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The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly

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Summary

Mutations in the gene coding for the ABC transporter, ABCC6, in humans cause Pseudoxanthoma elasticum, which is characterized by the deposition of aberrant elastic fibers. To investigate whether the presence of ABCC6 in tissues synthesizing elastin is required for elastin deposition and elastic fiber assembly, we have compared the steady-state levels and tissue distribution of Abcc6 and tropoelastin mRNAs during mouse embryogenesis. Whereas tropoelastin mRNA levels rose during embryogenesis and were the highest in neonatal mice, Abcc6 mRNA levels remained constantly low throughout embryogenesis. In some tissues, both Abcc6 and tropoelastin mRNA were detected. However, Abcc6 mRNA and protein were not detected in neonatal aorta and arteries, which produce large amounts of elastin indicating that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly.

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Author notes

  1. Konstanze Beck

    Present address: Centre for Vascular Research, School of Medical Sciences, Faculty of Medicine, University of New South Wales, UNSW, Sydney, NSW, 2052, Australia

Authors and Affiliations

  1. Cardiovascular Research Center, John A. Burns School of Medicine, University of Hawai’i, Honolulu, Hawaii, USA

    Konstanze Beck, Kaohimanu Dang & Charles D. Boyd

Authors
  1. Konstanze Beck
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  2. Kaohimanu Dang
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  3. Charles D. Boyd
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Correspondence to Konstanze Beck.

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Beck, K., Dang, K. & Boyd, C.D. The tissue distribution of murine Abcc6 (Mrp6) during embryogenesis indicates that the presence of Abcc6 in elastic tissues is not required for elastic fiber assembly. J Mol Hist 36, 167–170 (2005). https://doi.org/10.1007/s10735-005-0820-6

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  • DOI: https://doi.org/10.1007/s10735-005-0820-6

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