sport Sciences, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil

    Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, José Rodrigo Pauli & Leandro Pereira de Moura

  3. Department of Pharmaceutical Business and Administrative Sciences, MCPHS University, Boston, MA, USA

    Rania A. Mekary

  4. Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Rania A. Mekary

  5. School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil

    Adelino Sanchez Ramos da Silva

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  1. Rodrigo Martins Pereira
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Correspondence to Leandro Pereira de Moura.

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Pereira, R.M., Mekary, R.A., da Cruz Rodrigues, K.C. et al. Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes. Heart Fail Rev 23, 123–129 (2018). https://doi.org/10.1007/s10741-017-9654-z

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