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Alternative therapies for diabetes and its cardiac complications: role of vanadium

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Abstract

It is now well known that a cardiomyopathic state accompanies diabetes mellitus. Although insulin injections and conventional hypoglycemic drug therapy have been of invaluable help in reducing cardiac damage and dysfunction in diabetes, cardiac failure continues to be a common cause of death in the diabetic population. The use of alternative medicine to maintain health and treat a variety of diseases has achieved increasing popularity in recent years. The goal of alternative therapies in diabetic patients has been to lower circulating blood glucose levels and thereby treat diabetic complications. This paper will focus its discussion on the role of vanadium on diabetes and the associated cardiac dysfunction. Careful administration of a variety of forms of vanadium has produced impressive long-lasting control of blood glucose levels in both Type 1 and Type 2 diabetes in animals. This has been accompanied by, in many cases, a complete correction of the diabetic cardiomyopathy. The oral delivery of vanadium as a vanadate salt in the presence of tea has produced particularly impressive hypoglycemic effects and a restoration of cardiac function. This intriguing approach to the treatment of diabetes and its complications, however, deserves further intense investigation prior to its use as a conventional therapy for diabetic complications due to the unknown long-term effects of vanadium accumulation in the heart and other organs of the body.

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References

  1. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC (1998) Trends in alternative medicine use in the United States, 1990–1997. JAMA 280:1569–1575

    CAS  PubMed  Google Scholar 

  2. Grauds C (1997) Botanicals: strong medicine for health and profit. Assoc Natl Med Pharm 3:1

    Google Scholar 

  3. Vann A (1998) The herbal medicine boom: understanding what patients are taking. Cleveland Clin J Med 65(3):129–134

    CAS  Google Scholar 

  4. Harris WS, Isley WL (2001) Clinical trial evidence for the cardioprotective effects of omega-3 fatty acids. Curr Atheroscler Rep 3(2):174–179

    CAS  PubMed  Google Scholar 

  5. Peirce A (1999) Natural medicines. Stonesong Press, New York

    Google Scholar 

  6. Harbowy ME, Balentine DA (1997) Tea Chemistry. Crit Rev Plant Sci 16(5):415–480

    CAS  Google Scholar 

  7. Beart JE, Lilley TH, Haslam E (1985) Plant polyphenols: secondary metabolism and chemical defence. Phytochem 24:33–38

    CAS  Google Scholar 

  8. Dufresne CJ, Farnworth ER (2001) A review of latest research findings on the health promotion properties of tea. J Nutr Biochem 12(7):404–421

    CAS  PubMed  Google Scholar 

  9. Zeyuan D, Bingying TXL, Jinming C, Yifeng C (1998) Effect of green tea and black tea on the blood glucose, the blood triglycerides, and antioxidation in aged rats. J Agric Food Chem 46:875–878

    Google Scholar 

  10. Shimizu M (1999) Modulation of the intestinal function by food substances. Nahrung 43:154–158

    CAS  PubMed  Google Scholar 

  11. Wiseman SA, Balentine DA, Frei B (1997) Antioxidants in tea. Crit Rev Food Sci Nutr 37:705–718

    CAS  PubMed  Google Scholar 

  12. Vinson JA, Jang J, Dabbagh YA, Serry M, Cai S (1995) Plant polyphenols exhibit lipoprotein bound antioxidant activity using an in vitro oxidation model for heart disease. J Agric Food Chem 43:2798–2799

    CAS  Google Scholar 

  13. Yokozawa T, Dong E, Nakagawa T, Kim DW, Hatori M, Nakagawa H (1998) Effects of Japanese black tea on atherosclerotic disorders. Biosci Biotechnol Biochem 62(1):44–48

    CAS  PubMed  Google Scholar 

  14. Yokozawa T, Oura H, Nakagawa H, Sakanaka S, Kim M (1995) Effects of a component of green tea on the proliferation of vascular smooth muscle cells. Biosci Biotechnol Biochem 59(11):2134–2136

    CAS  PubMed  Google Scholar 

  15. Pearson DA, Frankel EN, Aeschbach R, German JB (1998) Inhibition of endothelial cell mediated low-density lipoprotein oxidation by green tea extracts. J Agric Food Chem 62:44–48

    Google Scholar 

  16. Yang TT, Koo MW (1997) Hypocholesterolemic effects of Chinese tea. Pharmacol Res 35(6):505–512

    CAS  PubMed  Google Scholar 

  17. Lin YL, Cheng CY, Lin YP, Lau YW, Lau YW, Juan IM, Lin JK (1998) Hypolipidemic effect of green tea leaves through induction of anti-oxidant and phase II enzymes including superoxide dismutase, catalase and glutathione S-transferase in rats. J Agric Food Chem 46:1893–1899

    CAS  Google Scholar 

  18. Deniset JF, Pierce GN (2010) The value of therapeutic interventions in disrupting Chlamydophila pneumonia involvement in cardiovascular disease. Fundamental Clin Pharmacol 24:607–617

    CAS  Google Scholar 

  19. Tijburg LB, Mattern T, Folts JD, Weisgerber UM, Katan MB (1997) Tea flavonoids and cardiovascular disease: a review. Crit Rev Food Sci Nutr 37(8):771–785

    CAS  PubMed  Google Scholar 

  20. Tijburg LGM, Chio JH, Rhee SJ (1999) Effects of green tea catechin on phospholipase A2 activity and antithrombus in streptozotocin diabetic rats. J Nutr Sci Vitaminol 45:337–346

    Google Scholar 

  21. Yokozawa T, Chung HY, He LQ, Oura H (1996) Effectiveness of green tea tannin on rats with chronic renal failure. Biosci Biotechnol Biochem 60(6):1000–1005

    CAS  PubMed  Google Scholar 

  22. Yokozawa T, Oura H, Sakanaka S, Ishigaki S, Kim M (1994) Depressor effect of tannin in green tea on rats with renal hypertension. Biosci Biotech Biochem 58:855–858

    CAS  Google Scholar 

  23. Yokozawa T, Nakagawa T, Lee KI, Cho EJ, Terasawa K, Takeuchi S (1999) Effects of green tea tannin on cisplatin-induced nephropathy in LLD-PK1 cells and rats. J Pharm Pharmacol 51(11):1325–1331

    CAS  PubMed  Google Scholar 

  24. Hindmarch I, Quinlan PT, Moore KL, Parkin C (1998) The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacology 139(3):230–238

    CAS  PubMed  Google Scholar 

  25. Joseph JA, Denisova N, Fisher D, Shukitt-Hale B, Bickford P, Prior R, Cao G (1998) Membrane and receptor modifications of oxidative stress vulnerability in aging: nutritional considerations. Ann N Y Acad Sci 854:268–276

    CAS  PubMed  Google Scholar 

  26. Junuja LR, Chu DC, Ocubo T, Nagato Y, Yokogoshi H (1999) L-theanine-a unique amino acid of green tea and its effects in humans. Trends Food Sci Technol 10:199–204

    Google Scholar 

  27. Nriagu Jo (1998) Vanadium in the environment. In: Advances in environmental science and technology, Vol. 30, 31. Wiley, New York

  28. Tracey AS, Crans DC (1998) Vanadium compounds. Chemistry, biochemistry and therapeutic applications. Oxford University Press, London

    Google Scholar 

  29. Harland BF, Harden-Williams BA (1994) Is vanadium of human nutritional importance yet? J Am Diet Assoc 94(8):891–894

    CAS  PubMed  Google Scholar 

  30. French RJ, Jones PJ (1993) Role of vanadium in nutrition: metabolism, essentiality and dietary considerations. Life Sci 52(4):339–346

    CAS  PubMed  Google Scholar 

  31. Anke M, Groppel B, Gruhn K, Kosla T, Szilagyi M (1986) In: Anke M, Baumann W, Braunlich H, Bruckner C, Groppel B (eds) Spurenelement-symposium New Trace Elements, Friedrich-Schiller-Universitat Jena, pp 1266–1275

  32. Nielsen FH, Poellot RA, Uthus EO (1997) FASEB J 11: A148 (abs862)

  33. Nielsen FH (1995) Vanadium and its role in life. In: Sigel H, Sigel A (eds) Metal ions and biological systems, vol 31. Marcel Dekkar, New York, pp 543–573

    Google Scholar 

  34. Ikebe K, Tanaka R (1979) Determination of vanadium and nickel in marine samples by flameless and flame atomic absorption spectrophotometry. Bull Environ Contam Toxicol 21(4–5):526–532

    CAS  PubMed  Google Scholar 

  35. Myron DR, Givand SH, Nielsen FH (1977) Vanadium content of selected foods as determined by flameless atomic absorption spectroscopy. J Agric Food Chem 25(2):297–300

    CAS  PubMed  Google Scholar 

  36. Byrne AR, Kosta L (1978) Vanadium in foods and in human body fluids and tissues. Sci Total Environ 10(1):17–30

    CAS  PubMed  Google Scholar 

  37. Nielsen FH (1995) Metal-ligand interactions in biological fluids, bioinorganic medicine, Vol 1. Marcel Dekkar, New York, pp 425–427

    Google Scholar 

  38. Bodgen JD, Higashino H, Lavenhar MA, Bauman Jw Jr, Kemp FW, Aviv A (1982) Balance and tissue distribution of vanadium after short-term ingestion of vanadate. J Nutr 10(2):233–245

    Google Scholar 

  39. Wiegmann TB, Day HD, Patak RV (1982) Intestinal absorption and secretion of radioactive vanadium *48VO3) in rats and effect of Al(OH)3. J Toxicol Environ Health 10(2):233–245

    CAS  PubMed  Google Scholar 

  40. Chasteen ND, Lord EM, Thompson HF (1986) In Frontiers in Bioinorganic Chemistry; Xavier AV (ed) VCH Verlagsgesellschaft, Weinhem, FRG, pp 133–41

  41. Cantley LC Jr, Resh MD, Guidotti G (1978) Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side. Nature 272(5653):552–554

    CAS  PubMed  Google Scholar 

  42. Chasteen ND, Lord EM, Thompson HJ, Grady JK (1986) Vanadium complexes of transferrin and ferritin in the rat. Biochem Biophys Acta 884(1):84–92

    CAS  PubMed  Google Scholar 

  43. Sabbioni E, Marafante E (1981) In: Howell J, Gawthorne JM, White CL (eds) Trace element metabolism in man and animals (TEMA-4). Australian Academy of Science, Canberra, pp 629–631

    Google Scholar 

  44. Patterson BW, Hansard SL 2nd, Ammerman CB, Henry PR, Zech LA, Fisher WR (1986) Kinetic model of whole-body vanadium metabolism: studies in sheep. Am J Physiol 251(2 Pt 2):R325–R332

    CAS  PubMed  Google Scholar 

  45. Hopkins LL Jr, Tilton BE (1966) Metabolism of trace amounts of vanadium 48 in rat organs and liver subcellular particles. Am J Physiol 211(1):169–172

    CAS  PubMed  Google Scholar 

  46. Poucheret P, Verma S, Grynpas MD, McNeill JH (1998) Vanadium and diabetes. Mol Cell Biochem 188(1–2):73–80

    CAS  PubMed  Google Scholar 

  47. Shisheva A, Ikonomov O, Shechter Y (1994) The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats. Endocrinology 134(1):507–510

    CAS  PubMed  Google Scholar 

  48. Stern A, Yin X, Tsang SS, Davison A, Moon J (1993) Vanadium as a modulator of cellular regulatory cascades and oncogene expression. Biochem Cell Biol 71(3–4):103–112

    CAS  PubMed  Google Scholar 

  49. Sekar N, Li J, Shechter Y (1996) Vanadium salts as insulin substitutes: mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research. Crit Rev Biochem Mol Biol 31(5–6):339–359

    CAS  PubMed  Google Scholar 

  50. Want H, Scott RE (1995) Unique and selective mitogenic effects of vanadate on SV40-transformed cells. Mol Cell Biochem 153(1–2):59–67

    Google Scholar 

  51. Sabbioni E, Pozzi G, Pintar A, Casella L, Garattini S (1991) Cellular retention, cytotoxicity and morphological transformation by vanadium(IV) and vanadium (V) in BALB/3T3 cell lines. Carcinogenesis 12(1):47–52

    CAS  PubMed  Google Scholar 

  52. Sabbioni E, Pozzi G, Devos S, Pintar A, Casella L, Fischbach M (1993) The intensity of vanadium(V)-induced cytotoxicity and morphological transformation in BALB/3T3 cells is dependent on glutathione-mediated bioreduction to vanadium(IV). Carcinogenesis 14(12):2565–2568

    CAS  PubMed  Google Scholar 

  53. Etcheverry SB, Crans DC, Keramidas AD, Cortizo AM (1997) Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture. Arch Biochem Biophys 338(1):7–14

    CAS  PubMed  Google Scholar 

  54. Barrio DA, Braziunas MD, Etcheverry SB, Cortizo AM (1997) Maltol complexes of vanadium (IV) and (V) regulate in vitro alkaline phosphatase activity and osteoblast-like cell growth. J Trace Elem Med Biol 11(2):110–115

    CAS  PubMed  Google Scholar 

  55. Cortizo AM, Salice VC, Vescina CM, Etcheverry SB (1997) Proliferative and morphological changes induced by vanadium compounds on Swiss 3T3 fibroblasts. Biometals 10(2):127–133

    CAS  PubMed  Google Scholar 

  56. Cortizo AM, Etcheverry SB (1995) Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells. Mol Cell Biochem 145(2):97–102

    CAS  PubMed  Google Scholar 

  57. Shecter Y, Shisheva A (1993) Vanadium salts and the future treatment of diabetes. Endeavour 17(1):27–31

    Google Scholar 

  58. McNeill JH, Yuen VG, Dai S, Orvig C (1995) Increased potency of vanadium using organic ligands. Mol Cell Biochem 153(1–2):175–180

    CAS  PubMed  Google Scholar 

  59. Cam MC, Cros GH, Serrano JJ, Lazaro R, McNeill JH (1993) In vivo antidiabetic actions of naglivan, an organic vanadyl compound in streptozotocin-induced diabetes. Diabetes Res Clin Pract 29(2):111–121

    Google Scholar 

  60. Reul BA, Amin SS, Buchet JP, Ongemba LN, Crans DC, Brichard SM (1999) Effects of vanadium complexes with organic ligands on glucose metabolism; a comparison study in diabetic rats. Br J Pharmacol 126(2):467–477

    CAS  PubMed  Google Scholar 

  61. Posner BI, Faure R, Burgess JW, Bevan AP, Lachance D, Zhang-Sun G, Fantus IG, Ng JB, Hall DA, Lum BS et al (1994) Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J Biol Chem 269(6):4596–4604

    CAS  PubMed  Google Scholar 

  62. Bevan AP, Drake PG, Yale JF, Shaver A, Posner BI (1995) Peroxovanadium compounds: biological actions and mechanism of insulin-mimesis. Mol Cell Biochem 153(1–2):49–58

    CAS  PubMed  Google Scholar 

  63. Gupta D, Raju J, Baquer NZ (1999) Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: effect of antidiabetic compounds. Indian J Exp Biol 37(2):196–199

    CAS  PubMed  Google Scholar 

  64. Mooney RA, Bordwell KL, Luhowskyj S, Casnellie JE (1989) The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation. Endocrinology 124(1):422–429

    CAS  PubMed  Google Scholar 

  65. Strout HV, Vicario PP, Saperstein R, Slater EE (1989) The insulin-mimetic effect of vanadate is not correlated with insulin receptor tyrosine kinase activity nor phosphorylation in mouse diaphragm in vivo. Endocrinology 124(4):1918–1924

    CAS  PubMed  Google Scholar 

  66. Fantus IG, Ahmad F, Deragon G (1994) Vanadate augments insulin-stimulated insulin receptor Kinase activity and prolongs insulin action in rat adipocytes. Evidence for transduction of amplitude of signaling into duration of response. Diabetes 43(3):375–383

    CAS  PubMed  Google Scholar 

  67. D’Onofrio F, Le MQ, Chiasson JL, Srivastava AK (1994) Activation of mitogen activated protein (MAP) kinases by vanadate is independent of insulin receptor autophosphorylation. FEBS Lett 340(3):269–275

    PubMed  Google Scholar 

  68. Shisheva A, Shechter Y (1992) Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes. Biochemistry 31(34):8059–8063

    CAS  PubMed  Google Scholar 

  69. Ui M, Okada T, Hazeki K, Hazeki O (1995) Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide 3-kinase. Trends Biochem Sci 20(8):303–307

    CAS  PubMed  Google Scholar 

  70. Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P (1994) The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303(pt 1):21–26

    CAS  PubMed  Google Scholar 

  71. Elberg G, He Z, Li J, Sekar N, Shechter Y (1997) Vanadate activates membranous nonreceptor protein tyrosine kinase in rat adipocytes. Diabetes 46(11):1684–1690

    CAS  PubMed  Google Scholar 

  72. Shisheva A, Shechter Y (1993) Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes. J Biol Chem 268(9):6463–6469

    CAS  PubMed  Google Scholar 

  73. Nielsen F, Uthus E (1990) The essentiality and metabolism of vanadium. In: Chasteen ND (ed) Vanadium in biological systems. Kluwer, Dordrecht, pp 51–62

    Google Scholar 

  74. Nielsen FH (1998) The nutritional essentiality and physiological metabolism of vanadium in higher animals. In: Vanadium compounds, American Chemical Society, Washington, pp 297–307

  75. Heyliger CE, Tahiliani AG, McNeill JH (1985) Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science 227(4693):1474–1477

    CAS  PubMed  Google Scholar 

  76. Becker DJ, Ongemba LN, Henquin JC (1994) Comparison of the effects of various vanadium salts on glucose homeostasis in streptozotocin-diabetic rats. Eur J Pharmacol 260(2–3):169–175

    CAS  PubMed  Google Scholar 

  77. Pederson RA, Ramanadham S, Buchan AM, McNeill JH (1989) Long-term effects of vanadyl treatment on streptozocin-induced diabetes in rats. Diabetes 38(11):1390–1395

    CAS  PubMed  Google Scholar 

  78. Clark TA, Heyliger CE, Kopilas M, Edel AL, Junaid A, Aguilar F, Smyth DD, Thliveris JA, Merchant ME, Kim HK, Pierce GN (2012) A tea/vanadate decoction delivered orally over 14 months to diabetic rats induces long-term glycemic stability without organ toxicity. Metabolism 61(5):742–753

    CAS  PubMed  Google Scholar 

  79. Fantu IG, Deragon G, Lai R, Tang S (1996) The insulin-mimetic agent vanadate promotes receptor endocytosis and inhibits intracellular ligand-receptor degradation by a mechanism distinct from the lysosomotropic agents. Diabetes 45(8):1084–1093

    Google Scholar 

  80. Pugazhenthi S, Hussain A, Yu B, Brownsey RW, Angel FJ, Khandelwal RL (1995) Vanadate induces normolipidemia and a reduction in the levels of hepatic lipogenic enzymes in obese Zudker Rat. Mol Cell Biochem 153(1–2):211–215

    CAS  PubMed  Google Scholar 

  81. Brichard SM, Ongemba LN, Kolanowski J, Henquin JC (1991) The influence of vanadate on insulin counter-regulatory hormones in obese fa/fa rats. J Endocrinol 131(2):185–191

    CAS  PubMed  Google Scholar 

  82. Fantus IG, Tsiani E (1998) Multifunctional actions of vanadium compounds on insulin signaling pathways: evidence for preferential enhancement of metabolic versus mitogenic effects. Mol Cell Biochem 182(1–2):109–119

    CAS  PubMed  Google Scholar 

  83. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR (1995) In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem 153(1–2):217–231

    CAS  PubMed  Google Scholar 

  84. Orvig C, Thompson KH, Battell M, McNeill JH (1995) Vanadium compounds as insulin mimics. Met Ions Biol Syst 31:575–594

    CAS  PubMed  Google Scholar 

  85. Strout HV, Vicario PP, Biswas C, Saperstein R, Brady EJ, Pilch PF, Berger J (1990) Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter in skeletal muscle. Endocrinology 126(5):2728–2732

    CAS  PubMed  Google Scholar 

  86. Kopp SJ, Daar J, Paulson DJ, Romano FD, Laddaga R (1997) Effects of oral vanadyl treatment on diabetes-induced alterations in the heart GLUT-4 transporter. J Mol Cell Cardiol 29(9):2355–2362

    CAS  PubMed  Google Scholar 

  87. Li SH, McNeill JH (2001) In vivo effects of vanadium on GLUT4 translocation in cardiac tissue of STZ-diabetic rats. Mol Cell Biochem 217(1–2):121–129

    CAS  PubMed  Google Scholar 

  88. Hajduch E, Karakhshan F, Hundal HS (1998) Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes. Diabetologia 41(7):821–828

    CAS  PubMed  Google Scholar 

  89. Ding W, Hasegawa T, Hosaka H, Peng D, Takahashi K, Sedo Y (2001) Effect of long-term treatment with vanadate in drinking water on KK mice with genetic non-insulin-dependent diabetes mellitus. Biol Trace Elem Res 80(2):159–174

    CAS  PubMed  Google Scholar 

  90. Gupta D, Raju J, Prakash J, Baquer NZ (1999) Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate. Diabetes Res Clin Pract 46(1):1–7

    CAS  PubMed  Google Scholar 

  91. Sekar N, Grovindasamy S (1991) Effects of vanadate on plasma lipoprotein profiles in experimental diabetic rats. Biochem Int 23(5):935–940

    CAS  PubMed  Google Scholar 

  92. Seranno Rios M (2001) Epidemiology of cardiovascular disease in type 2 diabetes. Int J Clin Pract Suppl 121:4–7

    Google Scholar 

  93. Janka HU (1996) Increased cardiovascular morbidity and mortality in diabetes mellitus: identification of the high risk patient. Diabetes Res Clin Pract 30(Suppl):85–88

    PubMed  Google Scholar 

  94. Clark TA, Pierce GN (2000) Cardiovascular complications of non-insulin-dependent diabetes: the JCR:LA-cp rat. J Pharmacol Toxicol Methods 43:1–10

    CAS  PubMed  Google Scholar 

  95. Pierce GN, Russell JC (1997) Regulation of intracellular Ca2+ in the heart during diabetes. Cardiovasc Res 34:41–47

    CAS  PubMed  Google Scholar 

  96. Pierce GN, Russell JC, Maddaford TG (1997) Cardiovascular dysfunction in insulin-dependent and non-insulin dependent diabetic animals. Can J Physiol Pharmacol 75:343–350

    CAS  PubMed  Google Scholar 

  97. Clark TA, Maddaford TG, Tappia PS, Heyliger CE, Ganguly PK, Pierce GN (2010) Restoration of cardiomyocyte function in streptozotocin-induced diabetic rats after treatment with vanadate in a tea decoction. Curr Pharm Biotechnol 11:906–910

    CAS  PubMed  Google Scholar 

  98. Tappia PS, Maddaford TG, Hurtado C, Dibrov E, Austria JA, Sahi N, Panagia V, Pierce GN (2004) Defective phosphatidic acid-phospholipase C signaling in diabetic cardiomyopathy. Biochem Biophys Res Commun 316:280–289

    CAS  PubMed  Google Scholar 

  99. Ozcelikay AT, Yidizoglu-Ari N, Ozuari A, Ozturk Y, Altan VM (1993) The effect of vanadate on alloxan-diabetic rat atria. Diabetes Res Clin Pract 19(3):189–194

    CAS  PubMed  Google Scholar 

  100. Matsubara T, Musat-Marcu S, Misra HP, Dhalla NS (1995) Protective effect of vanadate on oxyradical-induced changes in isolated perfused heart. Mol Cell Biochem 153(1–2):79–85

    CAS  PubMed  Google Scholar 

  101. Sekar N, Kanthasamy A, William S, Balasubramaniyan N, Govindasamy S (1990) Antioxidant effect of vanadate on experimental diabetic rats. Acta Diabetol Lat 27(4):285–293

    CAS  PubMed  Google Scholar 

  102. Levy E, Bendayan M (1991) Lipoprotein lipase in experimental diabetic rats: beneficial effect of vanadate treatment. Diabete Metab 17(1):44–48

    CAS  PubMed  Google Scholar 

  103. Hopfner RL, Misurski D, Wilson TW, McNeill JR, Gopalakrishnan V (1998) Insulin and vanadate restore decreased plasma endothelin concentrations and exaggerated vascular responses to normal in the streptozotocin diabetic rat. Diabetologia 41(10):1233–1240

    CAS  PubMed  Google Scholar 

  104. Clark TA, Edel AL, Heyliger CE, Pierce GN (2004) Effective control of glycemic status and toxicity in Zucker Diabetic Fatty rats with an orally administered vanadate compound. Can J Physiol Pharmacol 82:888–894

    CAS  PubMed  Google Scholar 

  105. Clark TA, Heyliger CE, Goel DP, Pierce GN (2004) The use of tea as a non-toxic modality to deliver vanadate to streptozotocin-induced diabetic rats. Metabolism 53:1145–1151

    CAS  PubMed  Google Scholar 

  106. Srivastava AK (2000) Anti-diabetic and toxic effects of vanadium compounds. Mol Cell Biochem 206(1–2):177–182

    CAS  PubMed  Google Scholar 

  107. Domingo JL (1996) Vanadium: a review of the reproductive and developmental toxicity. Reprod Toxicol 10(3):175–182

    CAS  PubMed  Google Scholar 

  108. Gil J, Miralpeix M, Carreras J, Bartrons R (1987) Insulin like effects of vanadate on glucokinase activity and fructose-2,6-bisphosphate levels in the liver of diabetic rats. J Biol Chem 262:6658–6662

    Google Scholar 

  109. Brichard SM, Okitolonda W, Henquin JC (1998) Long-term improvement of glucose homeostasis by vanadate treatment in diabetic rats. Endocrinology 123:2048–2053

    Google Scholar 

  110. Blondel O, Bailbe D, Portha B (1989) In vivo insulin resistance in streptozotocin diabetic rats: evidence for reversal following oral vanadate treatment. Diabetologia 32:185–190

    CAS  PubMed  Google Scholar 

  111. Ramanadham S, Mongold JJ, Brownsey RW, Cros GH, McNeill JH (1989) Oral vanadyl sulphate in treatment of diabetes mellitus in rats. Am J Physiol 257:H904–H911

    CAS  PubMed  Google Scholar 

  112. Sakurai H, Tsuchiya K, Nakatsuka M, Sofue M, Kawada J (1990) Insulin-like effects of vanadyl ion in streptozotocin induced diabetic rats. J Endocrinol 126:451–459

    CAS  PubMed  Google Scholar 

  113. Dai S, Thompson KH, Vera E, McNeill JH (1994) Toxicity studies on one-year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulphate. Pharmacol Toxicol 75(5):265–273

    CAS  PubMed  Google Scholar 

  114. Domingo JL, Gomez M, Sanchez DJ, Llobet JM, Keen CL (1994) Relationship between reduction in food intake and amelioration of hyperglycemia by oral vanadate in STZ-induced diabetic rats. Diabetes 43(10):1267, 1269–1270

    Google Scholar 

  115. Ganguli S, Reuland DJ, Franklin LA, Tucker M (1994) Effect of vanadate on reproductive efficiency in normal and streptozotocin-treated diabetic rats. Metabolism 43(11):1384–1388

    CAS  PubMed  Google Scholar 

  116. Ganguli S, Reuland DJ, Franklin LA, Deakins DD, Johnston WJ, Pasha A (1994) Effects of maternal vanadate treatment of fetal development. Life Sci 55(16):1267–1276

    CAS  PubMed  Google Scholar 

  117. Mongold JJ, Cros HG, Vian L, Tep A, Ramanadham S, Siou G, Diaz J, McNeill JH, Serrano JJ (1990) Toxicological aspects of vanadyl sulphate on diabetic rats: effects on vanadium levels and pancreatic B-cell morphology. Pharmacol Toxicol 67(3):192–198

    CAS  PubMed  Google Scholar 

  118. Edel AL, Kopilas M, Clark TA, Aguilar F, Ganguly PK, Heyliger CE, Pierce GN (2006) Short-term bioaccumulation of vanadium when ingested with a tea decoction in streptozotocin-induced diabetic rats. Metabolism 55(2):263–270

    CAS  PubMed  Google Scholar 

  119. Pugazhenthi S, Mantha SV, Khandelwal RL (1990) Decrease of liver protein kinase C in streptozotocin-induced diabetic rats and restoration by vanadate treatment. Biochem Int 21(4):651–657

    CAS  PubMed  Google Scholar 

  120. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR (1995) Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 80:3311–3320

    CAS  PubMed  Google Scholar 

  121. Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rossetti L (1995) Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 95:2501–2509

    CAS  PubMed Central  PubMed  Google Scholar 

  122. Boden G, Chen Z, Ruiz J, Van Rossum GDV, Turco S (1996) Effects of vanadyl sulfate on carbohydrate and lipid metabolism inpatients with non-insulin-dependent diabetes mellitus. Metabolism 45:1130–1135

    CAS  PubMed  Google Scholar 

  123. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC (1998) Trends in alternative medicine use in the United States, 1990–1997. JAMA 280:1569–1575

    CAS  PubMed  Google Scholar 

  124. Manya K, Champion B, Dunning T (2012) The use of complementary and alternative medicine among people living with diabetes in Sydney. BMC Complement Altern Med 12:2. doi:10.1186/1472-6882-12-2

    PubMed Central  PubMed  Google Scholar 

  125. Xie W, Zhao Y, Gu D, Du L, Cai G, Zhang Y (2011) Scorpion in combination with gypsum: novel antidiabetic activities in streptozotocin-induced diabetic mice by up-regulating pancreatic PPARy and PDX-1 Expressions. Evid Based Complement Alternat Med 2011:683561

    PubMed Central  PubMed  Google Scholar 

  126. El-Sayed MI (2011) Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternate therapy. J Ethnopharmacol 137(1):643–651

    PubMed  Google Scholar 

  127. Xie W, Zhao Y, Zhang Y (2011) Traditional Chinese medicines in treatment of patients with type 2 diabetes mellitus. Evid Based Complement Alternat Med 2011:726723

    PubMed Central  PubMed  Google Scholar 

  128. Tam TW, Liu R, Arnason JT, Krantis A, Staines WA, Haddad PS, Foster BC (2011) Cree antidiabetic plant extracts display mechanism-based inactivation of CYP3A4. Can J Physiol Pharmacol 89(1):13–23

    CAS  PubMed  Google Scholar 

  129. Ogbera AO, Dada O, Adeyeye F, Jewo PL (2010) Complementary and alternative medicine use in diabetes mellitus. West Afr J Med 29(3):158–162

    CAS  PubMed  Google Scholar 

  130. Prasad K (2001) Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. J Lab Clin Med 138(1):32–39

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by a grant from the Heart and Stroke Foundation of Canada and through indirect support from St Boniface Hospital Foundation.

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Authors and Affiliations

  1. The Canadian Centre for Agri-food Research in Health and Medicine, St. Boniface Hospital, 351 Tache Avenue, Winnipeg, MB, R2H 2A6, Canada

    Justin F. Deniset & Grant N. Pierce

  2. Department of Physiology, University of Manitoba, Winnipeg, MB, Canada

    Justin F. Deniset & Grant N. Pierce

  3. Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada

    Tod A. Clark

  4. School of Veterinary Medicine, Ross University, Basseterre, St Kitts, West Indies

    Clayton E. Heyliger

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  1. Tod A. Clark
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  2. Justin F. Deniset
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  3. Clayton E. Heyliger
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  4. Grant N. Pierce
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Correspondence to Grant N. Pierce.

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Clark, T.A., Deniset, J.F., Heyliger, C.E. et al. Alternative therapies for diabetes and its cardiac complications: role of vanadium. Heart Fail Rev 19, 123–132 (2014). https://doi.org/10.1007/s10741-013-9380-0

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  • DOI: https://doi.org/10.1007/s10741-013-9380-0

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