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Two New Antifungal Indole Alkaloids from an Endophytic Fungi Aspergillus felis Obtained from Cigar Tobacco

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Chemistry of Natural Compounds Aims and scope

With the aim of screening more bioactivity metabolites, in this study, two new indole alkaloids, felisindoles A and B (1 and 2), were isolated from the cigar tobacco-derived endophytic fungi Aspergillus felis. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic data. Interestingly, the anti-fungi activity assay revealed that compounds 1 and 2 showed potential anti-G. cichoracearum (the main pathogen of tobacco powdery mildew disease) activity with inhibition rates of 72.6% ± 5.2, and 61.7% ± 5.0, respectively, compared to the negative control. However, these rates are lower than that of the positive control (with an inhibition rate of 93.2% ± 5.5).

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Acknowledgment

This project was supported by the Foundation of the China Tobacco Monopoly Bureau Grants and Yunnan Provincial Tobacco Monopoly Bureau Grants (2021530000241002), the National Natural Science Foundation of China (No. 32260111), the Foundation of Yunnan Innovative Research Team (2019HC020), and the Foundation for Key Laboratory of Yunnan Provincial Department of Education (2022HD021).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicina Endophytes Resources, Yunnan Minzu University, 650500, Kunming, P. R. China

    Ling-Wang Kong, Wan-Ya Qiu, Meng-Si Chen, Yin-Ke Li & Qiu-Fen Hu

  2. Yunnan Academy of Tobacco Agricultural Sciences, 650021, Kunming, P. R. China

    Wan-Long Yang, Jun-Ru Shen, Xu-Bing Tang, Xiao-Hui He & Guang-Hui Kong

  3. Yunnan Oriental Tobacco Co., Ltd, 678000, Baoshan, P. R. China

    Wan-Long Yang, Jun-Ru Shen, Xu-Bing Tang & Xiao-Hui He

Authors
  1. Ling-Wang Kong
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  2. Wan-Ya Qiu
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  9. Qiu-Fen Hu
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  10. Guang-Hui Kong
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Corresponding authors

Correspondence to Qiu-Fen Hu or Guang-Hui Kong.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 955–958.

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Kong, LW., Qiu, WY., Chen, MS. et al. Two New Antifungal Indole Alkaloids from an Endophytic Fungi Aspergillus felis Obtained from Cigar Tobacco. Chem Nat Compd 59, 1132–1136 (2023). https://doi.org/10.1007/s10600-023-04210-5

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  • DOI: https://doi.org/10.1007/s10600-023-04210-5

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