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Direct Autoradiographic Evidence that Rebamipide Interacts with Neutrophils in Dextran Sulfate Sodium Induced Colitis in Rats

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Abstract

To determine the effects of rebamipide during the early stages of colitits development, colitis was induced in rats by oral administration of dextran sulfate sodium for 3 or 7 days. The target sites of 3H-rebamipide were examined by intra-aortic infusion of the radiolabeled compound followed by autoradiography. 3H-rebamipide was localized in goblet cells in the colon of the control rat, whereas it accumulated in the cytoplasm of mesenchymal cells in dextran sulfate sodium treated rats, localized predominatly to polymorphonuclear leucocytes.

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References

  1. Copper HS, Murthy SN, Shah RS, Sedergran DJ: Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238–249, 1993

    PubMed  Google Scholar 

  2. Shichijo K, Gotteried M, Sekine I, Pappas TN: Dextran sulfate sodium-induced colitis in immunodeficient rats. Dig Dis Sci 45:2320–2326, 2000

    Article  PubMed  Google Scholar 

  3. Nagata T, Nawa T, Yokota S: A new technique for electron microscopic dry-mounting radioautography of soluble compounds. Histochemie 18:241–249, 1969

    Article  PubMed  Google Scholar 

  4. Nakamura M, Oda M, Yonei Y, Tsukada N, Komatsu H, Kaneko K, Tsuchiya M: Muscarinic acetylcholine receptors in rat gastric mucosa a radioautographic study using a potent muscarinic antagonist, 3H-pirenzepine. Histochemistry 83:479–487, 1985

    Article  PubMed  Google Scholar 

  5. Kishimoto S, Haruma K, Tari A, Sakurai K, Nakano M, Nakagawa Y: Rebamipide, an antiulcer drug, prevents DSS-induced colitis formation in rats. Dig Dis Sci 45:1608–1616, 2000

    Article  PubMed  Google Scholar 

  6. Iwai A, Iwashita E: Changes in colonic inflammation induced by dextran sulfate sodium (DSS) during short- and long-term administration of rebamipide. Dig Dis Sci 43(9):143S–147S, 1998

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Masahiko Nakamura, Koichiro Atsuda & Kanji Tsuchimoto

  2. Graduate School of Pharmaceutical Science, Kitasato University, Japan

    Tetsufumi Takahashi & Haruki Yamada

  3. Kitasato Institute for Life Sciences & Graduate School of Infection Control Science, Kitasato University, Japan

    Tsukasa Matsumoto, Hidenori Matsui & Haruki Yamada

  4. Oriental Medicine Research Center, Kitasato Institute, Kitasato University, Japan

    Tsukasa Matsumoto & Haruki Yamada

  5. Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan

    Norifumi Hibi

Authors
  1. Masahiko Nakamura
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  2. Tetsufumi Takahashi
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  3. Tsukasa Matsumoto
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  4. Koichiro Atsuda
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  5. Norifumi Hibi
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  6. Hidenori Matsui
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  7. Haruki Yamada
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  8. Kanji Tsuchimoto
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Corresponding author

Correspondence to Masahiko Nakamura.

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Nakamura, M., Takahashi, T., Matsumoto, T. et al. Direct Autoradiographic Evidence that Rebamipide Interacts with Neutrophils in Dextran Sulfate Sodium Induced Colitis in Rats. Dig Dis Sci 50 (Suppl 1), S113–S118 (2005). https://doi.org/10.1007/s10620-005-2815-2

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  • DOI: https://doi.org/10.1007/s10620-005-2815-2

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