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Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo

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Summary

Quinolines and acrylates are chemical compounds which were previously described as potential antitumor agents. In this study, a series of seven new quinolinyl acrylate derivatives were synthesized and evaluated against human prostate cancer cells PC-3 and LNCaP in vitro and in vivo. The most effective compound (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4 hydroxyphenyl) acrylate reduced the viability in both cell lines in a time- and dose-dependent manner. Inhibitory effects were also observed on the adhesion, migration, and invasion of the prostate cancer cells as well as on the neoangiogenesis, clonogenic and MMP-9 activity. The effect in vivo was studied in PC-3 xenografts in nude mice. The results were concordant with the in vitro effects and showed decreased tumor growth in treated animals compared to controls. The study suggests the multi-target efficacy of the quinolinyl derivate against human prostate cancer cells and supports its potential therapeutic usefulness.

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Acknowledgements

This study was partly supported by grants from the Foundation Urological Research, Berlin to CA, JR, and ML (Grant no. GRUB-3), the German Academic Exchange Service (DAAD) to JR (Grant no. Referat 414, A/07/98623) and CDCH-UCV (Grant no. PG-06-7548-2009/1). We thank Sabine Becker for her valuable technical assistance.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, 10117, Berlin, Germany

    Juan R. Rodrigues, Michael Lein, Klaus Jung & Claudia Abramjuk

  2. Berlin Institute for Urologic Research, Berlin, Germany

    Juan R. Rodrigues, Bianca Nitzsche, Michael Lein, Klaus Jung & Claudia Abramjuk

  3. Laboratory of Organic Synthesis and Laboratory of Biochemistry, School of Pharmacy, Central University of Venezuela, Caracas, Venezuela

    Jaime Charris, Rosa Ferrer & Neira Gamboa

  4. Laboratory of Organic Synthesis and Drug Design, Department of Chemistry, School of Experimental Sciences, University of Zulia, Maracaibo, Venezuela

    Jorge Ángel

  5. Department of Physiology, University Hospital Charité, Campus Benjamin Franklin, Berlin, Germany

    Bianca Nitzsche & Michael Hoepfner

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  1. Juan R. Rodrigues
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Correspondence to Klaus Jung.

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Rodrigues, J.R., Charris, J., Ferrer, R. et al. Effect of quinolinyl acrylate derivatives on prostate cancer in vitro and in vivo. Invest New Drugs 30, 1426–1433 (2012). https://doi.org/10.1007/s10637-011-9716-3

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  • DOI: https://doi.org/10.1007/s10637-011-9716-3

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