Abstract
Purpose
To study the clinical use and efficacy of electrophysiology in children.
Methods
This was a retrospective review of all children aged <16 years, who were referred to the Visual Electrophysiology Laboratory at the Singapore National Eye Center between 2003 and 2013.
Results
A total of 586 children, median age 8 years (range 0.15–16), were referred for a variety of reasons including investigation of poor vision (40 %), suspected retinal disease or optic nerve/cortical dysfunction (17 %), nystagmus (13 %) and screening or monitoring of a variety of ocular or neurological conditions (12 %). The number of children with vision 6/15 or worse was 418 (71 %), and 103 (18 %) had vision 6/120 or worse in at least one eye. The most common pathology noted was retinal dystrophy or dysfunction (41 %) or optic nerve/cortical dysfunction (12 %). In 30 %, visual electrophysiology was within normal limits, and in 6 %, a conclusive diagnosis could not be obtained.
Conclusion
Electrophysiology testing played an important role in the assessment of children and added to the clinical management of the patient.
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References
van Genderen M, Riemslag F, Jorritsma F, Hoeben F, Meire F, Stilma J (2006) The key role of electrophysiology in the diagnosis of visually impaired children. Acta Ophthalmol Scand 84:799–806
Camuglia JE, Greer RM, Welch L, Gole GA (2011) Use of the electroretinogram in a paediatric hospital. Clin Exp Ophthalmol 39:506–512
Parness-Yossifon R, Mets MB (2008) The electroretinogram in children. Curr Opin Ophthalmol 19:398–402
Hidajat RR, Goode DH (2001) The clinical value of ophthalmic electrodiagnosis in children. Australas Phys Eng Sci Med 24:172–176
Bach M, Hawlina M, Holder GE, Marmor MF, Meigen T, Vaegan, Miyake Y (2000) Standard for pattern electroretinography. Int Soc Clin Electrophysiol Vis Doc Ophthalmol 101:11–18
Odom JV, Bach M, Brigell M, Holder GE, McCulloch DL, Tormene AP, Vaegan (2010) ISCEV standard for clinical visual evoked potentials (2009 update). Doc Ophthalmol 120:111–119
Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, Marmor MF, McCulloch DL, Palmowski-Wolfe AM (2012) ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol 124:1–13
McCulloch DL, Marmor MF, Brigell MG, Hamilton R, Holder GE, Tzekov R, Bach M (2015) ISCEV Standard for full-field clinical electroretinography (2015 update). Doc Ophthalmol 130:1–12
National Population and Talent Division, P. M. S. O., Singapore Department of Statistics, Ministry of Home Affairs, Immigration and Checkpoints Authority. (2015) 2015 population in Brief, http://population.sg/population-in-brief/files/population-in-brief-2015.pdf
Singapore MOH (2015) Health Facts Singapore
Fulton AB, Brecelj J, Lorenz B, Moskowitz A, Thompson D, Westall CA (2006) Pediatric clinical visual electrophysiology: a survey of actual practice. Doc Ophthalmol 113:193–204
Brodie SE (2014) Tips and tricks for successful electroretinography in children. Curr Opin Ophthalmol 25:366–373
Brecelj J, Stirn-Kranjc B (2004) Visual electrophysiological screening in diagnosing infants with congenital nystagmus. Clin Neurophysiol 115:461–470
Surachatkumtonekul T, Ruangvaravate N, Sriyakul C (2009) Visual electrophysiology in congenital nystagmus with normal fundus. J Med Assoc Thail 92:224–228
Grønskov K, Ek J, Brondum−Nielsen K (2007) Oculocutaneous albinism. Orphanet J Rare Dis 2(2):43
Harding GF, Robertson K, Spencer EL, Holliday I (2002) Vigabatrin; its effect on the electrophysiology of vision. Doc Ophthalmol 104:213–229
Hammoudi DS, Lee SS, Madison A, Mirabella G, Buncic JR, Logan WJ, Snead OC, Westall CA (2005) Reduced visual function associated with infantile spasms in children on vigabatrin therapy. Invest Ophthalmol Vis Sci 46:514–520
Westall CA, Wright T, Cortese F, Kumarappah A, Snead OC, Buncic JR (2014) Vigabatrin retinal toxicity in children with infantile spasms: an observational cohort study. Neurology 83(24):2262–2268
AAPOS (2012) Vigabatrin: the problem of monitoring for peripheral vision loss in children. http://www.aapos.org/client_data/files/2012/504_vigabatrin_05.09.12.pdf
Bain KE, Beatty S, Lloyd C (2000) Non-organic visual loss in children. Eye (Lond) 14(Pt 5):770–772
Raghunandan A, Buckingham RS (2008) The utility of clinical electrophysiology in a case of nonorganic vision loss. Optometry 79:436–443
Hamel CP (2007) Cone rod dystrophies. Orphanet J Rare Dis 2:7
Hamel C (2006) Retinitis pigmentosa. Orphanet J Rare Dis 1:40
Boycott KM, Sauve Y, MacDonald IM (1993) X-linked congenital stationary night blindness. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K (eds) GeneReviews(R) University of Washington, Seattle University of Washington, Seattle. All rights reserved, Seattle, WA
Kim JM, Payne JF, Yan J, Barnes CS (2012) Negative electroretinograms in the pediatric and adult population. Doc Ophthalmol 124:41–48
Taylor MJ, McCulloch DL (1992) Visual evoked potentials in infants and children. J Clin Neurophysiol 9:357–372
Andreasson S, Tornqvist K, Ehinger B (1993) Full-field electroretinograms during general anesthesia in normal children compared to examination with topical anesthesia. Acta Ophthalmol (Copenh) 71:491–495
Raitta C, Karhunen U, Seppalainen AM (1982) Changes in the electroretinogram and visual evoked potentials during general anaesthesia using enflurane. Graefes Arch Clin Exp Ophthalmol 218:294–296
Chin KC, Taylor MJ, Menzies R, Whyte H (1985) Development of visual evoked potentials in neonates. A study using light emitting diode goggles. Arch Dis Child 60:1166–1168
Brecelj J (2003) From immature to mature pattern ERG and VEP. Doc Ophthalmol 107:215–224
Lenassi E, Likar K, Stirn-Kranjc B, Brecelj J (2008) VEP maturation and visual acuity in infants and preschool children. Doc Ophthalmol 117:111–120
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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This study including a waiver of consent due to the retrospective nature of the study was approved by the Singhealth Central Institutional Research Board.
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Tan, A.C.S., Chen, L., Png, R. et al. The diagnosis and assessment of visual function in Singaporean children with electrophysiology: 10-year results. Doc Ophthalmol 132, 189–199 (2016). https://doi.org/10.1007/s10633-016-9539-9
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DOI: https://doi.org/10.1007/s10633-016-9539-9