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Two New Sesquiterpenes from Leaves of Nicotiana tabacum and their Antibacterial Activity

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Chemistry of Natural Compounds Aims and scope

Two new sesquiterpenes, nicosesquites A and B (1 and 2) as well as four known sesquiterpenes (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their antimethicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 13.4 ± 2.2, and 14.6 ± 2.4 mm, respectively. In addition, compounds 1 and 2 also have weak floral fragrances, and they have the potential value for use as an essence for cigarettes.

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Acknowledgment

This project was supported financially by the Foundation of Yunnan Tobacco Company (No. 2021530000241009), the Foundation Yunnan Tobacco Industry Co. Ltd. (No. JB2022XY03), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Jie-Yun Cai, Jia-Meng Dai, Wen Xiong, Wei Zhao, Yong Li, Hao-Cheng Cai, Qiu-Fen Hu, Wei-Guang Wang & Shan-Zhai Shang

  2. Yunnan Tobacco Quality Supervision and Test Station, Kunming, 650106, Yunnan, P. R. China

    Jie-Yun Cai, Hui-Ping Wang & Shi-Chun Qin

  3. Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, 650031, Kunming, P. R. China

    Qiu-Fen Hu & Wei-Guang Wang

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  1. Jie-Yun Cai
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Correspondence to Shan-Zhai Shang.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 421–424.

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Cai, JY., Dai, JM., Xiong, W. et al. Two New Sesquiterpenes from Leaves of Nicotiana tabacum and their Antibacterial Activity. Chem Nat Compd 59, 497–501 (2023). https://doi.org/10.1007/s10600-023-04034-3

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  • DOI: https://doi.org/10.1007/s10600-023-04034-3

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