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Anticancer Effects of Chitooligosaccharides

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Chitooligosaccharides

Abstract

Investigation into the novel biocompatible substances with anticancer activity has adopted a new route for the development of chemotherapeutic substances, due to their reduced toxicity on normal cells. Chitooligosaccharides are the biopolymers derived from Chitosan. Due to poor water solubility issues, chitin and chitosan have fewer actions against malignant cells. Water-soluble derivatives of chitin and chitosan were developed using physical, chemical, and enzymatic methods to generate chitooligosaccharides (COS) with outperforming biological activity compared to the naive polymer. Because of the COS's reduced molecular weight with the degree of polarization, solubility, and certain physicochemical properties, it is widely used in a variety of sectors for the product development. COS can easily permeate the cancer cells. COS derivatives greatly limit the formation of new blood vessels in tumors, thereby blocking tumor progression and metastasis. It has the ability to decrease free radicals in normal cells, which are implicated in cellular damage. In this book chapter, we discuss how chitooligosaccharides and their derivatives affect cancer cells, their apoptotic and antiangiogenic activities, their utilization in drug delivery, and designing novel therapeutic approaches for cancer using COS.

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  1. Yenepoya Research Centre, Yenepoya (Deemed To Be University), Deralakatte, Mangalore, Karnataka, 575018, India

    S. R. Pavan, Jayachandran Venkatesan & Ashwini Prabhu

  2. Department of Marine Science and Technology, Hanyang University, Hanyang, South Korea

    Se-Kwon Kim

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  1. S. R. Pavan
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  2. Jayachandran Venkatesan
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  3. Se-Kwon Kim
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  4. Ashwini Prabhu
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  1. Department of Marine Science and Convergence Engineering, College of Science and Technology, Hanyang University ERICA, Seoul, Korea (Republic of)

    Se-Kwon Kim

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Pavan, S.R., Venkatesan, J., Kim, SK., Prabhu, A. (2022). Anticancer Effects of Chitooligosaccharides. In: Kim, SK. (eds) Chitooligosaccharides. Springer, Cham. https://doi.org/10.1007/978-3-030-92806-3_8

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