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Effects of Sibutramine on Gastric Emptying, Intestinal Motility and Rectal Tone in Dogs

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Abstract

The aim of this study was to evaluate the effects of sibutramine on gastric emptying, small-bowel contractions, rectal tone and compliance, and gastrointestinal myoelectrical activity. The study was performed in 14 dogs. It was composed of three separate experiments: gastric emptying of liquids and gastrointestinal slow waves; small-bowel contractions; and rectal tone and rectal compliance. Each experiment included two sessions: a control session and a treatment session with sibutramine (5 mg/kg orally) administrated 2 h before the study. Sibutramine significantly accelerated liquid gastric emptying at 75 and 90 min after the meal but did not alter gastrointestinal slow waves. Gastric emptying at 75 and 90 min was 61.42 ± 7.71 and 66.32 ± 7.67% in the control session, and increased to 71.27 ± 5.14 and 75.93 ± 5.29% in the session with sibutramine (p < 0.05, vs. control). Sibutramine significantly inhibited postprandial small-bowel contractions. Sibutramine did not alter the rectal tone, but significantly increased rectal compliance. Sibutramine accelerates gastric emptying of liquids but inhibits small-bowel contractions. These findings suggest the peripheral mechanisms of sibutramine in reducing food intake and causing weight loss in obesity patients.

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Authors and Affiliations

  1. Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA

    Junying Xu & Jiande DZ Chen

  2. Division of Gastroenterology, GI Research, Route 0632, Room 221, Microbiology Building, 1108 The Strand, Galveston, TX, 77555-0632, USA

    Jiande DZ Chen

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  1. Junying Xu
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  2. Jiande DZ Chen
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Correspondence to Jiande DZ Chen.

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Xu, J., DZ Chen, J. Effects of Sibutramine on Gastric Emptying, Intestinal Motility and Rectal Tone in Dogs. Dig Dis Sci 53, 155–162 (2008). https://doi.org/10.1007/s10620-007-9837-x

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  • DOI: https://doi.org/10.1007/s10620-007-9837-x

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