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DDT, DDE, and 1-hydroxypyrene levels in children (in blood and urine samples) from Chiapas and Oaxaca, Mexico

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Abstract

The aim of this study was to evaluate the DDT, DDE, and 1-hydroxypyrene exposure levels of children living in communities located in southeastern Mexico. The study communities were Lacanja and Victoria in Chiapas state and Ventanilla in Oaxaca state. Children living in Lacanja had total blood DDT levels (mean ± SD, 29,039.6 ± 11,261.4 ng/g lipid) that were significantly higher than those of children in Victoria (10,220.5 ± 7,893.1 ng/g lipid) and Ventanilla (11,659.7 ± 6,683.7 ng/g lipid). With respect to the 1-hydroxypyrene levels in urine samples, the levels in Lacanja (4.8 ± 4.1 μg/L or 4.5 ± 3.9 μmol/mol creatinine) and Victoria (4.6 ± 3.8 μg/L or 3.9 ± 3.0 μmol/mol Cr) were significantly higher than levels found in Ventanilla (3.6 ± 1.4 μg/L or 2.5 ± 0.5 μmol/mol Cr). In conclusion, our data indicate high levels of exposure in children living in the communities studied in this work. The evidence found in this study could be further used as a trigger to revisit local policies on environmental exposures.

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References

  • ATSDR. (2013). Toxicological profile for polycyclic aromatic hydrocarbons. Agency for toxic substances and diseases registry. Atlanta, GA. USA. http://www.atsdr.cdc.gov/toxprofiles/tp69.pdf. Accessed on 19-04-2013.

  • Domínguez-Cortinas, G., Díaz-Barriga, F., Martínez-Salinas, R. I., Cossío, P., & Pérez-Maldonado, I. N. (2013). Exposure to chemical mixtures in Mexican children: high-risk scenarios. Environmental Science Pollution Research Internacionales, 20(1), 351–357.

    Article  Google Scholar 

  • Direccion General de Epidemiologia Secretaria de Salubridad y Asistencia (DGE SSA). (1996). Boletín de Paludismo y otras enfermedades transmitidas por vector. 6, 2–10.

  • Eskenazi, B., Chevrier, J., Rosas, G. L., Anderson, H. A., Bornman, M. S., Bouwman, H., Chen, A., Cohn, B. A., Jager, C., Henshel, D. S., Leipzig, F., Leipzig, L. S., Lorenz, E. C., Snedeker, S. M., & Stapleton, D. (2009). The Pine River Statement: human health consequences of DDT use. Environmental Health Perspectives, 117, 1359–1367.

    CAS  Google Scholar 

  • Fan, R., Wang, D., Mao, C., Ou, S., Lian, Z., Huang, S., Lin, Q., Ding, R., She, J. (2012). Preliminary study of children’s exposure to PAHs and its association with 8-hydroxy-2'-deoxyguanosine in Guangzhou, China. Environment International. 2012;42:53–58.

    Google Scholar 

  • Franco, S. S., Nardocci, A. C., & Günther, W. M. (2008). PAH biomarkers for human health risk assessment: a review of the state-of-the-art. Cadernos de Saúde Pública, 24, s569–s580.

    Article  Google Scholar 

  • Freire, C., Abril, A., Fernández, M. F., Ramos, R., Estarlich, M., Manrique, A., Aguirre, A., Ibarluzea, J., & Olea, N. (2009). Urinary 1-hydroxypyrene and PAH exposure in 4-year-old Spanish children. Science of the Total Environment, 407, 1562–1569.

    Article  CAS  Google Scholar 

  • Hu, S. W., Chan, Y. J., Hsu, H. T., Wu, K. Y., Changchien, G. P., Shie, R. H., & Chan, C. C. (2011). Urinary levels of 1-hydroxypyrene in children residing near a coal-fired power plant. Environmental Research, 111, 1185–1191.

    Article  CAS  Google Scholar 

  • Jacob, J., & Seidel, A. (2002). Biomonitoring of polycyclic aromatic hydrocarbons in human urine. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 778, 31–47.

    Article  CAS  Google Scholar 

  • Jongeneelen, F. J. (2001). Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure to polycyclic aromatic hydrocarbons. The Annals of Occupational Hygiene, 45, 3–13.

    CAS  Google Scholar 

  • Lee, M., Eum, K., Zoh, M., Kim, T., Pak, Y., & Paek, D. (2007). 1-Hydroxypyrene as a biomarker of PAH exposure among subjects living in two separate regions from a steel mill. International Archives of Occupational and Environmental Health, 80, 671–678.

    Article  CAS  Google Scholar 

  • Linderholm, L., Jakobsson, K., Lundh, T., Zamir, R., Shoeb, M., Nahar, N., & Bergman, Å. (2011). Environmental exposure to POPs and heavy metals in urban children from Dhaka. Bangladesh. Journal of Environmental Monitoring, 13, 2728–2734.

    Article  CAS  Google Scholar 

  • Mucha, A. P., Hryhorczuk, D., Serdyuk, A., Nakonechny, J., Zvinchuk, A., Erdal, S., Caudill, M., ScheV, P., Lukyanova, E., Shkiryak-Nyzhnyk, Z., & Chislovska, N. (2006). Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children. Environmental Health Perspectives, 114, 603–609.

    Article  CAS  Google Scholar 

  • Martínez-Salinas, R. I., Elena Leal, M., Batres-Esquivel, L. E., Domínguez-Cortinas, G., Calderón, J., Díaz-Barriga, F., & Pérez-Maldonado, I. N. (2010). Exposure of children to polycyclic aromatic hydrocarbons in Mexico: assessment of multiple sources. International Archives of Occupational and Environmental Health, 83, 617–623.

    Article  Google Scholar 

  • Martínez-Salinas, R. I., Pérez-Maldonado, I. N., Batres-Esquivel, L. E., Flores-Ramírez, R., & Díaz-Barriga, F. (2012). Assessment of DDT, DDE, and 1-hydroxypyrene levels in blood and urine samples in children from Chiapas Mexico. Environmental Science Pollution Research Internacionales, 19, 2658–2666.

    Article  Google Scholar 

  • Nhanes, I. V. (2009). Fourth national report on human exposure to environmental chemicals. Atlanta: Department of Health and Human Services Centers for Disease Control and Prevention.

    Google Scholar 

  • Pérez-Maldonado, I. N., Trejo, A., Ruepert, C., Jovel, R., Del, C., Méndez, M. P., Ferrari, M., Saballos-Sobalvarro, E., Alexander, C., Yáñez-Estrada, L., Lopez, D., Henao, S., Pinto, E. R., & Díaz-Barriga, F. (2010). Assessment of DDT levels in selected environmental media and biological samples from Mexico and Central America. Chemosphere, 78, 1244–1249.

    Article  Google Scholar 

  • Pruneda-Álvarez, L. G., Pérez-Vázquez, F. J., Salgado-Bustamante, M., Martínez-Salinas, R. I., Pelallo-Martínez, N. A., & Pérez-Maldonado, I. N. (2012). Exposure to indoor air pollutants (polycyclic aromatic hydrocarbons, toluene, benzene) in Mexican indigenous women. Indoor Air, 22, 140–147.

    Article  Google Scholar 

  • Riojas-Rodríguez, H., Schilmannm, A., Marron-Mares, A. T., Masera, O., Li, Z., Romanoff, L., Sjödin, A., Rojas-Bracho, L., Needham, L. L., & Romieu, I. (2011). Impact of the improved Patsari biomass stove on urinary polycyclic aromatic hydrocarbons biomarkers and carbon monoxide exposures in rural Mexican women. Environmental Health Perspectives, 119, 1301–1307.

    Article  Google Scholar 

  • Ruchirawat, M., Settachan, D., Navasumrit, P., Tuntawiroon, J., & Autrup, H. (2007). Assessment of potential cancer risk in children exposed to urban air pollution in Bangkok. Thailand. Toxicology Letters, 168, 200–209.

    Article  CAS  Google Scholar 

  • Schulz, C., Angerer, J., Ewers, U., Heudorf, U., Wilhelm, M., & on behalf of the Human Biomonitoring Commission of the German Federal Environment Agency. (2009). Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German Environmental Survey on Children 2003–2006 (GerES IV). International Journal of Hygiene and Environmental Health, 212, 637–647.

    Article  CAS  Google Scholar 

  • Taussky HH (1954) A micro-colorimetric determination of creatinine in urine by the JaVey’s reaction. J Biol Chem 208:853–861.

    Google Scholar 

  • Torres-Dosal, A., Pérez-Maldonado, I. N., Jasso-Pineda, Y., Martinez-Salinas, R. I., Alegría-Torres, J. A., & Díaz-Barriga, F. (2008). Indoor air pollution in a Mexican indigenous community: evaluation of risk reduction program using biomarkers of exposure and effect. Science of the Total Environment, 390, 362–368.

    Article  CAS  Google Scholar 

  • Trejo-Acevedo, A., Díaz-Barriga, F., Carrizales, L., Domínguez, G., Costilla, R., Ize-Lema, I., Yarto-Ramírez, M., Gavilán-García, A., Mejía-Saavedra, J., & Pérez-Maldonado, I. N. (2009). Exposure assessment of persistent organic pollutants and metals in Mexican children. Chemosphere, 74, 974–980.

    Article  CAS  Google Scholar 

  • Trejo-Acevedo, A., Rivero-Pérez, N. E., Flores-Ramírez, R., Orta-García, S. T., Varela-Silva, J. A., & Pérez-Maldonado, I. N. (2012). Assessment of the levels of persistent organic pollutants and 1-hydroxypyrene in blood and urine samples from Mexican children living in an endemic malaria area in Mexico. Bulletin of Environmental Contamination and Toxicology, 88, 828–832.

    Article  CAS  Google Scholar 

  • Tuntawiroon, J., Mahidol, C., Navasumrit, P., Autrup, H., & Ruchirawat, M. (2007). Increased health risk in Bangkok children exposed to polycyclic aromatic hydrocarbons from traffic-related sources. Carcinogenesis, 28, 816–822.

    Article  CAS  Google Scholar 

  • UNEP. (2012). Stockholm Convention on Persistent Organic Pollutants (POPs). Text and annexes. Geneva, Switzerland; 20011–64. Available from: www.unep.org. Accessed 16 Feb 2012.

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Acknowledgments

This work was supported by a grant from the Consejo Nacional de Ciencia y Tecnología, Mexico, CONACYT-SEMARNAT 107900.

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Authors and Affiliations

  1. Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, San Luis Potosí, 78210, SLP, México

    Iván N. Pérez-Maldonado, Antonio Trejo-Acevedo, Lucia Guadalupe Pruneda-Alvarez, Octavio Gaspar-Ramirez, Selene Ruvalcaba-Aranda & Francisco Javier Perez-Vazquez

  2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, San Luis Potosí, 78210, SLP, México

    Iván N. Pérez-Maldonado

  3. Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección, San Luis Potosí, 78210, SLP, México

    Iván N. Pérez-Maldonado, Lucia Guadalupe Pruneda-Alvarez, Octavio Gaspar-Ramirez, Selene Ruvalcaba-Aranda & Francisco Javier Perez-Vazquez

  4. Centro Regional de Investigación en Salud Publica/Instituto Nacional de Salud Pública, Chiapas, Mexico

    Antonio Trejo-Acevedo

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  1. Iván N. Pérez-Maldonado
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  2. Antonio Trejo-Acevedo
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  3. Lucia Guadalupe Pruneda-Alvarez
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  4. Octavio Gaspar-Ramirez
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  5. Selene Ruvalcaba-Aranda
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  6. Francisco Javier Perez-Vazquez
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Correspondence to Iván N. Pérez-Maldonado.

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Pérez-Maldonado, I.N., Trejo-Acevedo, A., Pruneda-Alvarez, L.G. et al. DDT, DDE, and 1-hydroxypyrene levels in children (in blood and urine samples) from Chiapas and Oaxaca, Mexico. Environ Monit Assess 185, 9287–9293 (2013). https://doi.org/10.1007/s10661-013-3251-y

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  • DOI: https://doi.org/10.1007/s10661-013-3251-y

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