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Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy

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A Correction to this article was published on 11 March 2021

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Summary

This study reports the results of a monocentric prospective analysis conducted with the aim of evaluating the impact of XRCC1 rs25487, XRCC3 rs861539, XRCC3 rs1799794, RAD51 rs1801320 and GSTP-1 rs1695 single nucleotide polymorphisms (SNP) on patients with high-grade glioma treated with concomitant radio-chemotherapy. From October 2010 to August 2019, a total of 75 patients aged ≥18 years, with histological diagnosis of high-grade glioma, isocitrate dehydrogenase (IDH) 1/2 wild type and treated with radio-chemotherapy and sequential chemotherapy with temozolomide (TMZ) were prospectively recruited. The local ethic committee approved this study (Comitato Etico di Area Vasta Nord Ovest [CEAVNO]; protocol 3304/2011). After a median follow up of 25 months (range: 7–98 months), median progression-free survival (PFS) and overall survival (OS) were 11 months (CI95%: 8–14 months) and 18 months (CI95%: 15–21 months), respectively. In univariate and multivariate Cox regression analysis, a statistically significant association with PFS and OS was found with XRCC3 rs1799794 SNP. The study suggests that XRCC3 rs1799794 SNP can be associated with different PFS and OS in glioblastoma patients treated with radio-chemotherapy.

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Acknowledgements

The authors would like to thank Fondazione Arpa for its support through the project Luca Gambicor.

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Authors and Affiliations

  1. Radiation Oncology Unit, Pisa University Hospital, Via Roma 67, 56123, Pisa, Italy

    Francesco Pasqualetti, Alessandra Gonnelli, Eleonora Palladino, Noemi Giannini, Giovanni Gadducci, Roberto Mattioni, Sabrina Montrone, Elisa Calistri & Fabiola Paiar

  2. Department of Clinical and Experimental Medicine, University of Pisa, I-56126, Pisa, Italy

    Paola Orlandi & Guido Bocci

  3. Laboratory of Genomics and Transcriptomics, Fondazione Pisana per la Scienza, Pisa, Italy

    Chiara Maria Mazzanti, Sara Franceschi & Cristian Scatena

  4. Department of Translational Research and new technologies in Medicine and Surgery, University of Pisa, 56100, Pisa, Italy

    Valerio Ortenzi, Giuseppe Nicolo Fanelli & Giuseppe Antonio Naccarato

  5. Division of Molecular Genetics, Department of Laboratory Medicine, Pisa University Hospital, Pisa, Italy

    Katia Zavaglia

  6. Section of Statistics, Azienda Ospedaliero-Universitaria Pisana, Pisa University Hospital, Pisa, Italy

    Riccardo Morganti

  7. Nurosurgery Unit, Area Vasta-NordOvest, Livorno General Hospital, Livorno, Italy

    Orazio Santonocito

Authors
  1. Francesco Pasqualetti
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  2. Alessandra Gonnelli
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Contributions

All authors whose names appear on the submission made substantial contributions to the conception or design of the work, or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; drafted the work or revised it critically for important intellectual content; approved the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or.

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Correspondence to Francesco Pasqualetti.

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Comitato Etico di Area Vasta Nord Ovest CEAVNO; protocol #560.

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This article does not contain any studies involving animals performed by any of the authors.

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Pasqualetti, F., Gonnelli, A., Orlandi, P. et al. Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy. Invest New Drugs 39, 1159–1165 (2021). https://doi.org/10.1007/s10637-021-01075-9

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