Extraction and chromatographic separation of the extracts of dried leaves of Glycosmis lucida lead to the isolation of a new acridone alkaloid lucidaine A (1), along with two known analogues 2 and 3. The structure of 1 was established by extensive spectroscopic analysis (1D and 2D NMR, HR-ESI-MS), and the known compounds were identified by comparisons with data reported in the literature. Furthermore, the cytotoxicity activities of all isolated alkaloids in vitro were evaluated.
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Acknowledgment
This research was financially supported by the Young Innovative Talents Project of General Colleges and Universities in Guangdong Province (No. 2021KQNCX049), the Special program for Natural Science Talents of Lingnan Normal University (Nos. ZL1903 and ZL1403), the Open Project of Western Guangdong Characteristic Biology and Medicine Engineering and Research Center (No. 2022-K04), and the public service platform of biomedical resources research and development of South China sea (No. 2017C8B2).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2023, pp. 736–738.
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Wu, SY., Chen, ZM., Zhou, ZL. et al. A New Acridone Alkaloid from the Leaves of Glycosmis lucida. Chem Nat Compd 59, 872–875 (2023). https://doi.org/10.1007/s10600-023-04138-w
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DOI: https://doi.org/10.1007/s10600-023-04138-w