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Association of Helicobacter pylori with Chronic Kidney Diseases: A Meta-Analysis

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Abstract

Background/Objectives

The reported risk of chronic kidney disease (CKD) in patients with Helicobacter pylori infection is conflicting. This meta-analysis was conducted to summarize all available data and to estimate the prevalence and association between H. pylori and kidney disease and CKD.

Methods

Comprehensive literature review was conducted using MEDLINE and EMBASE database through October 2016 to identify studies that reported the prevalence or the association between H. pylori infection and non-dialysis-dependent kidney diseases or CKD. Effect estimates from the individual study were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird.

Results

Of 4546 studies, nine cross-sectional studies met the eligibility criteria and were included in the meta-analysis. The estimated prevalence of H. pylori infection among subjects with kidney disease was 53% (95% CI 45–61%). The pooled OR of H. pylori in patients with non-dialysis-dependent kidney diseases was 1.20 (95% CI 0.73–1.97) when compared with the patients without kidney diseases. The meta-analysis was then limited to only studies evaluating the risk of H. pylori in CKD; the pooled OR of H. pylori in patients with CKD was 1.00 (95% CI 0.58–1.71).

Conclusions

The estimated prevalence of H. pylori in patients with non-dialysis-dependent kidney diseases is 53%. This study does not support the association between H. pylori infection and non-dialysis-dependent kidney diseases nor CKD.

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Authors’ contributions

All authors had access to the data and a role in writing the manuscript.

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Authors and Affiliations

  1. Department of Internal Medicine, Bassett Medical Center, One Atwell Road, Cooperstown, NY, 13326, USA

    Karn Wijarnpreecha, Charat Thongprayoon & Ridhmi Rajapakse

  2. Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA

    Pitchaphon Nissaisorakarn

  3. Department of Internal Medicine, University of Hawaii, Honolulu, HI, USA

    Veeravich Jaruvongvanich

  4. Cape Fear Center for Digestive Disease, P.A., Fayetteville, NC, USA

    Kiran Nakkala

  5. Division of Nephrology, Department of Medicine, Mayo Clinic, Rochester, MN, USA

    Wisit Cheungpasitporn

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  1. Karn Wijarnpreecha
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  2. Charat Thongprayoon
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  4. Veeravich Jaruvongvanich
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Correspondence to Karn Wijarnpreecha.

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Wijarnpreecha, K., Thongprayoon, C., Nissaisorakarn, P. et al. Association of Helicobacter pylori with Chronic Kidney Diseases: A Meta-Analysis. Dig Dis Sci 62, 2045–2052 (2017). https://doi.org/10.1007/s10620-017-4516-z

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  • DOI: https://doi.org/10.1007/s10620-017-4516-z

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