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Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?

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Abstract

Purpose of Review

This review aims to analyse the consistency of reports suggesting the role of Diabetes Mellitus in the pathogenesis of Helicobacter pylori (H. pylori).

Recent Findings

There have been numerous controversies citing the prevalence of H. pylori infections in patients suffering from type 2 diabetes mellitus (T2DM). This review investigates the possible crosstalk between H. pylori infections and T2DM and also designs a meta-analysis to quantify the association. Subgroup analyses have also been conducted to deduce factors like geography and testing techniques, in playing a role in stratification analysis.

Summary

Based on a scientific literature survey and meta-analysis of databases from 1996 to 2022, a trend towards more frequent H. pylori infections in patients with diabetes mellitus was observed. The highly diversified nature of H. pylori infections across age, gender, and geographical regions requires large interventional studies to evaluate its long-term association with diabetes mellitus. Further possible linkage of the prevalence of diabetes mellitus concomitant with that of H. pylori infected patients has also been delineated in the review.

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Abbreviations

BMI:

Body mass index

CagA:

Cytotoxin-associated gene A

CI:

Confidence interval

DM:

Diabetes mellitus

GI:

Gastrointestinal

H. pylori :

Helicobacter pylori

HbA1c:

Glycated haemoglobin

OR:

Odd ratio

T2DM:

Type 2 diabetes mellitus

VacA:

Vacuolating toxin A

WAT:

White adipose tissue

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Authors and Affiliations

  1. Department of Biotechnology, National Institute of Technology Durgapur, Durgapur, West Bengal, India, 713209

    Om Saswat Sahoo, Rhiti Mitra, Arghyadeep Bhattacharjee & Oindrilla Mukherjee

  2. Department of Microbiology, Kingston College of Science, Beruanpukuria, Barasat, West Bengal, India, 700129

    Arghyadeep Bhattacharjee

  3. Department of Mathematics, National Institute of Technology Durgapur, Durgapur, West Bengal, India, 713209

    Samarjit Kar

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  1. Om Saswat Sahoo
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Contributions

Om Saswat Sahoo: writing — original draft, review and figure preparation. Rhiti Mitra: writing — collection and analysis of data. Arghyadeep Bhattacharjee: writing — review and editing. Samarjit Kar: proofreading the manuscript and reviewing the statistical process. Oindrilla Mukherjee: idea development, manuscript preparation and manuscript revision. All the authors read and approved the final review draft.

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Correspondence to Oindrilla Mukherjee.

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Sahoo, O.S., Mitra, R., Bhattacharjee, A. et al. Is Diabetes Mellitus a Predisposing Factor for Helicobacter pylori Infections?. Curr Diab Rep 23, 195–205 (2023). https://doi.org/10.1007/s11892-023-01511-5

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