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Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata

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Chemistry of Natural Compounds Aims and scope

Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga pustulata. The structures of the new compounds 1 and 2 were established by detailed spectroscopic data analysis and ECD computational methods. The inhibitory effects of compounds 1–6 against NLRP3 inflammasome activation as well as the cytotoxic activities of compounds 1–4 against MCF-7 and HCT-116 cancer cell lines were investigated. Compound 3 showed weak cytotoxicity against HCT-116 (IC50 = 55.747 ± 3.212 μM).

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (81860615, 82260682, 21762048, 81903541, and 22167021), Applied Basic Research Foundation of Yunnan Province (2018FY001, 2018FA048, 202101AS070022, and 202101AT070195), the Program for Changjiang Scholars and Innovative Research Team in University (IRT_17R94), Project of Innovative Research Team of Yunnan Province (202005AE160005), and Yun Ling Scholar Project to Wei-Lie Xiao, National Key R&D Program of China (2019YFE0109200), and a grant (No. 2021FK004) from YNCUB. Authors thank the Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.

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Authors and Affiliations

  1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research & Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China

    Joseph Sakah Kaunda, Yao-Jun Xu, Chen-Fang Yue, Xing-Jie Zhang, Bin Cheng, Muhammad Amin, Xiao-Li Li & Wei-Lie Xiao

  2. School of Medicine, Yunnan University, 650091, Kunming, P. R. China

    Yuan-Si Chen & Hong-Liang Li

  3. State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, 650091, Kunming, P. R. China

    Wei-Lie Xiao

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  1. Joseph Sakah Kaunda
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  2. Yuan-Si Chen
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  9. Xiao-Li Li
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Correspondence to Hong-Liang Li, Xiao-Li Li or Wei-Lie Xiao.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023, pp. 42–46.

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Kaunda, J.S., Chen, YS., Xu, YJ. et al. Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata. Chem Nat Compd 59, 46–51 (2023). https://doi.org/10.1007/s10600-023-03914-y

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  • DOI: https://doi.org/10.1007/s10600-023-03914-y

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