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Infection fatality rate of COVID-19 in community-dwelling elderly populations

Abstract

This mixed design synthesis aimed to estimate the infection fatality rate (IFR) of Coronavirus Disease 2019 (COVID-19) in community-dwelling elderly populations and other age groups from seroprevalence studies. Protocol: https://osf.io/47cgb. Eligible were seroprevalence studies done in 2020 and identified by any of four existing systematic reviews; with ≥ 500 participants aged ≥ 70 years; presenting seroprevalence in elderly people; aimed to generate samples reflecting the general population; and whose location had available data on cumulative COVID-19 deaths in elderly (primary cutoff ≥ 70 years; ≥ 65 or ≥ 60 also eligible). We extracted the most fully adjusted (if unavailable, unadjusted) seroprevalence estimates; age- and residence-stratified cumulative COVID-19 deaths (until 1 week after the seroprevalence sampling midpoint) from official reports; and population statistics, to calculate IFRs adjusted for test performance. Sample size-weighted IFRs were estimated for countries with multiple estimates. Thirteen seroprevalence surveys representing 11 high-income countries were included in the main analysis. Median IFR in community-dwelling elderly and elderly overall was 2.9% (range 1.8–9.7%) and 4.5% (range 2.5–16.7%) without accounting for seroreversion (2.2% and 4.0%, respectively, accounting for 5% monthly seroreversion). Multiple sensitivity analyses yielded similar results. IFR was higher with larger proportions of people > 85 years. The IFR of COVID-19 in community-dwelling elderly is lower than previously reported.

Introduction

Coronavirus Disease 2019 (COVID-19) affects the elderly [1], and nursing homes residents are particularly vulnerable [2]. Numerous seroprevalence studies have been conducted in various populations, locations, and settings. These data have been used and synthesized in several published efforts to obtain infection fatality rate (IFR, proportion of deceased among those infected) estimates [3,4,5,6]. All analyses identify very strong risk-gradient based on age, although absolute risk values still have substantial uncertainty. Importantly, the vast majority of seroprevalence studies include very few elderly people [7]. Extrapolating seroprevalence from younger to older age groups is tenuous. Elderly people may genuinely have different seroprevalence. Ideally, elderly should be more protected from exposure/infection, although probably the ability to protect the elderly has varied substantially across countries [8]. Moreover, besides age, comorbidities and lower functional status markedly affects COVID-19 death risk [9, 10]. Particularly long-term care residents accounted for 30–70% of COVID-19 deaths in high-income countries in the first wave [2], despite comprising < 1% of the population. IFR in nursing home residents may be as high as 25% [11]. Not separating persons living in institutions from the community-dwelling may provide an average that is too low for the former and too high for the latter. Moreover, ascertainment and reporting of COVID-19 cases and deaths in long-term care facilities show considerable variation across countries [2], with potentially heavy bearing on overall mortality, while community-dwelling elderly data may be less unreliable (especially in high-income countries). Finally, seroprevalence estimates reflect typically community-dwelling populations (enrollment of people living in institutions is scarce/absent in serosurveys).

Here we estimated the COVID-19 IFR in community-dwelling populations at all locations where seroprevalence studies with many elderly individuals have been conducted.

Methods

Information sources

We identified seroprevalence studies (peer-reviewed publications, official reports, or preprints) in four existing systematic reviews [3, 7, 12, 13] as for a previous project [14], using the most recent updates of these reviews and their respective databases as of November 23, 2021. All systematic reviews may miss some studies, despite their systematic efforts. Here, the risk is minimized by using several existing systematic reviews of seroprevalence studies, each of them very meticulous. The protocol of this study was registered at the Open Science Framework (https://osf.io/47cgb) after piloting data availability in December 2020 but before extracting full data, communicating with local authorities and study authors for additional data and performing any calculations. Protocol amendments and their justification appear in Online Appendix Table 1.

Eligibility criteria

In the original protocol, we aimed to include studies on SARS-CoV-2 seroprevalence that had sampled at least 1000 participants aged ≥ 70 years in the location and/or setting of interest, provided an estimate of seroprevalence for elderly people, explicitly aimed to generate samples reflecting the general population, and were conducted at a location for which there is official data available on the proportion of cumulative COVID-19 deaths among elderly (with a cutoff placed between 60 and 70 years; e.g., eligible cutoffs were ≥ 70, ≥ 65, or ≥ 60, but not ≥ 75 or ≥ 55). Following comments from peer-reviewers, we also included national-level general population studies without high risk of bias and with at least 500 participants aged ≥ 70 years (since studies with 500–1000 may still yield reasonably precise estimates of seroprevalence in the elderly) and we excluded samples of patient cohorts, insurance applicants, blood donors, and workers (that were intended for inclusion in the original protocol). These convenience samples with ≥ 1000 participants aged ≥ 70 years are now considered only in a sensitivity analysis. USA studies were excluded if they did not adjust seroprevalence for race or ethnicity, since these socio-economically related factors may associate strongly with both study participation [15, 16] and COVID-19 burden [17,18,19]. Following comments from peer-reviewers, we have added another exclusion criterion: crude seroprevalence being less than 1-test specificity and/or the 95% confidence interval of the seroprevalence going to 0% (since the seroprevalence estimate would be extremely uncertain). Following comments from peer-reviewers, we also considered only studies from high-income countries in the primary analysis, since there can be substantial uncertainty about the number of deaths in other countries. We focused on studies sampling participants in 2020, since IFRs in 2021 may be further affected by wide implementation of vaccinations that may substantially decrease fatality risk and by other changes (new variants and better treatment). We applied risk of bias assessments reported by SeroTracker (based on the Joanna Briggs Institute Critical Appraisal Tool for Prevalence Studies) [20]. Two authors reviewed records for eligibility. Discrepancies were solved by discussion.

Data extraction

CA extracted each data point and JPAI independently verified the extracted data. Discrepancies were solved through discussion. For each location, we identified the age distribution of cumulative COVID-19 deaths and chose as primary age cutoff the one closest to 70, while placed between 60 and 70 years (e.g., ≥ 70, ≥ 65, or ≥ 60).

Similar to a previous project [3], we extracted from eligible studies information on location, recruitment and sampling strategy, dates of sample collection, sample size (overall and elderly group), and types of antibody measured (immunoglobulin G (IgG), IgM and IgA). We also extracted, for the elderly stratum, the estimated unadjusted seroprevalence, the most fully adjusted seroprevalence, and the factors considered for adjustment. Antibody titers may decline over time. E.g. a modelling study estimated 3–4 months average time to seroreversion [21]. A repeated measurements study [22] suggests even 50% seroreversion within a month for asymptomatic/oligosymptomatic patients, although this may be an over-estimate due to initially false-positive antibody results. To address seroreversion, if there were multiple different time points of seroprevalence assessment, we selected the one with the highest seroprevalence estimate. If seroprevalence data were unavailable as defined by the primary cutoff, but with another eligible cutoff (e.g., ≥ 70, ≥ 65, or ≥ 60), we extracted data for that cut-off.

Population size (overall, and elderly) and numbers of long-term care residents for the location were obtained from multiple sources (Online Appendix Table 2).

Cumulative COVID-19 deaths overall and in the elderly stratum (using the primary age cutoff) for the relevant location were extracted from official reports. Total numbers, i.e., confirmed and probable, was preferred whenever available. We extracted the accumulated deaths until 1 week after the midpoint of the seroprevalence study period (or closest date with available data) to account for different delays in developing antibodies versus dying from infection [23, 24]. If the seroprevalence study claimed strong arguments to use another time point or approach, while reporting official statistics on number of COVID-19 deaths overall and in the elderly, we extracted that number instead.

The proportion of cumulative COVID-19 deaths that occurred among long-term care residents for the relevant location and date was extracted from official sources or the International Long Term Care Policy Network (ILTCPN) report closest in time [2, 25]. We defined community-dwelling individuals by excluding persons living in institutions. Types of institutions used for elderly in various countries differed in nature and in the frailty of residents. For each location, we extracted available definitions of institutions. We preferred numbers recorded per residence status, i.e., including COVID-19 deaths among nursing home residents occurring in hospital. If the latter were unavailable, we calculated total number of deaths in residents with a correction (by multiplying with the median of available ratios of deaths in nursing homes to deaths of nursing home residents in the ILTCPN 10/14/2020 report [2] for countries in the same continent). We considered 95%, 98%, and 99% of residents’ deaths to have occurred in people ≥ 70 years, ≥ 65 years and ≥ 60 years, respectively [26]. For other imputations, see the online protocol.

Missing data

We communicated with the authors of the seroprevalence study and with officers responsible for compiling the relevant official reports to obtain missing information or when information was available but not for preferred age cut-offs. Email requests were sent, with two reminders to non-responders.

Calculated data variables

Infected and deceased community-dwelling elderly

The number of infected people among the community dwelling elderly for the preferred date (1 week after the midpoint of the seroprevalence study period) was estimated by multiplying the adjusted estimate of seroprevalence and the population size in community-dwelling elderly. We preferred the most adjusted seroprevalence estimates. Following a suggestion from peer-reviewers, whenever no adjustment was made for test performance, we adjusted the estimates for test performance using the Gladen–Rogan formula [27] and did not correct for types of unmeasured antibodies (IgG/IgM/IgA) [3, 28]. Moreover, we applied a non-prespecified correction for studies that excluded persons with diagnosed COVID-19 from sampling, primarily by using study authors’ corrections, secondarily by adding the number of identified COVID-19 cases in community-dwelling elderly for the location up to the seroprevalence study midpoint.

The total number of fatalities in community-dwelling elderly was obtained by total number of fatalities in elderly minus those accounted for by long-term care residents in the elderly stratum. If the elderly proportion or residents’ share of COVID-19 deaths were only available for another date than the preferred one, we assumed the proportions were stable between time points.

IFR estimation

We added a non-prespecified calculation of 95% confidence intervals (CIs) of IFRs based on extracted or calculated 95% CIs from seroprevalence estimates (Online Appendix Table 1). No further factors were introduced in the calculation beyond Gladen–Rogan corrections where no adjustment had been done for test performance. CI estimates should be seen with caution since they depend on adequacy of seroprevalence adjustments, and do not consider other types of uncertainty (e.g., regarding mortality statistics).

Synthesis of data

Statistical analyses used R version 4.0.2 [29]. Similar to a previous overview of IFR-estimating studies [3], we estimated the sample size-weighted IFR of community-dwelling elderly for each country and then estimated the median and range of IFRs across countries. As expected, there was extreme heterogeneity among IFR estimates (I2 = 99.1%), thus weighted meta-analysis averages are not meaningful [30, 31].

We explored a seroreversion correction of the IFR by Xm-fold, where m is the number of months from the peak of the first epidemic wave in the specific location and X is 0.99, 0.95, and 0.90 corresponding to 1%, 5%, and 10% relative monthly rate of seroreversion [21, 22, 32]. We also added a non-prespecified sensitivity analysis to explore the percentage increase in the cumulative number of deaths and IFR, if the cutoff was put 2 weeks (rather than 1 week) after the study midpoint.

We expected IFR would be higher in locations with a higher share of people ≥ 85 years old among the analyzed elderly stratum. Estimates of log10IFR were plotted against the proportion of people ≥ 85 years old among the elderly (for population pyramid sources see Online Appendix Table 2).

Ethics approval

Not applicable to this study.

Patient and public involvement

There was no involvement of patients nor the public in this research.

Results

Seroprevalence studies

By November 23, 2021, 3138 SARS-CoV-2 seroprevalence reports were available in the four systematic reviews. Screening and exclusions are shown in Online Appendix Figure 1 and Online Appendix Table 3. Twelve seroprevalence studies were included, one of which contained two separate surveys; another 13 studies with convenience samples were considered in sensitivity analysis [33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48,49,50,51,52,53,54,55,56].

Table 1 shows for each study the sampling period, sample size tested and positive, age cut-offs for the elderly group, antibody type(s), seroprevalence estimates, types of adjustments, number of deaths, and IFR estimates. The 13 seroprevalence surveys in the main analysis (Table 1) represented 11 countries (Americas n = 2, Europe n = 11). Three studies excluded upfront persons with previously diagnosed COVID-19 from participating in their sample [53, 57, 58]. Mid-sampling points ranged from May 2020 to November 2020. Sampling had a median length of 5.4 weeks (range 13 days to 5 months). The median number of elderly individuals tested was 1473 (range 788–21,953). Median seroprevalence was 3.2% (range 0.47–14.9%). Adjusted seroprevalence estimates were available for 12/13 surveys.

Table 1 Included seroprevalence studies with estimates of seroprevalence in the elderly, COVID-19 deaths in the elderly and community-dwelling elderly, and corrected infection fatality rate

Mortality and population statistics

COVID-19 deaths and population data among elderly at each location are shown in Table 1 (for sources, see Online Appendix Table 2). The proportion of a location’s total COVID-19 deaths that happened among elderly had a median of 86% (range 70–93%) in high-income countries. The proportion of a location’s total COVID-19 deaths that occurred in long-term care residents had a median of 39% (range 20–67%) in in high-income countries with available data (for Qatar, the number was imputed). One study [55] included only COVID-19 deaths that occurred in nursing homes and was corrected to reflect also the deaths among residents occurring in hospitals. Among the population, the elderly group comprised a median of 14% (range 10–24%) in high-income countries. People residing in facilities were 4.8% (range 2.9–8.8%) in high-income countries.

Additional data contributed

Additional information was obtained from authors and agencies on four studies for seroprevalence data [50, 56, 59, 60]; four studies for mortality data [49, 50, 34, 43]; two studies for population data [49, 50]; and five excluded studies (clarifying non-eligibility).

Calculated IFRs

For countries with more than one IFR estimate available sample size-weighted average IFRs were calculated. In 11 high-income countries, IFRs in community-dwelling elderly (Fig. 1, Table 1) had a median of 2.9% (range 1.8–9.7%). Figure 1 also shows 95% CIs for IFRs based on 95% CIs for seroprevalence estimates. For 5 studies, 95% CIs were direct extractions from the seroprevalence studies themselves, while complementary calculations were performed for the others as described in Online Appendix Table 1. For 9 studies, seroprevalence estimates were corrected for test performance using the Gladen–Rogan formula (Online Appendix Table 4). Median IFR in all elderly for all 11 high-income countries was 4.5% (range 2.5–16.7%). Of the 13 included estimates, the IFR in community-dwelling elderly was > 30% lower than the IFR among all elderly in 10/13 and > 50% lower in 1/13.

Fig. 1
figure 1

Infection fatality rates (IFRs) in elderly, corrected for unmeasured antibody types. a Countries’ IFRs in community-dwelling elderly and elderly overall. b IFRs in community-dwelling elderly with 95% confidence intervals based on individual seroprevalence estimates and their uncertainty. If multiple seroprevalence studies were available for the same country, we calculated the sample size-weighted IFR. As per above, the 95% CIs do not take into account other sources of uncertainty than those adjusted by the seroprevalence study authors (except adding an adjustment for test performance as per the Gladen–Rogan formula for those that had not already adjusted for test performance), and should be interpreted as conservative. Primarily, 95% confidence intervals are direct extractions from the seroprevalence studies. For studies that did not report 95% confidence intervals, we complemented with a calculation using the number of sampled and seropositive elderly individuals. For those that provided adjusted estimates for age brackets (e.g., 70–79, 80–89, and 90+), we combined estimates for each study using a fixed effects inverse variance meta-analysis (of arcsine transformed proportions) to obtain 95% CIs. Asymmetry to point estimates may be observed for these cases, since point estimates were calculated by multiplying age bracket seroprevalence by the corresponding population count (which is preferable, since it takes into account population distribution)

With 5% relative monthly seroreversion, median IFR in community-dwelling elderly in 11 high-income countries was 2.2% (4.0% in all elderly—see details on seroreversion analyses in Online Appendix Table 5). Online Appendix Table 6 shows calculations with later cut-off for counting deaths.

The median IFR was 2.7% upon excluding 3 studies where the selected time point with highest seroprevalence was not the latest available (seroprevalence had declined in the latest timepoint) [56,57,58]. The median IFR was 2.8% in 15 countries when applying the non-peer-reviewed pre-specified original eligibility criteria (including convenience samples, including 2 middle-income countries, and correcting for unmeasured antibodies).

IFR in the elderly and proportion > 85 years

IFR tended to increase with larger proportions of people ≥ 85 years old (Fig. 2). A regression of logIFR against the proportion of people ≥ 85 years old had a slope of 0.03 (p = 0.17), and suggested an IFR in community-dwelling elderly of 1.21%, 1.79%, and 3.89% when the proportion of people > 85 in the elderly group was 5%, 10%, and 20%, respectively. Using the set of studies in the pre-specified original eligibility criteria, the slope was 0.06 (p = 0.001), with IFR 0.41%, 0.81%, and 3.25% for the respective proportions.

Fig. 2
figure 2

Infection fatality rate in community-dwelling elderly, corrected for unmeasured antibody types, plotted against the proportion of people ≥ 85 years old among the elderly. Log10 IFR: logarithm (with base 10) of the infection fatality rate. The “elderly” group is defined by the primary cutoff for each location. E.g. for the USA 2% of the population is ≥ 85, 16.5% of the population is ≥ 65, and the proportion is 2/16.5. Imputation done for Tamil Nadu, India, with country-level proportion of persons ≥ 85 years old among elderly

Discussion

The IFR of COVID-19 in elderly was found to vary widely at locations where seroprevalence studies have enrolled many elderly individuals. IFR in community-dwelling elderly was consistently lower than in elderly overall. In countries where nursing homes are widely used, the difference was very substantial.

Early estimates of case fatality rate (CFR, ratio of deaths divided by documented infections) [59,60,61] were very high. However, infected individuals far exceeded documented cases [62]. IFR is much lower than CFR. Our work represents the only effort to-date to synthesize data on age-stratified IFR estimates using a detailed prespecified and registered protocol, with justifications whenever further decisions had to be made. See Online Appendix Text 1 for comparison of our IFR estimates against previous relevant work [4, 5, 63, 64]. Our estimates, when inferred for the USA, are distinctly lower than the current Centers for Disease Control and Prevention best planning scenario [63]. IFR estimates in the elderly are still extremely higher than IFR in younger age groups (Online Appendix Text 1).

Substantial true heterogeneity is expected since IFR is situation- and population-dependent. Both age distribution and other characteristics of people within the elderly stratum vary between different countries. Moreover, criteria for coding COVID-19 deaths may have varied across countries. Under- and over-counting of COVID-19 deaths probably occurred even in countries with advanced health systems.

Observed differences in IFR between community-dwelling elderly and elderly overall are consistent with previous findings that beyond age, comorbid conditions and frailty drive COVID-19 mortality [10]. People living in institutions account for many COVID-19 deaths [65], thus a location’s overall IFR is largely dependent on how these facilities were afflicted [5]. Spread in nursing homes was disproportionately high in the first wave [8]. IFR in residents can be much higher than the IFR in community-dwelling elderly. Seroprevalence studies of long-term care populations in Spain (Madrid), northern Italy, UK and Brazil in early phases of the epidemic found prevalence of 55%, 41%, 33%, and 11.5%, respectively [66,67,68,69,70], i.e. several fold higher than prevalence in the general community populations in these locations. Under-estimation of infections due to seroreversion may also be prominent in such studies [60]. Large diversity in seroprevalence can exist between facilities, e.g. in Brazil [69] the seroprevalence was 100% and 76%, respectively in 2 nursing homes that had outbreaks and 0% or close to 0% in another 13. The IFR in that study was 25%, a reasonable estimate for nursing homes with rather frail populations, as corroborated also by other investigators [11]. IFR may be much lower in facilities where residents in overall good health plan to spend many years of their life; but extremely high in palliative care facilities. Furthermore, our estimates of IFR among community-dwelling elderly are probably inflated, because in some countries not all long-term care facilities were included in the count of long-term care deaths.

Nursing home deaths decreased markedly over time [65] in most high-income countries. This change may have decreased IFR markedly after the first wave. Improved treatments and less use of harmful treatments may also have decreased IFR substantially in late 2020 and 2021 [71, 72]. Other investigators estimated in 2020 a global IFR of 0.11% [73]. Vaccines that are more effective in protecting against death rather than infection are also expected to have decreased IFR in 2021. New variants in 2021 may be associated with further lower IFR. E.g., in countries with extensive testing such as the UK, when the delta variant spread widely even CFR remained ~ 0.3% [74]. Preliminary data on the omicron variant in late 2021 suggest even lower severity [75].

Our analysis has several limitations. First, seroprevalence estimates among elderly reported by the included studies could over- or underestimate the proportion infected. We explored adjusted estimates accounting for 1–10% relative seroreversion per month; however, higher seroreversion is likely [21, 22, 32]. Higher seroreversion will affect more prominently studies carried out later in the pandemic. Also, the current estimates do not fully account for the unknown share of people who may have tackled the infection without generating detectable serum/plasma antibodies (e.g., by mucosal, innate, or cellular [T cell] immune mechanisms) [76,77,78,79,80]. Sensitivity estimates for antibody assays typically use positive controls from symptomatic individuals with clinically manifest infection; sensitivity may be lower for asymptomatic infections. All seroprevalence studies may have substantial residual biases despite whatever adjustments [6]. Even well-designed general population studies may specifically fail to reach and recruit highly vulnerable populations, e.g. disadvantaged groups, immigrants, homeless, and other people at high exposure risks and poor health. For studies carried out in the US, we prespecified an eligibility criterion to adjust for race/ethnicity, which we believe acts to mitigate related biases. COVID-19-related racial/ethnic differences were expected to be stronger in the USA than in other high-income countries, and racial/ethnic diversity is far more prominent in the USA (e.g. 57.8% of the population identify as non-Hispanic white, while the proportion is over 90% in Denmark and 85% in France).

Second, numbers of deaths may be biased for various reasons [3] leading to potential under- or over-counting. Underreporting of deaths is debated specifically for India (e.g., [81]). Online Appendix Text 2 discusses issues related to India and other non-high income countries and explains why simple excess death estimates should not be used to calculate IFR [82].

Sensitivity analysis that extended with 1 week the cutoff for counting deaths showed a negligible change in estimated median IFR. Most studies included in our analysis had been performed during periods at or after the end of the first wave. Some studies performed sampling for several months, which introduces further uncertainty. However, typically the sampling covered periods with few fatalities.

Third, bias exists in seroprevalence studies, mortality statistics, and even population statistics. However, assessments of risk of bias are far from straightforward, as illustrated by discrepant assessments of these seroprevalence studies by other teams [6]. Moreover, estimates cited here have uncertainty going beyond the presented 95% CIs. Others, e.g., Campbell and Gustafson [83], have proposed models that incorporate additional uncertainty.

Fourth, even among high-income countries, our set of eligible surveys tends to include mostly data from countries with higher death rates, thus possibly also higher IFR. More prominently, our analysis includes limited data from Asia and no data from Africa. Consideration of age strata diminishes this representativeness bias, but cannot eliminate it. E.g., most countries not represented may have a shift towards lower ages within the elderly stratum. This translates to lower IFR. Moreover, high-income countries analyzed here have population prevalence of obesity 1.5–3-fold higher than the global prevalence (13%); other major risk factors for poor COVID-19 outcome (smoking, diabetes, cardiovascular disease, immunosuppression) [9] are also far more common in the high-income countries included in our analysis than the global average. Global IFR may thus be substantially lower in both the elderly and the lower age strata than estimates presented herein.

Fifth, many complementary pieces of information were needed beyond the systematic search for seroprevalence studies. Some decisions made in this process, e.g., the eligibility criterion of having many elderly participants, could be described as arbitrary. This rule was introduced for feasibility and validity, since small samples are largely uninformative (given the huge uncertainty). The rule tends to prefer studies in populations with old age pyramids and many frail individuals who survive into late age with many comorbidities.

This overview synthesis finds a consistently lower IFR of COVID-19 in community-dwelling elderly than in elderly overall, a difference which is substantial in countries with many long-term care facilities. The estimates presented here may help inform public health policy decisions.

Data availability

The protocol, data, and code used for this analysis will be made available at the Open Science Framework upon publication: https://osf.io/47cgb.

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Acknowledgements

We thank sincerely Eva Heras Muxella, Cristina Royo-Cebrecos (Andorra), Sereina Herzog (Belgium), Ilse Peeters and Catharina Vernemmen at Sciensano, the Belgian Institute for Health (Belgium), Zoltán Vokó (Hungary), Peter Coyle, Laith Abu-Raddad (Qatar) for personal communication of seroprevalence and/or COVID-19 mortality statistics; and Giridhara D Babu, Rajesh Sundaresan, Siva Athreya (India), N. Ahmad Aziz, Monique M.B. Breteler (Germany), Public Health Scotland (Scotland), Office for National Statistics, Infection Survey Analysis (UK), Cesar Victora, Fernando Hartwig, Luis Vidaletti (Brazil), Prabhat Jha (Toronto) and Kastytis Šmigelskas (Lithuania) for personal communication to clarify non-eligibility. We thank the dedicated members of the SeroTracker and Worldometer teams as well as Wikipedia authors for their efforts to gather information on seroprevalence studies and COVID-19 mortality statistics.

Funding

No funding was received specifically for this work. Outside this work, the Meta-Research Innovation Center at Stanford (Stanford University) is supported by a grant from the Laura and John Arnold Foundation. Dr Axfors is supported by postdoctoral grants from the Knut and Alice Wallenberg Foundation, Uppsala University, the Swedish Society of Medicine, the Blanceflor Foundation, and the Sweden-America Foundation. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

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The corresponding author attests that both listed authors meet authorship criteria and that no others meeting the criteria have been omitted. CA: conceptualization, methodology, software, formal analysis, investigation, data curation, writing—original draft, visualization, project administration. JPAI: conceptualization, methodology, formal analysis, investigation, data curation, writing—review and editing, visualization, supervision.

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Correspondence to John P. A. Ioannidis.

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Axfors, C., Ioannidis, J.P.A. Infection fatality rate of COVID-19 in community-dwelling elderly populations. Eur J Epidemiol 37, 235–249 (2022). https://doi.org/10.1007/s10654-022-00853-w

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Keywords

  • COVID-19
  • Infection fatality rate
  • Elderly