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Triclosan in over the counter medicines of South China

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Abstract

Triclosan (TCS) is an endocrine disruptor which may affect endocrine function, antibiotic resistance, and thyroid hormone homeostasis. As a broad-spectrum antimicrobial agent used in medical and personal care products, TCS was frequently detected in human urine, indicating widespread human exposure to this chemical. Over-the-counter medicines (OTCs) may be a potential source of human exposure to TCS. In this study, 84 OTCs were collected from Guangzhou, South China, including medicines intended for both children and adults. We determined the concentration of TCS in OTCs and the estimated daily intakes (EDIs) of TCS by evaluating OTCs for different age groups of the Chinese population. Our results indicated over half of the evaluated medicines contained TCS and the highest concentration reached 7.825 ng/g, with a median value of 0.017 ng/g. TCS was frequently found in adult medicines (detected in 85% of samples), and the concentrations were significantly higher than those in children’s medicines. TCS in OTCs may come from packaging materials, cultivated soils, or production process (Chinese patent medicines). The EDIs of TCS (estimated with 95th concentration in OTC medicines) were 0.305, 0.191, 0.287, 0.331, and 0.135 and 0.110 ng/kg-bw/day for infants, toddlers, children, teenagers, and adult females and males, respectively. Compared to other potential sources, human exposure to TCS from OTCs was limited in China—much less than TCS exposure through personal care products or indoor dust.

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References

  • Allmyr, M., Adolfsson-Erici, M., McLachlan, M. S., & Sandborgh-Englund, G. (2006). Triclosan in plasma and milk from swedish nursing mothers and their exposure via personal care products. Science of the Total Environment, 372, 87–93.

    Article  CAS  Google Scholar 

  • Ao, J., Yuan, T., Ma, Y., Gao, L., Ni, N., & Li, D. (2017). Identification, characteristics and human exposure assessments of triclosan, bisphenol-a, and four commonly used organic uv filters in indoor dust collected from shanghai, China. Chemosphere, 184, 575–583.

    Article  CAS  Google Scholar 

  • Armstrong, D. L., Lozano, N., Rice, C. P., Ramirez, M., & Torrents, A. (2018). Degradation of triclosan and triclocarban and formation of transformation products in activated sludge using benchtop bioreactors. Environmental Research, 161, 17–25.

    Article  CAS  Google Scholar 

  • Azzouz, A., Rascón, A. J., & Ballesteros, E. (2016). Simultaneous determination of parabens, alkylphenols, phenylphenols, bisphenol a and triclosan in human urine, blood and breast milk by continuous solid-phase extraction and gas chromatography–mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 119, 16–26.

    Article  CAS  Google Scholar 

  • Bhargava, H., & Leonard, P. A. (1996). Triclosan: applications and safety. American Journal of Infection Control, 24, 209–218.

    Article  CAS  Google Scholar 

  • Canosa, P., Rodriguez, I., Rubi, E., & Cela, R. (2007). Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry. Analytical Chemistry, 79, 1675–1681.

    Article  CAS  Google Scholar 

  • China Nonprescription Medicines Association. 2018. China ranked the second in phamaceutical market in the world, with only 6% innovative drugs. Available: http://cnma.ittn.com.cn/home/list/content?article_id=2248&id=18 [accessed June 10 2018].

  • Chung, D., Papadakis, S. E., & Yam, K. L. (2003). Evaluation of a polymer coating containing triclosan as the antimicrobial layer for packaging materials. International Journal of Food Science and Technology, 38, 165–169.

    Article  CAS  Google Scholar 

  • Dann, A. B., & Hontela, A. (2011). Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of Applied Toxicology, 31, 285–311.

    Article  CAS  Google Scholar 

  • Durán-Álvarez, J., Prado, B., González, D., Sánchez, Y., & Jiménez-Cisneros, B. (2015). Environmental fate of naproxen, carbamazepine and triclosan in wastewater, surface water and wastewater irrigated soil—results of laboratory scale experiments. Science of the Total Environment, 538, 350–362.

    Article  Google Scholar 

  • Fan, X., Kubwabo, C., Rasmussen, P., & Jones-Otazo, H. (2010). Simultaneous quantitation of parabens, triclosan, and methyl triclosan in indoor house dust using solid phase extraction and gas chromatography-mass spectrometry. Journal of Environmental Monitoring, 12, 1891–1897.

    Article  CAS  Google Scholar 

  • Goodman M, Naiman DQ, LaKind JS. 2018. Systematic review of the literature on triclosan and health outcomes in humans. Critical Reviews in Toxicology 48, 1–15.

  • Guo, Y., & Kannan, K. (2013). A survey of phthalates and parabens in personal care products from the United States and its implications for human exposure. Environmental Science and Technology, 47, 14442–14449.

    Article  CAS  Google Scholar 

  • Li, X., Ying, G.-G., Su, H.-C., Yang, X.-B., & Wang, L. (2010). Simultaneous determination and assessment of 4-nonylphenol, bisphenol a and triclosan in tap water, bottled water and baby bottles. Environment International, 36, 557–562.

    Article  CAS  Google Scholar 

  • Li, X., Ying, G.-G., Zhao, J.-L., Chen, Z.-F., Lai, H.-J., & Su, H.-C. (2013). 4-nonylphenol, bisphenol-a and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. Environment International, 52, 81–86.

    Article  CAS  Google Scholar 

  • Liao, C., & Kannan, K. (2014). A survey of alkylphenols, bisphenols, and triclosan in personal care products from China and the United States. Archives of Environmental Contamination and Toxicology, 67, 50–59.

    Article  CAS  Google Scholar 

  • Liao, C., Liu, F., Guo, Y., Moon, H.-B., Nakata, H., Wu, Q., et al. (2012). Occurrence of eight bisphenol analogues in indoor dust from the United States and several asian countries: implications for human exposure. Environmental Science and Technology, 46, 9138–9145.

    Article  CAS  Google Scholar 

  • Liu, T., & Wu, D. (2012). High-performance liquid chromatographic determination of triclosan and triclocarban in cosmetic products. International Journal of Cosmetic Science, 34, 489–494.

    Article  CAS  Google Scholar 

  • Lu, J., Mao, H., Li, H., Wang, Q., & Yang, Z. (2017). Occurrence of and human exposure to parabens, benzophenones, benzotriazoles, triclosan and triclocarban in outdoor swimming pool water in Changsha, China. Science of the Total Environment, 605, 1064–1069.

    Article  Google Scholar 

  • Montaseri, H., & Forbes, P. B. (2016). A review of monitoring methods for triclosan and its occurrence in aquatic environments. TrAC Trends in Analytical Chemistry, 85, 221–231.

    Article  CAS  Google Scholar 

  • National Health and Health Commission of People's Republic of China. 2015. Report on nutrition and chronic diseases in china (2015). Available: http://www.nhfpc.gov.cn/jkj/s5879/201506/4505528e65f3460fb88685081ff158a2.shtml [accessed June 10 2018].

  • National Industrial Chemicals Notification and Assessment Scheme. 2001. Priority existing chemical assessment report no. 30: Triclosan. Available: https://www.nicnas.gov.au/search?query=TRICLOSAN&collection=nicnas-meta [accessed June 10 2018].

  • Olaniyan, L., Mkwetshana, N., & Okoh, A. (2016). Triclosan in water, implications for human and environmental health. Springerplus, 5, 1639.

    Article  CAS  Google Scholar 

  • Prosser, R. S., Lissemore, L., Topp, E., & Sibley, P. K. (2014). Bioaccumulation of triclosan and triclocarban in plants grown in soils amended with municipal dewatered biosolids. Environmental Toxicology and Chemistry, 33, 975–984.

    Article  CAS  Google Scholar 

  • Pusceddu, F., Choueri, R., Pereira, C., Cortez, F., Santos, D., Moreno, B., et al. (2018). Environmental risk assessment of triclosan and ibuprofen in marine sediments using individual and sub-individual endpoints. Environmental Pollution, 232, 274–283.

    Article  CAS  Google Scholar 

  • Shapiro, G. D., Arbuckle, T. E., Ashley-Martin, J., Fraser, W. D., Fisher, M., Bouchard, M. F., et al. (2018). Associations between maternal triclosan concentrations in early pregnancy and gestational diabetes mellitus, impaired glucose tolerance, gestational weight gain and fetal markers of metabolic function. Environmental Research, 161, 554–561.

    Article  CAS  Google Scholar 

  • Soares, N., Moreira, F., Fialho, T., & Melo, N. (2012). Triclosan-based antibacterial paper reinforced with nano-montmorillonite: a model nanocomposite for the development of new active packaging. Polymers for Advanced Technologies, 23, 901–908.

    Article  CAS  Google Scholar 

  • Witorsch, R. J. (2014). Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products. Critical Reviews in Toxicology, 44, 535–555.

    Article  CAS  Google Scholar 

  • Zhang, Q. Q., Zhao, J. L., Liu, Y. S., Li, B. G., & Ying, G. G. (2013). Multimedia modeling of the fate of triclosan and triclocarban in the dongjiang river basin, South China and comparison with field data. Environmental Science-Processes & Impacts, 15, 2142–2152.

    Article  CAS  Google Scholar 

  • Zhao, J. L., Ying, G. G., Liu, Y. S., Chen, F., Yang, J. F., & Wang, L. (2010). Occurrence and risks of triclosan and triclocarban in the pearl river system, South China: from source to the receiving environment. Journal of Hazardous Materials, 179, 215–222.

    Article  CAS  Google Scholar 

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Funding

The present study was financially supported by the National Natural Science Funds for Distinguished Young Scholar of Guangdong Province, China (No. 2016A030306015), the National Natural Science Foundation of China (No. 21577050), and the Guangdong Innovative and Entrepreneurial Research Team Program, China (No. 2016ZT06N258).

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  1. School of Environment, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, 510632, China

    Chong-Jing Gao, Lu-Lu Jia & Ying Guo

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  1. Chong-Jing Gao
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  2. Lu-Lu Jia
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  3. Ying Guo
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Correspondence to Ying Guo.

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Gao, CJ., Jia, LL. & Guo, Y. Triclosan in over the counter medicines of South China. Environ Monit Assess 190, 728 (2018). https://doi.org/10.1007/s10661-018-7111-7

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