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Bioactive Indole Alkaloids from the Tobacco-Derived Endophytic Fungus Aspergillus fumigatus

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Chemistry of Natural Compounds Aims and scope

Two new indole alkaloids, 1-(5-prenyl-1H-indol-3-yl)propan-2-one (1) and 1-(6-methoxy-5-prenyl-1H-indol-3-yl)propan-2-one (2), along with five known ones (3–7) were isolated from the fermentation products of a cigar tobacco-derived endophytic fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV). The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 26.5 and 28.8%, respectively.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (Nos. 81860624 and 21967021), the Foundation of chemical and Biological Innovation Studio of Yunnan Industrial Co., Ltd., the Foundation of Yunnan Applied Basic Research for Excellent Young Scholars (No. 202001AW079992), and the Foundation of Yunnan Innovative Research Team (No. 2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal, State Ethnic Affairs Commission, Yunnan Minzu University, 650031, Kunming, P. R. China

    Yue-Yu Ma, Si-Yu Shen, Shan-Shan Li, Xiao-Shan Liu, Yin-Ke Li, Dong Miao, Min Zhou, Wei-Guang Wang, Gang Du & Qiu-fen Hu

  2. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Yue-Yu Ma, Wen Xiong, Yin-Ke Li & Xiao-Wei Ma

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  1. Yue-Yu Ma
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Correspondence to Qiu-fen Hu or Xiao-Wei Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 444–447.

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Ma, YY., Xiong, W., Shen, SY. et al. Bioactive Indole Alkaloids from the Tobacco-Derived Endophytic Fungus Aspergillus fumigatus. Chem Nat Compd 59, 524–528 (2023). https://doi.org/10.1007/s10600-023-04041-4

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  • DOI: https://doi.org/10.1007/s10600-023-04041-4

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