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Synthesis and Cytotoxic Activity of a New Derivative of Rupestonic Acid

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Chemistry of Natural Compounds Aims and scope

Twenty new amide derivatives of rupestonic acid were synthesized. Their cytotoxic activities against four human cancer cell lines (HeLa, HT-29, A549, and HepG2) were established. Compound 2p was active against A549 (IC50 = 10.31 μM) and HepG2 cell lines (IC50 = 5.44 μM). Derivative 2q showed better cytotoxic activity against HeLa (IC50 = 7.95 μM) and HT-29 cancer cells (IC50 = 2.49 μM).

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Acknowledgment

The work was financially supported by the West Light Foundation, Chinese Academy of Sciences (Grant No. 2020-XBQNXZ-007) and the National Program of Key Research and Development of China (Grant No. 2020YFE0205600).

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Authors and Affiliations

  1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 830011, Urumqi, P. R. China

    P. Aibibula, H. A. Aisa, K. Bozorov & J. Zhao

  2. University of Chinese Academy of Sciences, 100049, Beijing, P. R. China

    P. Aibibula, H. A. Aisa & J. Zhao

  3. Chemistry Faculty, Samarkand State University, 15 Universitetskii Blvd., 140104, Samarkand, Uzbekistan

    K. Bozorov

Authors
  1. P. Aibibula
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  2. H. A. Aisa
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  3. K. Bozorov
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  4. J. Zhao
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Corresponding author

Correspondence to J. Zhao.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 930–935.

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Aibibula, P., Aisa, H.A., Bozorov, K. et al. Synthesis and Cytotoxic Activity of a New Derivative of Rupestonic Acid. Chem Nat Compd 59, 1102–1108 (2023). https://doi.org/10.1007/s10600-023-04205-2

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  • DOI: https://doi.org/10.1007/s10600-023-04205-2

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