Abstract
In this review, we summarize our in vivo studies of retinal pathophysiology in experimental models of retinopathy of prematurity, which were largely focused on the temporal and spatial links between retinal neovascularization (NV), vascular oxygenation, and intraretinal ion regulation. These studies were made possible through the use of magnetic resonance methods. Prior to the phenotype change from normal vessel development to NV, we found little support for a pathogenic role of focal retinal hypoxia at the border of vascular and avascular retina. However, key links were found between retinal NV and functional panretinal defects in both oxygenation to a provocation and intraretinal ion regulation. Through a treatment which reduced NV incidence but not panretinal pathophysiology, proliferative disease was found to last longer than that in the untreated group. These considerations provide compelling evidence that clinical attention directed toward reducing retinal NV should include approaches that reduce functional panretinal pathophysiology.
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Funding support from National Institutes of Health Grant EY018109 and an unrestricted grant from Research to Prevent Blindness is gratefully acknowledged. We thank Dave Bissig for his careful reading of and thoughtful suggestions to this manuscript.
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Berkowitz, B.A., Roberts, R. Evidence for a critical role of panretinal pathophysiology in experimental ROP. Doc Ophthalmol 120, 13–24 (2010). https://doi.org/10.1007/s10633-009-9175-8
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DOI: https://doi.org/10.1007/s10633-009-9175-8