One new anthraquinone derivative, named 8-O-methylnidurufin (1), together with five known analogues (2–6), have been isolated from a gorgonian-derived fungus, Aspergillus sp. The structures were elucidated by combined spectroscopic methods including 1D and 2D NMR spectral data. All isolated metabolites were evaluated for their cytotoxic and antibacterial activities in vitro. Compound 2 showed significant cytotoxic activity against K562 and HL-60 cell lines with IC50 values of 0.87 and 1.46 μM, respectively.
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Acknowledgment
This work was supported by the Key Program of National Natural Science Foundation of China (No. 41130858), the National Natural Science Foundation of China (Nos. 81172977; 41176121), the Program for New Century Excellent Talents in University, Ministry of Education of China (No. NCET-11-0472), and the Natural Science Foundation of Shandong Province (ZR2011DQ019; ZR2011HM085).
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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2014, pp. 537–539.
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Chen, M., Shao, CL., Kong, CJ. et al. A New Anthraquinone Derivative from a Gorgonian-Derived Fungus Aspergillus sp.. Chem Nat Compd 50, 617–620 (2014). https://doi.org/10.1007/s10600-014-1037-2
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DOI: https://doi.org/10.1007/s10600-014-1037-2