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Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity

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Chemistry of Natural Compounds Aims and scope

Two new chromones, 8-(3-hydroxypropyl)-2-(3-hydroxy-1-oxopropyl)-6-methoxy-4H-chromen-4-one (1), 2-acetyl-8-(3-hydroxypropyl)-6-methoxy-4H-chromen-4-one (2), along with four known ones (3–6) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor derived from tobacco. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited potential anti-TMV activities with inhibition rates of 35.3 and 30.6%, respectively, rates that are close to that of positive control.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (Nos. 81860624, 21967021), the Foundation of Yunnan Tobacco Industry Co. Ltd. (No. 2022JY02), and the Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal, State Ethnic Affairs Commission, Yunnan Minzu University, 650031, Kunming, P. R. China

    Si-Yu Shen, Shan-Shan Li, Xiao-Shan Liu, Yin-Ke Li, Dong Miao, Wei-Guang Wang, Gang Du & Qiu-fen Hu

  2. Tobacco Research Institute, Chinese Academy of Agricultural Sciences, 266101, Qingdao, P. R. China

    Si-Yu Shen, Shan-Shan Li, Xiao-Shan Liu & Da-Ping Gong

  3. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd, 650231, Kunming, P. R. China

    Wen Xiong, Yin-Ke Li, Xue-Mei Li & Xiao-Wei Ma

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  1. Si-Yu Shen
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Correspondence to Qiu-fen Hu or Xiao-Wei Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 392–395.

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Shen, SY., Xiong, W., Li, SS. et al. Chromones from the Tobacco Derived Fungus Aspergillus versicolor and Their Antiviral Activity. Chem Nat Compd 59, 462–466 (2023). https://doi.org/10.1007/s10600-023-04024-5

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  • DOI: https://doi.org/10.1007/s10600-023-04024-5

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