Abstract
Hormone replacement therapy (HRT) containing estrogens is generally used to relieve climacteric symptoms and to prevent osteoporosis and coronary heart disease [1], however, there has been increasing evidence of the HRT as the risk of hormone-dependent neoplasms including breast cancer [2], uterine endometrial cancer [3], ovarian cancer [4], and even lung cancer [5]. Noteworthy is mucinous cyst neoplasms (MCNs) of the pancreas, characterized by mucin-producing columnar epithelium supported by “ovarian-like” mesenchymal stroma, occur mostly in females expressing estrogen receptors [6, 7]. Although several reports regarding the closed relationship between MCNs and pregnancy [8, 9] might imply potential sex hormone-dependency of the MCNs [10], no correlation has been reported. This is the first case report of malignant MCN developing during continuous HRT after hysterectomy.
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Acknowledgements
We thank Dr. Kiyoko Kato for the helpful comments on the HRT.
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Tanaka, S., Kawamura, T., Nakamura, N. et al. Mucinous Cystadenocarcinoma of the Pancreas Developing During Hormone Replacement Therapy. Dig Dis Sci 52, 1326–1328 (2007). https://doi.org/10.1007/s10620-006-9482-9
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DOI: https://doi.org/10.1007/s10620-006-9482-9