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Safety and Efficacy of a Same-Day Low-Volume 1 L PEG Bowel Preparation in Colonoscopy for the Elderly People and People with Renal Dysfunction

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Abstract

Introduction

A same-day low-volume 1 L polyethylene glycol (PEG) for bowel preparation before colonoscopy was developed to improve patients’ compliance. We aimed to evaluate the efficacy and safety of this regimen especially for the elderly and patients with renal dysfunction.

Methods

All consecutive patients who underwent colonoscopy in our center from November 2014 to September 2015 were included. Patients undertook a low-residue diet with 10 mL sodium picosulfate 1 day before colonoscopy. Subsequently, they had 1 L low-volume PEG (MoviPrep) and 0.5 L water 4 h before the examination. Clinical outcomes, including cleansing level using the Boston bowel preparation score (BBPS), in the elderly and special-elderly (65–79 and ≥80 years old) were analyzed and compared with the non-elderly (18–64 years old). Additionally, patients with renal dysfunction were analyzed with respect to both complications and changes in blood parameters.

Results

A total of 5427 patients (mean age: 64.5 ± 13.8) were analyzed. The rate of BBPS ≥ 6 in the elderly (2761 patients), special-elderly (565 patients), and non-elderly (2101 patients) was 94.1, 91.8, and 94.6 %, respectively. In the special-elderly, the rate of renal dysfunction was 14.8 %, and no severe complications were detected after colonoscopy. Additionally, there were no severe complications in 86 patients with renal dysfunction, though elevation of hematocrit was shown after intake of 1 L PEG (before, 36.7 ± 6.1 vs. after, 39.0 ± 5.7, P = 0.006).

Conclusions

Our study shows the safety and efficacy of same-day low-volume 1 L PEG bowel preparation in colonoscopy for the elderly and patients with renal dysfunction.

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Acknowledgments

We thank all members of the Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, for helping with this study.

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Authors and Affiliations

  1. Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Naohisa Yoshida, Yuji Naito, Takaaki Murakami, Ryohei Hirose, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi & Yoshito Itoh

  2. Division of Gastroenterology and Hepatology, University Medicine Cluster, National University Hospital, Singapore, Singapore

    Kewin Tien Ho Siah

  3. Department of Gastroenterology, Murakami Memorial Hospital, Gifu, Japan

    Nobuaki Yagi

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  1. Naohisa Yoshida
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  2. Yuji Naito
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  16. Yoshito Itoh
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Corresponding author

Correspondence to Naohisa Yoshida.

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Conflict of interest

Yoshito Itoh received a research grant from Ajinomoto Pharmaceutical Co., Ltd. Yuji Naito received research grants from Otsuka Pharmaceutical Co., Ltd., and Takeda Pharmaceutical Co., Ltd. The other authors have no conflicts of interest to declare.

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Yoshida, N., Naito, Y., Murakami, T. et al. Safety and Efficacy of a Same-Day Low-Volume 1 L PEG Bowel Preparation in Colonoscopy for the Elderly People and People with Renal Dysfunction. Dig Dis Sci 61, 3229–3235 (2016). https://doi.org/10.1007/s10620-016-4262-7

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  • DOI: https://doi.org/10.1007/s10620-016-4262-7

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