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Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis

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An Erratum to this article was published on 06 February 2013

Abstract

To characterize the frequency of germline mutations associated with Lynch syndrome and review the potential expanded differential diagnoses in very early onset colorectal cancer (CRC) cases without apparent polyposis. Retrospectively reviewed medical records of 96 probands with CRC diagnosed prior to age 36 from three cancer centers. Determined the frequency of germline mutations in probands meeting different clinical criteria used to identify Lynch syndrome. Three of 46 (6.5%) single case indicators (probands without additional personal or family history suspicious for Lynch syndrome) were identified to carry a deleterious or suspected deleterious mismatch repair (MMR) mutation compared with 10 of 19 (52.6%) in the cases meeting at least one additional revised Bethesda guideline, and 11 of 15 (73.3%) in the cases meeting Amsterdam criteria. Two families without MMR mutations were documented to have a germline APC or TP53 mutation after additional clinical features were identified. Our results suggest that single cases of CRC (those without additional personal or family history suspicious of Lynch syndrome) diagnosed prior to age 36 infrequently have identifiable MMR mutations, especially when compared to cases meeting additional criteria. Careful attention to evolving or additional clinical features is warranted and may lead to an alternate genetic diagnosis in families with early onset CRC.

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Abbreviations

AC:

Amsterdam criteria

AFAP:

Attenuated familial adenomatous polyposis

CRC:

Colorectal cancer

IHC:

Immunohistochemistry

MAP:

MYH associated polyposis

MMR:

Mismatch repair

MSI:

Microsatellite instability

UPDB:

Utah Population Database

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Acknowledgments

We would like to thank the expert input from Katrina Lowstuter MS, CGC regarding this manuscript. This research was supported in part by a General Clinical Research Center grant from NIH (M01 RR00043) and by the National Cancer Institute, Grant No. R25 CA85771.

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Authors and Affiliations

  1. Cancer Screening & Prevention Program, City of Hope Cancer Center, Duarte, CA, USA

    Kory W. Jasperson & Jeffrey N. Weitzel

  2. Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Room 4158, Salt Lake City, UT, 84112, USA

    Kory W. Jasperson, Angela L. Schwab, Deborah W. Neklason & Randall W. Burt

  3. Department of Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Thuy M. Vu & Miguel A. Rodriguez-Bigas

Authors
  1. Kory W. Jasperson
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  2. Thuy M. Vu
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  3. Angela L. Schwab
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  4. Deborah W. Neklason
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  5. Miguel A. Rodriguez-Bigas
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  6. Randall W. Burt
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  7. Jeffrey N. Weitzel
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Correspondence to Kory W. Jasperson.

Additional information

An erratum to this article can be found online at http://dx.doi.org/10.1007/s10689-013-9603-5.

Appendix

Appendix

See Tables 5 and 6.

Table 5 Revised Bethesda guidelines
Full size table
Table 6 Clinicalpathological characteristics and demographics of probands
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Jasperson, K.W., Vu, T.M., Schwab, A.L. et al. Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis. Familial Cancer 9, 99–107 (2010). https://doi.org/10.1007/s10689-009-9290-4

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  • DOI: https://doi.org/10.1007/s10689-009-9290-4

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