Abstract
Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73± 1.1 in the H. pylori-negative group, whereas it was 2.56 ± 1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance.
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References
Cave DR: Transmission and epidemiology of Helicobacter pylori. Am J Med 100:12–17, 1996
Pellicano R, Fagoonee S, Rizzetto M, Ponzetto A: Helicobacter pylori and coronary heart disease: which directions for future studies? Crit Rev Microbiol 29:351–359, 2003
Wyle FA: Helicobacter pylori: current perspectives. J Clin Gastroenterol 13(Suppl 1):S114–S124, 1991
Misiewicz JJ: Current insights in the pathogenesis of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 7:701–703, 1995
Brown LM: Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 22:283–297, 2000
Leontiadis GI, Sharma VK, Howden CW: Non-gastrointestinal tract associations of Helicobacter pylori infection. Arch Intern Med 159:925–940, 1999
Moller DE, Flier JS: Insulin resistance—Mechanisms, syndromes, and implications. N Engl J Med 325:938–948, 1991
Matthaei S, Stumvoll M, Kellerer M, Haring HU: Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev 21:585–618, 2000
Yip J, Facchini FS, Reaven GM: Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. J Clin Endocrinol Metab 83:2773–2776, 1998
Hanley AJ, Williams K, Gonzalez C, D'Agostino RB Jr, Wagenknecht LE, Stern MP, Haffner SM: Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study. Diabetes 52:463–469, 2003
Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM: Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 97:996–1001, 1998
Haffner SM, Miettinen H: Insulin resistance implications for type II diabetes mellitus and coronary heart disease. Am J Med 103:152–162, 1997
Shinohara K, Shoji T, Emoto M, Tahara H, Koyama H, Ishimura E, Miki T, Tabata T, Nishizawa Y: Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 13:1894–1900, 2002
Acbay O, Celik AF, Gundogdu S: Does Helicobacter pylori-induced gastritis enhance food-stimulated insulin release? Dig Dis Sci 41:1327–1331, 1996
Moss SF, Legon S, Bishop AE, Polak JM, Calam J: Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet 340:930–932, 1992
Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care 27:1487–1495, 2004
Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M: Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23:57–63, 2000
Lebovitz HE, Banerji MA: Insulin resistance and its treatment by thiazolidinediones. Recent Prog Horm Res 56:265–294, 2001
Lebovitz HE: Insulin resistance and the insulin resistance syndrome. In Clinician's Manual on Insulin Resistance. London, Science Press, 2002
Weyer C, Tataranni PA, Bogardus C, Pratley RE: Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 24:89–94, 2001
Fernandez-Real JM, Ricart W: Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24:278–301, 2003
Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, Bergman R: Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. Circulation 93:1809–1817, 1996
Svenson KL, Pollare T, Lithell H, Hallgren R: Impaired glucose handling in active rheumatoid arthritis: relationship to peripheral insulin resistance. Metabolism 37:125–130, 1988
Festa A, D'Agostino R, Jr., Howard G, Mykkanen L, Tracy RP, Haffner SM: Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102:42–47, 2000
Candelli M, Rigante D, Marietti G, Nista EC, Crea F, Bartolozzi F, Schiavino A, Pignataro G, Silveri NG, Gasbarrini G, Gasbarrini A: Helicobacter pylori, gastrointestinal symptoms, and metabolic control in young type 1 diabetes mellitus patients. Pediatrics 111:800–803, 2003
Bayraktaroglu T, Aras AS, Aydemir S, Davutoglu C, Ustundag Y, Atmaca H, Borazan A: Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis. Mediators Inflamm 13:25–28, 2004
Kaneko H, Konagaya T, Kusugami K: Helicobacter pylori and gut hormones. J Gastroenterol 37:77–86, 2002
Calam J: Helicobacter pylori modulation of gastric acid. Yale J Biol Med 72:195–202, 1999
Peach HG, Barnett NE: Helicobacter pylori infection and fasting plasma glucose concentration. J Clin Pathol 54:466–469, 2001
Rehfeld JF, Stadil F: The effect of gastrin on basal- and glucose-stimulated insulin secretion in man. J Clin Invest 52:1415–1426, 1973
Colturi TJ, Unger RH, Feldman M: Role of circulating somatostatin in regulation of gastric acid secretion, gastrin release, and islet cell function. Studies in healthy subjects and duodenal ulcer patients. J Clin Invest 74:417–423, 1984
Candelli M, Rigante D, Marietti G, Nista EC, Crea F, Schiavino A, Cammarota G, Pignataro G, Petrucci S, Gasbarrini G, Gasbarrini A: Helicobacter pylori eradication rate and glycemic control in young patients with type 1 diabetes. J Pediatr Gastroenterol Nutr 38:422–425, 2004
McMahon MM, Bistrian BR: Host defenses and susceptibility to infection in patients with diabetes mellitus. Infect Dis Clin North Am 9:1–9, 1995
Gasbarrini A, Ojetti V, Pitocco D, De Luca A, Franceschi F, Candelli M, Sanz TE, Pola P, Ghirlanda G, Gasbarrini G: Helicobacter pylori infection in patients affected by insulin-dependent diabetes mellitus. Eur J Gastroenterol Hepatol 10:469–472, 1998
Oldenburg B, Diepersloot RJ, Hoekstra JB: High seroprevalence of Helicobacter pylori in diabetes mellitus patients. Dig Dis Sci 41:458–461, 1996
de Luis DA, de la CH, Roy G, de Argila CM, Valdezate S, Canton R, Boixeda D: Helicobacter pylori infection and insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 39:143–146, 1998
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Aydemir, S., Bayraktaroglu, T., Sert, M. et al. The Effect of Helicobacter pylori on Insulin Resistance. Dig Dis Sci 50, 2090–2093 (2005). https://doi.org/10.1007/s10620-005-3012-z
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DOI: https://doi.org/10.1007/s10620-005-3012-z