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Carboline Alkaloids from the Cigar Tobacco-Derived Fungi Aspergillus sp. and Their Anti-TMV Activity

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Chemistry of Natural Compounds Aims and scope

Two new β-carboline alkaloids, 1-acetyl-6-hydroxymethyl-7-methoxy-β-carboline (1) and 1-acetyl-6- hydroxymethyl-8-methoxy-β-carboline (2), together with four known ones (3–6) were isolated from the cigar tobacco (a variety of Nicotiana tabacum L.)-derived endophytic fungi Aspergillus sp. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The anti-TMV activities test revealed that compounds 1 and 2 showed potential anti-TMV activities with inhibition rates of 31.8 and 35.5%, respectively. These rates are close to that of positive control. Compounds 3–6 also showed anti-TMV activities with inhibition rates in the range of 21.5–28.8%, respectively. The isolation of the aforementioned β-carboline alkaloids may provide materials for the screening of anti-TMV activity inhibitors and contribute to the utilization of cigar tobacco-derived endophytic fungi.

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Acknowledgment

This project was supported by the Foundation of the China Tobacco Monopoly Bureau Grants and Yunnan Provincial Tobacco Monopoly Bureau Grants (110202103018, 2022530000241002), the National Natural Science Foundation of China (No. 32260111), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicina Endophytes, Yunnan Minzu University, 650500, Kunming, P. R. China

    Xue-Ju Cha, Gui Pu, Rui-Feng Xiong, Yue-Yu Ma, Qiu-Fen Hu & Yin-Ke Li

  2. Yunnan Academy of Tobacco Agricultural Sciences, 650021, Kunming, P. R. China

    Gui Pu, Guang-Hai Zhang, Heng Yao, Guang-Hui Kong & Yu-Ping Wu

  3. Kunming Institute of Botany, Chinese Academy of Sciences, 650201, Kunming, P. R. China

    Mei-Fen Bao

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  1. Xue-Ju Cha
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Correspondence to Yin-Ke Li or Yu-Ping Wu.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2023, pp. 743–746.

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Cha, XJ., Pu, G., Xiong, RF. et al. Carboline Alkaloids from the Cigar Tobacco-Derived Fungi Aspergillus sp. and Their Anti-TMV Activity. Chem Nat Compd 59, 881–885 (2023). https://doi.org/10.1007/s10600-023-04140-2

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  • DOI: https://doi.org/10.1007/s10600-023-04140-2

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