Abstract
Phyllanthus niruri is a plant that is used to prevent calcium oxalate crystallisation and to block the stone formation in urolithiasis. Contaminants in the environment can be readily taken up by medicinal plants due to their ability to absorb chemicals into their tissues. If contaminated plants are ingested, they have the potential to negatively affect human and environmental health. The aim of this study was to assess contamination in the soil and the medicinal plant P. niruri by cadmium (Cd) in ceramic industrial areas of Monte Carmelo, Brazil. Soil samples and plant samples (divided in root, shoot and leaves) were collected from a contaminated monitoring site and from a rural area (which was used as a reference site for comparative purposes). The Cd concentrations of the samples were analysed with an atomic absorption spectrometer. P. niruri was found to be sensitive to soil contamination by Cd that was attributed to ceramic industrial emissions. The results revealed that Cd bioaccumulation in the roots and shoots of P. niruri was associated with a significant increase (p < 0.05) in the concentration of active lignan compounds (phyllanthin and hypophyllanthin) in the leaves. The identification of high concentrations of Cd and active lignan compounds suggests a risk of contamination of the site and the risk of a high dose of Cd to people exposed at the site.
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References
Bruus Pedersen, M., & van Gestel, C. A. (2001). Toxicity of copper to the collembolan Folsomia fimetaria in relation to the age of soil contamination. Ecotoxicology and Environmental Safety, 49, 54–59. https://doi.org/10.1006/eesa.2001.2043.
CONAMA. Conselho Nacional do Meio Ambiente. Ministério do Meio Ambiente Resolução n° 420, de 28 de Dezembro de 2009. Dispõe sobre critérios e valores orientadores de qualidade do solo quanto à presença de substâncias químicas e estabelece diretrizes para o gerenciamento ambiental de áreas contaminadas por essas substâncias em decorrência de atividades antrópicas. In: MMA. Livro das Resoluções do CONAMA. Brasília. Available from: http://www.mma.gov.br/port/conama/res/res09/res42009.pdf
Eweka, A., & Enogieru, A. (2011). Effects of oral administration of Phyllanthus amarus leaf extract on the kidneys of adult Wistar rats—a histological study. African Journal of Traditional, Complementary, and Alternative Medicines, 8, 307–311. https://doi.org/10.4314/ajtcam.v8i3.65294.
Filipic, M., & Hei, T. K. (2004). Mutagenicity of cadmium in mammalian cells: implications of oxidative damage. Mutation Research, 546, 81–91. https://doi.org/10.1016/j.mrfmmm.2003.11.006.
He, K., Sun, S., Hu, Y., Zeng, X., Yu, Z., & Cheng, H. (2017). Comparison of soil heavy metal pollution caused by e-waste recycling activities and traditional industrial operations. Environmental Science and Pollution Research International, 24, 9387–9398. https://doi.org/10.1007/s11356-017-8548-x.
Johri, N., Jacquillet, G., & Unwin, R. (2010). Heavy metal poisoning: the effects of cadmium on the kidney. Biometals, 23, 783–792. https://doi.org/10.1007/s10534-010-9328-y.
Kaur, N., Kaur, V., & Sirhindi, G. (2017). Phytochemistry and pharmacology of Phyllanthus niruri L.: a review. Phytotherapy Research, 31, 980–1004. https://doi.org/10.1002/ptr.5825.
Khan, S., Cao, Q., Zheng, Y. M., Huang, Y. Z., & Zhu, Y. G. (2008). Health risks of heavy metals in contaminated soils and food crops irrigated with wastewater in Beijing, China. Environmental Pollution, 152, 686–692. https://doi.org/10.1016/j.envpol.2007.06.056.
Khan, K., Lu, Y., Khan, H., Ishtiaq, M., Khan, S., Waqas, M., Wei, L., & Wang, T. (2013). Heavy metals in agricultural soils and crops and their health risks in Swat District, northern Pakistan. Food and Chemical Toxicology, 58, 449–458. https://doi.org/10.1016/j.fct.2013.05.014.
Khatoon, S., Rai, V., Rawat, A. K. S., & Mehrotra, S. (2006). Comparative pharmacognostic studies of three Phyllanthus species. Journal of Ethnopharmacology, 104, 79–86. https://doi.org/10.1016/j.jep.2005.08.048.
Kim, J., Song, H., Heo, H. R., Kim, J. W., Kim, H. R., Hong, Y., Yang, S. R., Han, S. S., Lee, S. J., Kim, W. J., & Hong, S. H. (2017). Cadmium-induced ER stress and inflammation are mediated through C/EBP–DDIT3 signalling in human bronchial epithelial cells. Experimental & Molecular Medicine, 49, e372. https://doi.org/10.1038/emm.2017.125.
Krishnamurti, G. V., & Seshadri, T. R. (1946). The bitter principle of Phyllanthus niruri. Proceedings of the Indian Academy Science A, 24, 357–364. https://doi.org/10.1007/BF03171072.
Li, F. S., & Weng, J. K. (2017). Demystifying traditional herbal medicine with modern approach. Nature Plants, 3, 17109. https://doi.org/10.1038/nplants.2017.109.
Lee, N. Y. S., Khoo, W. K. S., Adnan, M. A., Mahalingam, T. P., Fernandez, A. R., & Jeevaratnam, K. (2016). The pharmacological potential of Phyllanthus niruri. The Journal of Pharmacy and Pharmacology, 68, 953–969. https://doi.org/10.1111/jphp.12565.
Liaw, F. Y., Chen, W. L., Kao, T. W., Chang, Y. W., & Huang, C. F. (2017). Exploring the link between cadmium and psoriasis in a nationally representative sample. Scientific Reports, 7, 1723. https://doi.org/10.1038/s41598-017-01827-9.
MERCOSUL. Mercado Comum do Sul. Resolução - RDC n° 42, de 29 de Agosto de 2013 (2013) Dispõe sobre o Regulamento Técnico MERCOSUL sobre Limites Máximos de Contaminantes Inorgânicos em Alimentos. Brasília. Available from: http://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2013/rdc0042_29_08_2013.html
Micali, S., Sighinolfi, M. C., Celia, A., De Stefani, S., Grande, M., Cicero, A. F., & Bianchi, G. (2006). Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. The Journal of Urology, 176, 1020–1022. https://doi.org/10.1016/j.juro.2006.04.010.
Nawab, J., Khan, S., Shah, M. T., Qamar, Z., Din, I., Mahmood, Q., Gul, N., & Huang, Q. (2015). Contamination of soil, medicinal, and fodder plants with lead and cadmium present in mine-affected areas, Northern Pakistan. Environmental Monitoring and Assessment, 187, 605. https://doi.org/10.1007/s10661-015-4807-9.
Petrovska, B. B. (2012). Historical review of medicinal plants’ usage. Pharmacognosy Reviews, 6, 1–5. https://doi.org/10.4103/0973-7847.95849.
Rai, V., Khatoon, S., Bisht, S. S., & Mehrotra, S. (2005). Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. And Thonn. Chemosphere, 61, 1644–1650. https://doi.org/10.1016/j.chemosphere.2005.04.052.
Sarma, H., Deka, S., Deka, H., & Saikia, R. R. (2011). Accumulation of heavy metals in selected medicinal plants. Reviews of Environmental Contamination and Toxicology, 214, 63–86. https://doi.org/10.1007/978-1-4614-0668-6_4.
Stajnko, A., Falnoga, I., Tratnik, J. S., Mazej, D., Jagodic, M., Krsnik, M., Kobal, A. B., Prezelj, M., Kononenko, L., & Horvat, M. (2016). Low cadmium exposure in males and lactating females—estimation of biomarkers. Environmental Research, 152, 109–119. https://doi.org/10.1016/j.envres.2016.09.025.
Tripathi, A. K., Verma, R. K., Gupta, A. K., Gupta, M. M., & Khanuja, S. P. S. (2006). Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. Phytochemical Analysis, 17, 394–397.
Qi, W., Hua, L., & Gao, K. (2014). Chemical constituents from the genus Phyllanthus. Chemistry & Biodiversity, 11, 364–395. https://doi.org/10.1002/cbdv.201200244.
WHO/FAO (2007). Joint FAO/WHO Food Standard Programme Codex Alimentarius Commission 13th Session. Report of the thirty eight session of the codex committee on food hygiene, Houston, United States of America, ALINORM 07/30/13. Available from: ftp://ftp.fao.org/codex/Reports/Alinorm07/al30_13e.pdf.
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This study received financial support from “Conselho Nacional de Desenvolvimento Científico e Tecnológico” (CNPq).
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Santos, V.S.V., Arantes, K.M., Gonçalves, E.L. et al. Contamination of soil and the medicinal plant Phyllanthus niruri Linn. with cadmium in ceramic industrial areas. Environ Monit Assess 190, 303 (2018). https://doi.org/10.1007/s10661-018-6693-4
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DOI: https://doi.org/10.1007/s10661-018-6693-4