Two new anthraquinones, (11S)-1,4,6-trihydroxy-7-(1-hydroxyethyl)-3-methoxyanthracene-9,10-dione (1) and (11S)-1,6-dihydroxy-7-(1-hydroxyethyl)-3-methoxyanthracene-9,10-dione (2), together with six known compounds, including four naphthoquinones (3–6), one thiophene derivative (7), and one cyclohexanedione derivative (8), were isolated from the mangrove rhizosphere soil-derived fungus Fusarium sp. J3-2. Compound 1 displayed weak to moderate antibacterial activities against five strains of pathogenic bacteria with MIC values ranging from 25 to 50 μg/mL. Compound 3 showed weak cytotoxic activities toward human hepatocellular carcinoma cell lines, SMMC-7721 and SGC-7901, with IC50 values of 48.87 and 41.23 μg/mL, respectively. Compounds 1–7 exhibited antifouling activities against the larval settlement of the barnacle Balanus amphitrite.
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The National Natural Science Foundation of China (Nos. 81703411, 42177459, and 41776156) supported this work.
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 202–205.
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Chen, M., Wu, JT., Hao, BC. et al. Two New Anthraquinones from the Marine-Derived Fungus Fusarium sp. J3-2. Chem Nat Compd 59, 237–241 (2023). https://doi.org/10.1007/s10600-023-03965-1
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DOI: https://doi.org/10.1007/s10600-023-03965-1