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Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan

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Abstract

In this study, we synthesized a novel water-soluble low molecular chitosan (LMC) derivative through Vilsmeier reaction and reductive amination reaction. The derivative was characterized by UV-visible spectroscopy, 1H NMR, FTIR and SEM techniques. The results showed that the derivative effectively reduced the cell viability rate, inhibited cell metastasis, induced cell apoptosis and dissipated mitochondrial membrane potential (ΔΨm). Moreover, the antitumor activity was strengthened with the increase of the degree of substitution of tanshinone I (TanI). These findings provided important support for developing new water-soluble antitumor agent and expand the scope of application of LMC.

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Acknowledgments

This project was supported by the National Natural Science Foundation of China (NSFC) (Grant31570799) and Program for New Century Excellent Talents in University (NCET-13-0480).

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Authors and Affiliations

  1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling, Shaanxi, 712100, China

    Dongdong Wang,  DanXu, Yuelin Sun, Yuanyuan Wu & Jinyou Duan

  2. Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Lili Ma

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  1. Dongdong Wang
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  2. DanXu
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  3. Yuelin Sun
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  4. Yuanyuan Wu
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  5. Lili Ma
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Correspondence to Lili Ma or Jinyou Duan.

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The manuscript did not contain animal experiments, and all other experiments were compliance with ethical standards.

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Wang, D., DanXu, Sun, Y. et al. Synthesis, characterization and anticancer activity of tanshinone I grafted low molecular chitosan. Glycoconj J 34, 3–12 (2017). https://doi.org/10.1007/s10719-016-9712-0

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  • DOI: https://doi.org/10.1007/s10719-016-9712-0

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