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The Effect of Helicobacter pylori on Insulin Resistance

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Abstract

Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylorihas been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. Sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73± 1.1 in the H. pylori-negative group, whereas it was 2.56 ± 1.54 in the H. pylori-positive group (P < 0.05). This study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance.

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Authors and Affiliations

  1. Departments of Gastroenterology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey

    Selim Aydemir MD & Yucel Ustundag MD

  2. Departments of Endocrinology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey

    Taner Bayraktaroglu MD & Hulusi Atmaca MD

  3. Departments of Internal Medicine, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey

    Mehmet Sert MD, Coskun Sokmen MD & Ali Borazan MD

  4. Departments of Biochemistry, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey

    Gorkem Mungan MD

  5. Departments of Pathology, Zonguldak Karaelmas University, Faculty of Medicine, Zonguldak, Turkey

    Banu Dogan Gun MD

  6. Zonguldak Karaelmas Universitesi Tıp Fakültesi, İç Hastalıkları ABD, Gastroenteroloji BD, 67800, Zonguldak, Turkey

    Selim Aydemir MD

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  1. Selim Aydemir MD
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  2. Taner Bayraktaroglu MD
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  3. Mehmet Sert MD
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  4. Coskun Sokmen MD
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  5. Hulusi Atmaca MD
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  7. Banu Dogan Gun MD
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  9. Yucel Ustundag MD
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Correspondence to Selim Aydemir MD.

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Aydemir, S., Bayraktaroglu, T., Sert, M. et al. The Effect of Helicobacter pylori on Insulin Resistance. Dig Dis Sci 50, 2090–2093 (2005). https://doi.org/10.1007/s10620-005-3012-z

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  • DOI: https://doi.org/10.1007/s10620-005-3012-z

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