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Quantitative determination of dimethyl fumarate in silica gel by solid-phase microextraction/gas chromatography/mass spectrometry and ultrasound-assisted extraction/gas chromatography/mass spectrometry

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Abstract

Dimethyl fumarate (DMF) is a chemical compound which has been added to silica gel bags used for preserving leather products during shipment. DMF has recently been singled out due to its ability to induce a number of medical problems in people which touch products contaminated by it. Its use as a biocide has been recently made illegal in Europe. Two different extraction techniques, namely ultrasound-assisted extraction (UAE) and solid-phase microextraction (SPME), both coupled with gas chromatography/mass spectrometry were applied to the quantitative determination of DMF in silica gel. Linearity of the methods, reproducibility and detection limits were determined. The two methods were applied to the quantification of DMF in thirty-four silica gel samples used as anti-mould agents in different leather products sold in Italy, and the obtained results were statistically compared.

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References

  • Bojko, B., Cudjoe, E., Gomez-Rios, G. A., Gorynski, K., Jiang, R., Reyes-Garces, N., Risticevic, S., Silva, E. A. S., Togunde, O., Vuckovic, D., & Pawliszyn, J. (2012). SPME—quo vadis? Analytica Chimica Acta, 750, 132–151.

    Article  CAS  Google Scholar 

  • Commission Regulation No. 412/2012 of 15 May 2012, Official Journal of the European Union, 16 May 2012, pp. L 128/1-3.

  • Cuadros, R. M., Font, J., Reyes, M., Ollé, L. L., & Marsal, A. (2010). Determination of dimethylfumarate in leather and footwear by solid-phase micro extraction and gas chromatography–mass spectrometry. Journal of the American Leather Chemists Association, 105(12), 395–400.

    CAS  Google Scholar 

  • European Directive, 2009/251/EC, Commission Decision of 17 March 2009, Official Journal of the European Union, 20 March 2009, pp. L 74/32–34.

  • Gennari, O., Montesano, D., Salzano, A., Albrizio, S., & Grumetto, L. (2011). Determination of dimethyl fumarate in desiccant and antimould sachets by reversed-phase liquid chromatography. Biomedical Chromatography, 25(12), 1315–1318.

    Article  CAS  Google Scholar 

  • González-Guzmán, L. A., Goday, J. J., Barja-López, J. M., & Pérez-Varela, L. (2010). Allergic contact dermatitis due to dimethyl fumarate in boots. Actas Dermo-Sifiliográficas (English Edition)., 101(4), 366–367.

    Article  Google Scholar 

  • Kawakami, T., Isama, K., Matsuoka, A., & Nishimura, T. (2011). Determination of dimethyl fumarate and other fumaric and maleic acid diesters in desiccants and consumer products in Japan. Journal of Health Science, 57(3), 236–244.

    Article  CAS  Google Scholar 

  • Lamas, J. P., Sanchez-Prado, L., Garcia-Jares, C., & Llompart, M. (2009a). Determination of dimethyl fumarate in desiccant and mouldproof agents using ultrasound-assisted extraction gas chromatography with electron-capture detection. Journal of Chromatography. A, 1216(30), 5755–5758.

    Article  CAS  Google Scholar 

  • Lamas, J. P., Sanchez-Prado, L., Regueiro, J., Llompart, M., & Garcia-Jares, C. (2009b). Determination of dimethyl fumarate and other potential allergens in desiccant and antimould sachets. Analytical and Bioanalytical Chemistry, 393(8), 2231–2239.

    Article  Google Scholar 

  • Luque de Castro, M. D., & Priego-Capote, F. (2007). Ultrasound assistance to liquid–liquid extraction: a debatable analytical tool. Analytica Chimica Acta, 583(1), 2–9.

    Article  CAS  Google Scholar 

  • Narizzano, R., Risso, F., Venturelli, G., Devia, C., Carlini, E., & Maggiolo, S. (2007). Gas-chromatography-mass spectrometry analysis of dimethyl fumarate in consumer products. Journal of Chromatography. A, 1216(39), 6762–6766.

    Article  Google Scholar 

  • Ouyang, G., Vuckovic, D., & Pawliszyn, J. (2011). Nondestructive sampling of living systems using in vivo solid-phase microextraction. Chemical Reviews, 111(4), 2784–2814.

    Article  CAS  Google Scholar 

  • Rantanen, T. (2008). The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfu marate, a novel potent contact sensitizer. British Journal of Dermatology, 159(1), 218–221.

    Article  CAS  Google Scholar 

  • Stefanelli, P., Barbini, D. A., Girolimetti, S., Santilio, A., & Dommarco, R. (2011). Determination of dimethyl fumarate (DMFu) in silica gel pouches using gas chromatography coupled ion trap mass spectrometry. Journal of Environmental Science and Health B, 46(4), 341–349.

    Article  CAS  Google Scholar 

  • Vuckovic, D., Zhang, X., Cudjoe, E., & Pawliszyn, J. (2010). Solid-phase microextraction in bioanalysis: new devices and directions. Journal of Chromatography. A, 1217, 4041–4060.

    Article  CAS  Google Scholar 

  • Wang, L., Qian, S., Zhang, Y., Chen, S., & Zhang, X. (2012). Determination of dimethyl fumarate in leather: purge-assisted headspace solid-phase microextraction coupled with GC-MS. Journal of the Society of Leather Technologies and Chemists, 96(4), 148–151.

    CAS  Google Scholar 

  • Williams, J. D. L., Coulson, I. H., Susitaival, P., & Winhoven, S. M. (2008). An outbreak of furniture dermatitis in the U.K. British Journal of Dermatology, 159(1), 233–234.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Dipartimento di Chimica “G. Ciamician”, Università degli Studi di Bologna, via Selmi 2, 40126, Bologna, Italy

    Paola Bocchini, Francesca Pinelli, Romina Pozzi, Federica Ghetti & Guido C. Galletti

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  1. Paola Bocchini
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  2. Francesca Pinelli
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  3. Romina Pozzi
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  4. Federica Ghetti
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  5. Guido C. Galletti
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Correspondence to Paola Bocchini.

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Bocchini, P., Pinelli, F., Pozzi, R. et al. Quantitative determination of dimethyl fumarate in silica gel by solid-phase microextraction/gas chromatography/mass spectrometry and ultrasound-assisted extraction/gas chromatography/mass spectrometry. Environ Monit Assess 187, 320 (2015). https://doi.org/10.1007/s10661-015-4567-6

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  • DOI: https://doi.org/10.1007/s10661-015-4567-6

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