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Investigation of the temporal properties of the retina using the m-sequence

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Abstract

The mfERG provides a topographic map of function of the retina and has been used in numerous studies to identify macular, paramacular and peripheral retinal dysfunction. This study investigates the changes in response due to the presentation rate of the stimulus. Twenty subjects gave informed consent to take part in the study, which had local regional ethical committee approval. Only a single hexagon of 8° diameter was presented to reduce ambiguity when identifying the higher-order kernels (HOK). Six rates were tested using a 60-Hz CRT monitor by introducing blank (black ~0 cd/m2) filler frames (FF). The rates tested were 0FF; 1FF; 2FF; 4FF; 7FF; and 14FF. The first-order kernel had largest responses to the slower stimuli (4FF and above). HOK had largest amplitudes at faster rates with the second-order kernel peaking at 1FF. At rates with 4FF and slower, the higher-order kernels were indiscernible above the noise.

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Abbreviations

FF:

Filler frame

FOK:

First-order kernel

HOK:

Higher-order kernel

SOK:

Second-order kernel first slice

SOSS:

Second-order kernel second slice

TOK:

Third-order kernel

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Authors and Affiliations

  1. Department of Medical Physics and Clinical Engineering, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK

    Richard P. Hagan, Anthony C. Fisher & Malcolm C. Brown

  2. Clinical Eye Research Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK

    Richard P. Hagan

Authors
  1. Richard P. Hagan
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  2. Anthony C. Fisher
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  3. Malcolm C. Brown
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Corresponding author

Correspondence to Richard P. Hagan.

Additional information

Study was NHS trust approved and conducted as part of job role.

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Hagan, R.P., Fisher, A.C. & Brown, M.C. Investigation of the temporal properties of the retina using the m-sequence. Doc Ophthalmol 123, 179–185 (2011). https://doi.org/10.1007/s10633-011-9295-9

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  • DOI: https://doi.org/10.1007/s10633-011-9295-9

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