Two new coumarin derivatives, 4-(3,5-dihydroxyphenyl)-3,5,7-trihydroxy-2H-chromen-2-one (1) and 4-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(((2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chromen-2-one (2), along with five known compounds, were isolated for the first time from ethyl acetate fraction of Sterculia colorata. Structures of isolated compounds were characterized using spectroscopic techniques, such as EI-MS, 1H NMR, and 13C NMR. Compounds 1 and 2 showed significant immunomodulatory (IC50 = 11.42 ± 0.62 μg/mL and 10.98 ± 0.24 μg/mL) and anticancer activities (IC50 = 2.85 ± 0.18 μg/mL and 2.62 ± 0.15 μg/mL), respectively.
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Acknowledgment
We express our gratitude to the Department of Pharmacy, University of Peshawar, Pakistan for providing the research facility. Further, we would also like to extend our gratitude to the HEJ Research Institute of Chemistry, the International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 371–374.
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Rabbi, F., Nisar, A. Two New Coumarins with Immunomodulatory and Anticancer Activities from Sterculia colorata. Chem Nat Compd 59, 436–440 (2023). https://doi.org/10.1007/s10600-023-04018-3
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DOI: https://doi.org/10.1007/s10600-023-04018-3